Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sandra, van Dyk"'
Publikováno v:
Planta Medica. 85:1136-1142
Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and neurodegenerative disorders. This study examined the MAO inhibition potential of kavain and other ka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126219c7fd6ae779d802307de4ae0be2
https://doi.org/10.1055/a-1008-9491
https://doi.org/10.1055/a-1008-9491
Autor:
Werner J. Geldenhuys, Jacques Joubert, Yolande Greyling, Sarel F. Malan, Sandra van Dyk, Natasha Strydom
Introduction: Recent research points to the Sigma Receptor (σR) as a possible neuromodulatory system with multi-functional action and σ1Rs have been suggested as a drug target for a number of CNS conditions. Hexacyclododecylamines have shown σ1R a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2312ded65a47c9345f1c6f367e04f49e
https://hdl.handle.net/10394/32404
https://hdl.handle.net/10394/32404
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:809-818
Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodegeneration may therefore be curbed by exogenous hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2901c53a15721c63ebadb30b845d4b6f
https://doi.org/10.1016/j.bmc.2011.11.068
https://doi.org/10.1016/j.bmc.2011.11.068
Autor:
Douglas W. Oliver, Sarel F. Malan, Armand de Vries, Sandra van Dyk, Louis H.A. Prins, Mino R. Caira
Publikováno v:
Journal of Chemical Crystallography. 38:705-709
Polycyclic hydrocarbon compounds exhibit a wide variety of biological activities, ranging from antiviral to Parkinson’s disease. Several structures such as the adamantanes have reached clinical status and are used therapeutically to treat, amongst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc8890415e21cc10edeee83bf679b81
https://doi.org/10.1007/s10870-008-9381-3
https://doi.org/10.1007/s10870-008-9381-3
The design, development and use of small molecule fluorescent ligands to directly or indirectly study receptors, enzymes and other targets in the central nervous system (CNS) have in the recent years become an intense area of investigation, especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f29a45eac46d8fb67f0f221dfaee60
http://www.eurekaselect.com/108105
http://www.eurekaselect.com/108105
Autor:
Francois H. van der Westhuizen, Hendrik J. R. Lemmer, Sandra van Dyk, Jacques Joubert, Sarel F. Malan
A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel and N-methyl-D-aspartate receptor modulating activity. The synthesised compounds were classified into two groups, bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cec52464c9ec3fb6999ce136728c0e
http://www.eurekaselect.com/98946/article
http://www.eurekaselect.com/98946/article
Autor:
Hendrik J R, Lemmer, Jacques, Joubert, Sandra, van Dyk, Francois H, van der Westhuizen, Sarel F, Malan
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 8(3)
A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel and N-methyl-D-aspartate receptor modulating activity. The synthesised compounds were classified into two groups, bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba9f7e332ad1748bcf595889f0d867c2
https://pubmed.ncbi.nlm.nih.gov/22530904
https://pubmed.ncbi.nlm.nih.gov/22530904
Publikováno v:
African Journal of Biotechnology; Vol 10, No 74 (2011); 16976-16985
A large number of diseases such as cancer, cardiovascular disease, inflammatory disease, neurodegenerative disorders and ageing are consequences of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Deoxyribonucleic acid (DNA) damage,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64ef31fe39d714a51e8d0d8770e3985
https://hdl.handle.net/10394/7132
https://hdl.handle.net/10394/7132
A series of fluorescent heterocyclic adamantane amines were synthesised with the goal to develop novel fluorescent ligands for neurological assay development. These derivatives demonstrated multifunctional neuroprotective activity through inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1543f280cbfbf038f82e154c89a1aa15
https://hdl.handle.net/10394/7383
https://hdl.handle.net/10394/7383
A series of polycyclic fluorescent ligands were synthesised and evaluated in murine striatal synaptoneurosomes for N-methyl-D-aspartate receptor (NMDAR) mediated calcium flux inhibition and inhibition of calcium influx through voltage gated calcium c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950cfcfa296592a8c4c8dbf2e1cd21f6
https://hdl.handle.net/10394/7438
https://hdl.handle.net/10394/7438