Aktivität von Lipasen und Esterasen gegenüber tertiären Alkoholen: neue Einblicke in Struktur-Funktions-Beziehungen Wir danken Prof. R. D. Schmid (Institut für Technische Biochemie (ITB), Universität Stuttgart) für hilfreiche Diskussionen und Sandra Vorlová (ITB) für die Bereitstellung rekombinanter hAChE and bAChE. Diese Arbeit wurde von der Deutschen Forschungsgemeinschaft finanziell unterstützt (Bo 1475/2-1).

Autor: Henke, Erik, Pleiss, Jürgen, Bornscheuer, Uwe T.

Publikováno v: Angewandte Chemie; September 2, 2002, Vol. 114 Issue: 17 p3338-3341, 4p

Activity of Lipases and Esterases towards Tertiary Alcohols: Insights into Structure–Function Relationships We thank Prof. R. D. Schmid (Institute of Technical Biochemistry (ITB), Stuttgart University) for helpful discussions and Sandra Vorlová (ITB) for providing recombinant hAChE and bAChE. This work was financed by the German Research Foundation (DFG, Bonn (Germany), Grant Bo 1475/2-1).

Autor: Henke, Erik, Pleiss, Jürgen, Bornscheuer, Uwe T.

Publikováno v: Angewandte Chemie. International Edition; September 2, 2002, Vol. 41 Issue: 17 p3211-3213, 3p

LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy

Autor: Sandra Vorlová, Simona Veitl, Anja E Kuhn, Ster Irmak, Berin Upcin, Sabine Herterich, Matthias Kallius, Leonie Rossow, Daniela Scheld, Jacqueline K. Wax, Franziska Karl, Verena Maltzahn, Erik Henke, H. Hoffmann, Sabine Gätzner, Süleyman Ergün, Rajender Nandigama, Alma Zernecke

Publikováno v: Oncogene

The potential of altering the tumor ECM to improve drug response remains fairly unexplored. To identify targets for modification of the ECM aiming to improve drug response and overcome resistance, we analyzed expression data sets from pre-treatment p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbc94ce71329763c420d3928b126f25
https://doi.org/10.1038/s41388-018-0320-2

Induction of Antagonistic Soluble Decoy Receptor Tyrosine Kinases by Intronic PolyA Activation

Autor: Gina Rocco, Sandra Vorlová, Ken C. Hess, Erik Henke, Michelle L. Hastings, Francine M. Jodelka, Luca Cartegni, Clare V. Lefave

Publikováno v: Molecular Cell. 43(6):927-939

Alternative intronic polyadenylation (IPA) can generate truncated protein isoforms with significantly altered functions. Here, we describe 31 dominant-negative, secreted variant isoforms of receptor tyrosine kinases (RTKs) that are produced by activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edb57670cfdc3761746b09f422b1d1d

VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors

Autor: Andreas Rosenwald, Sandra Vorlová, Florian Röhrig, Erik Henke, David A. Scheinberg, H. Hoffmann, Sabine Gätzner, Isabel Weigand, Zvi Granot, Martin Wartenberg, Olaf Penack, Freddy E. Escorcia, Süleyman Ergün, S Keller, M Tenspolde, Katia Manova

Publikováno v: Oncogene
Röhrig, F; Vorlová, S; Hoffmann, H; Wartenberg, Martin; Escorcia, F E; Keller, S; Tenspolde, M; Weigand, I; Gätzner, S; Manova, K; Penack, O; Scheinberg, D A; Rosenwald, A; Ergün, S; Granot, Z; Henke, E (2016). VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors. Oncogene, 36(1), pp. 1-12. Nature Publishing Group 10.1038/onc.2016.182

The inadequate transport of drugs into the tumor tissue caused by its abnormal vasculature is a major obstacle to the treatment of cancer. Anti-vascular endothelial growth factor (anti-VEGF) drugs can cause phenotypic alteration and maturation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8777a0ad8aeebff2ef297f59590917
https://pubmed.ncbi.nlm.nih.gov/27270432