Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Sandra A Rempel"'
Autor:
Hae Kyung Lee, Ariel Bier, Simona Cazacu, Susan Finniss, Cunli Xiang, Hodaya Twito, Laila M Poisson, Tom Mikkelsen, Shimon Slavin, Elad Jacoby, Michal Yalon, Amos Toren, Sandra A Rempel, Chaya Brodie
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54652 (2013)
Glioblastomas (GBM), the most common and aggressive type of malignant glioma, are characterized by increased invasion into the surrounding brain tissues. Despite intensive therapeutic strategies, the median survival of GBM patients has remained disma
Externí odkaz:
https://doaj.org/article/5b4578dbd2514421a2e85381362b4f5c
Autor:
Kevin R. Bobbitt, Cunli Xiang, Hae Kyung Lee, Simona Cazacu, Susan Finniss, Sandra A. Rempel, Laura Hasselbach, Shimon Slavin, Efrat Bucris, Amotz Ziv-Av, Tom Mikkelsen, Chaya Brodie
Publikováno v:
Oncotarget
// Hae Kyung Lee 1 , Susan Finniss 1 , Simona Cazacu 1 , Efrat Bucris 2 , Amotz Ziv-Av 2 , Cunli Xiang 1 , Kevin Bobbitt 3 , Sandra A. Rempel 4 , Laura Hasselbach 5 , Tom Mikkelsen 5 Shimon Slavin 6 and Chaya Brodie 1,2 1 Davidson Laboratory of Cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fa64bd725639fd9042bad7e984103c
http://europepmc.org/articles/PMC3712579
http://europepmc.org/articles/PMC3712579
Autor:
Jorge A. Gutiérrez, Stacey L. Thomas, Laila M. Poisson, Ezekiell Mouzon, Sandra A. Rempel, Reima El Naili, Archanna Radakrishnan, Nancy Lemke, Sandra Cottingham, Chad R. Schultz, William A. Golembieski
Publikováno v:
Brain Pathology (Zurich, Switzerland)
BACKGROUND: Both enhanced SPARC expression and the loss of p53 tumor suppressor gene are changes that occur early in glioma development. Both SPARC and p53 regulate glioma cell survival by inverse effects on apoptotic signaling. Therefore, during gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e46f120132b28dff5234828a5b7617
https://doi.org/10.1111/bpa.12161
https://doi.org/10.1111/bpa.12161
Autor:
Rachid Drissi, Charles B. Stevenson, Kathleen Dorris, Christopher R. Pierson, Stewart Goldman, Maryam Fouladi, Sandra A. Rempel, Sharon Gardner, Eshini Panditharatna, Mariko DeWire, Matthew Sobo, Randal Olshefski, Arzu Onar-Thomas, Lili Miles
Publikováno v:
Journal of Neuro-Oncology. 117:67-76
Children with high-grade glioma, including diffuse intrinsic pontine glioma (DIPG), have a poor prognosis despite multimodal therapy. Identifying novel therapeutic targets is critical to improve their outcome. We evaluated prognostic roles of telomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599472acac72e9dbcb94412cb75ff29a
https://doi.org/10.1007/s11060-014-1374-9
https://doi.org/10.1007/s11060-014-1374-9
Publikováno v:
Neuro-Oncology. 15:451-461
Background. Secreted protein acidic and rich in cysteine (SPARC) is overexpressed in astrocytomas (World Health Organization grades II–IV). We previously demonstrated that SPARC promotes glioma migration and invasion—in part, by activating the P3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53cf578bd212af42f4fab050de71ba9
https://doi.org/10.1093/neuonc/nos326
https://doi.org/10.1093/neuonc/nos326
Autor:
Michelle Jankowski, Heather M. McClung, Lonni Schultz, Chad R. Schultz, Sandra A. Rempel, William A. Golembieski
Publikováno v:
Carcinogenesis. 33:275-284
We previously demonstrated that secreted protein acidic and rich in cysteine (SPARC) increases heat shock protein 27 (HSP27) expression and phosphorylation and promotes glioma cell migration through the p38 mitogen-activated protein kinase (MAPK)/HSP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6253fc38fa5f0d937f325951c5853c7a
https://doi.org/10.1093/carcin/bgr276
https://doi.org/10.1093/carcin/bgr276
Autor:
E. Helene Sage, Sandra A. Rempel, Gail Workman, Matthew S. Weaver, Chad R. Schultz, Nancy Lemke
Publikováno v:
Journal of Cellular Biochemistry. 112:3093-3102
The matricellular SPARC-family member hevin (Sparc-like 1/SPARCL-1/SC1/Mast9) contributes to neural development and alters tumor progression in a range of mammalian models. Based on sequence similarity, we hypothesized that proteolytic digestion of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363992dcc86c2762f63bd2655d5544a1
https://doi.org/10.1002/jcb.23235
https://doi.org/10.1002/jcb.23235
Autor:
Cunli Xiang, Sandra A. Rempel, Tom Mikkelsen, Stephanie L. Lomonaco, Wei Jiang, Chaya Brodie, Nancy Lemke, Susan Finniss, Hae Kyung Lee
Publikováno v:
Neuro-Oncology. 13:857-865
We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239bf6c9d782447d0f897de81557df11
https://doi.org/10.1093/neuonc/nor073
https://doi.org/10.1093/neuonc/nor073
Autor:
Sandra A. Rempel, Susan Finniss, Tom Mikkelsen, Nancy Lemke, Norman L. Lehman, Cunli Xiang, Simona Cazacu, Chaya Brodie, Hae Kyung Lee, Gila Kazimirsky
Publikováno v:
Neuro-Oncology. 10:236-243
We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patient survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62f42e238fb6210596ef9e94b561789
https://doi.org/10.1215/15228517-2008-006
https://doi.org/10.1215/15228517-2008-006
Autor:
Thomas H. Barker, Chaya Brodie, Stacey L. Thomas, E. Helene Sage, Heather M. McClung, Simona Cazacu, Sandra A. Rempel, Chad R. Schultz, William A. Golembieski, Nancy Lemke, Christopher K. Yunker
Publikováno v:
Glia. 56:1061-1075
Secreted protein acidic and rich in cysteine (SPARC) regulates cell-extracellular matrix interactions that influence cell adhesion and migration. We have demonstrated that SPARC is highly expressed in human gliomas, and it promotes brain tumor invasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c785cd3e3903a24b3d01c12bfff0ca1d
https://doi.org/10.1002/glia.20679
https://doi.org/10.1002/glia.20679