Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sandra M. Lechner"'
Autor:
Marion Lanier, Xiaohu Zhang, John E. Tellew, Zhiyong Luo, Mark Santos, Raymond S. Gross, Deborah H. Slee, Emily Lin, Sandra M. Lechner, Jaimie K. Rueter, María I. Crespo, Jose-Luis Diaz, Yongsheng Chen, Siobhan Malany, Manisha Moorjani, John Saunders, John P. Williams, Binh G. Vong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5402-5405
In this report, the strategy and outcome of expanding SAR exploration to improve solubility and metabolic stability are discussed. Compound 35 exhibited excellent potency, selectivity over A(1) and improved solubility of >4 mg/mL at pH 8.0. In additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799d40e0876b3b15e810f1648d5b9dc2
https://doi.org/10.1016/j.bmcl.2008.09.048
https://doi.org/10.1016/j.bmcl.2008.09.048
Publikováno v:
Neuropsychopharmacology. 34:106-125
Beginning with the discovery of the structure of deoxyribose nucleic acid in 1953, by James Watson and Francis Crick, the sequencing of the entire human genome some 50 years later, has begun to quantify the classes and types of proteins that may have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ea08dfedddb19a8b42c3d17dcbde5
https://doi.org/10.1038/npp.2008.149
https://doi.org/10.1038/npp.2008.149
Autor:
Sandra M. Lechner, Guibao Gu, Linda J. Bristow, Daniel S. Lorrain, Hongbing Wei, Rebecca L. Cole, Lorrie P. Daggett, Xin Zhang, Hervé Schaffhauser
Publikováno v:
Brain Research. 1197:47-62
The receptor localization of metabotropic glutamate receptors (mGlu) 2 and 3 was examined by using in situ hybridization and a well-characterized mGlu2-selective antibody in the rat forebrain. mGlu2 was highly and discretely expressed in cell bodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43079210d858604ef404f6bb3c304e51
https://doi.org/10.1016/j.brainres.2007.12.057
https://doi.org/10.1016/j.brainres.2007.12.057
Autor:
Yongsheng Chen, Mark Santos, Emily Lin, Stacy Markison, John E. Tellew, Sandra M. Lechner, Maria Prat, Xiaohu Zhang, John Saunders, Silvia Gual, Marion Lanier, Marı´a I. Crespo, John P. Williams, Raymond S. Gross, Tanya Joswig, Jaimie K. Rueter, Deborah H. Slee, Siobhan Malany, Jose-Luis Diaz, Manisha Moorjani, Julio C. Castro-Palomino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1778-1783
A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A(2A) antagonists is described. SAR studies led to compound 14 with excellent potency (K(i) = 0.4 nM), selectivity (A(1)/A(2A) > 100), and efficacy (MED 10 mg/kg p.o.) in the rat haloperidol-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dca2261358c58ec30c26ccccacb9f1
https://doi.org/10.1016/j.bmcl.2008.02.032
https://doi.org/10.1016/j.bmcl.2008.02.032
Autor:
Peter Hevezi, Sandra M. Lechner, Anil Pahuja, A. Chen, Richard B. Roth, David G. Alleva, Albert Zlotnik, Gail M. Verge, Richard A. Maki
Publikováno v:
Scandinavian Journal of Immunology. 64:361-369
CC chemokine receptor 7 (CCR7) is involved in the initiation of immune responses by mediating the migration of naive T cells and mature dendritic cells to T-cell-rich zones of secondary lymphoid organs where antigen presen- tation occurs. To address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985ce78686f53426cf8cd067b4b558f1
https://doi.org/10.1111/j.1365-3083.2006.01787.x
https://doi.org/10.1111/j.1365-3083.2006.01787.x
Autor:
Jerry Lee, Gail M. Verge, Peter Hevezi, Albert Zlotnik, Sandra M. Lechner, Genaro Patino-Lopez, Vianney Ortiz-Navarrete, Dorian Willhite
Publikováno v:
Journal of Neuroimmunology. 171:145-155
We have previously reported the characterization of a novel immunoglobulin supergene family member, designated class-I MHC-restricted T cell associated molecule (CRTAM). Here we further characterize human CRTAM and find that it is highly expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb447ae8f3ca7f24622e095e434ef2fa
https://doi.org/10.1016/j.jneuroim.2005.09.017
https://doi.org/10.1016/j.jneuroim.2005.09.017
Publikováno v:
Brain Research. 756:114-124
The present study was designed to elucidate the neurotransmitters involved in activation of the noradrenergic nucleus, locus coeruleus, by distention of the distal colon. Locus coeruleus spontaneous discharge rate was recorded from halothane-anesthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744e59067704b4f800f65f2eb0f1b3a5
https://doi.org/10.1016/s0006-8993(97)00116-9
https://doi.org/10.1016/s0006-8993(97)00116-9
Autor:
Raymond S. Gross, John P. Williams, Tanya Joswig, Emily Lin, Stacy Markison, Deborah H. Slee, Marion Lanier, William Kargo, Jaime Piercey, Jose-Luis Diaz, Zhiyong Luo, John E. Tellew, Zhihong O’Brien, Marilyn Zhao, Siobhan Malany, Kayvon Jalali, Mark Santos, Sandra M. Lechner, Ajay Madan, Xiaohu Zhang, Jenny Wen, Yongsheng Chen, Manisha Moorjani, Robert E. Petroski, María I. Crespo, John Saunders
Publikováno v:
Journal of medicinal chemistry. 52(3)
In the present article, we report on a strategy to improve the physical properties of a series of small molecule human adenosine 2A (hA2A) antagonists. One of the aromatic rings typical of this series of antagonists is replaced with a series of aliph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae503fc7029e4651564ca3936c005ae
https://pubmed.ncbi.nlm.nih.gov/19140664
https://pubmed.ncbi.nlm.nih.gov/19140664
Autor:
Stacy Markison, Sandra M. Lechner, John Saunders, John P. Williams, Silvia Gual, Siobhan Malany, Jaimie K. Rueter, Maria Prat, Raymond S. Gross, Julio C. Castro-Palomino, Tanya Joswig, Kayvon Jalali, Zhiyang Zuo, Manisha Moorjani, Deborah H. Slee, Jose-Luis Diaz, Robert E. Petroski, María I. Crespo, Chun Yang, Yang Sai, Emily Lin, Zhihong O’Brien, Marion Lanier, Xiaohu Zhang, Jenny Wen, Mark Santos, Yongsheng Chen
Publikováno v:
Journal of medicinal chemistry. 51(6)
Previously we have described a series of novel A 2A receptor antagonists with excellent water solubility. As described in the accompanying paper, the antagonists were first optimized to remove an unsubstituted furyl moiety, with the aim of avoiding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226a608572d86ea3081c27e5732dbbd6
https://pubmed.ncbi.nlm.nih.gov/18307293
https://pubmed.ncbi.nlm.nih.gov/18307293
Autor:
Silvia Gual, Chun Yang, Yang Sai, Kayvon Jalali, Sandra M. Lechner, Marion Lanier, Mark Santos, Yongsheng Chen, Maria Prat, Julio C. Castro-Palomino, John Saunders, Stacy Markison, John P. Williams, Emily Lin, Jaimie K. Rueter, Jose-Luis Diaz, María I. Crespo, Zhiyang Zuo, Manisha Moorjani, Deborah H. Slee, Raymond S. Gross, Xiaohu Zhang, Siobhan Malany
Publikováno v:
Journal of medicinal chemistry. 51(6)
Previously we have described a novel series of potent and selective A2A receptor antagonists (e.g., 1) with excellent aqueous solubility.(1) While these compounds are efficacious A2A antagonists in vivo, the presence of an unsubstituted furyl moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635873e0540ea30701b581ce36af9624
https://pubmed.ncbi.nlm.nih.gov/18307292
https://pubmed.ncbi.nlm.nih.gov/18307292