Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

Autor: C. David Owen, Louise E. Tailford, Serena Monaco, Tanja Šuligoj, Laura Vaux, Romane Lallement, Zahra Khedri, Hai Yu, Karine Lecointe, John Walshaw, Sandra Tribolo, Marc Horrex, Andrew Bell, Xi Chen, Gary L. Taylor, Ajit Varki, Jesus Angulo, Nathalie Juge

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

The mucus layer is an important physical niche within the gut which harbours a distinct microbial community. Here the authors show that specific carbohydrate-binding modules associated with bacterial carbohydrate-active enzymes are mucus adhesins tha

Externí odkaz: https://doaj.org/article/a9e2f73219e849be977339d14d916fea

Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives

Autor: Louise E. Tailford, Gwénaëlle Le Gall, Simone Dedola, Sandra Tribolo, Robert A. Field, Dimitrios Latousakis, Xi Chen, Marie Monestier, Martin Rejzek, Hai Yu, Andrew Bell, Nathalie Juge, Ian J. Colquhoun

Publikováno v: Monestier, M, Latousakis, D, Bell, A, Tribolo, S, Tailford, L E, Colquhoun, I J, Gall, G L, Yu, H, Chen, X, Rejzek, M, Dedola, S, Field, R A & Juge, N 2017, ' Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives ', Carbohydrate Research . https://doi.org/10.1016/j.carres.2017.08.008
Carbohydrate Research

Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases). A facile one-pot two-enzyme approach has been established for the synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8cbe9571741c158b1e7b8429559532
https://doi.org/10.1016/j.carres.2017.08.008

Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery

Autor: David A. Hughes, Moira A. Taylor, Sandra Tribolo, Paul W. Needs, Paul A. Kroon, V. G. Wilson, Sunita Suri, Salmin Alshalmani

Publikováno v: British Journal of Pharmacology. 162:1485-1497

BACKGROUND AND PURPOSE Quercetin is anti-inflammatory in macrophages by inhibiting lipopolysaccharide (LPS)-mediated increases in cytokine and nitric oxide production but there is little information regarding the corresponding effect on the vasculatu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13671114671dcd9129b7b3ac1ca70859
https://doi.org/10.1111/j.1476-5381.2010.00919.x

Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells

Autor: Mark S. Winterbone, David A. Hughes, Paul A. Kroon, Paul W. Needs, Sandra Tribolo

Publikováno v: Atherosclerosis. 202:431-438

Dietary flavonoids have been shown to have a number of anti-inflammatory properties, including decreasing the expression of adhesion molecules. Flavonoids however, are metabolised during absorption and the forms reaching the systemic circulation are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121cdb6a65982736b40db2295d74bb34
https://doi.org/10.1016/j.atherosclerosis.2008.04.040

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells

Autor: David A. Hughes, Sandra Tribolo, Federica Lodi, Paul W. Needs, Moira A. Taylor, Sunita Suri, Carol Connor, Paul A. Kroon, V. G. Wilson

Publikováno v: Atherosclerosis. 197:50-56

Adhesion of circulating monocytes to vascular endothelial cells, a critical step in both inflammation and atherosclerosis, is mediated by cross-linkage of adhesion molecules expressed on the surface of both cell types. Dietary flavonoids have been sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be0f5f27c7096e8b7d2eacc1fbc7bfa
https://doi.org/10.1016/j.atherosclerosis.2007.07.040