Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sandra, Schrenk"'
MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ
Autor:
Sandra Schrenk, Lindsay J. Bischoff, Jillian Goines, Yuqi Cai, Shruti Vemaraju, Yoshinobu Odaka, Samantha R. Good, Joseph S. Palumbo, Sara Szabo, Damien Reynaud, Catherine D. Van Raamsdonk, Richard A. Lang, Elisa Boscolo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Life-threatening vascular tumors can be associated with uncontrolled activity of the guanine nucleotide-binding protein subunit alpha (Gαq). Here, the authors develop a murine model for these tumors and show that MEK inhibition prevents formation of
Externí odkaz:
https://doaj.org/article/7cad600490c342d6b140a087bcb306ca
Autor:
Sandra Schrenk, Elisa Boscolo
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Propranolol is a nonselective β-adrenergic receptor (AR) blocker that has been the first-line therapy for problematic infantile hemangioma (IH), the most frequent childhood vascular tumor. Although IHs are benign and eventually regress spontaneously
Externí odkaz:
https://doaj.org/article/aaedc92cc0a14e329b1c74d33cc791ce
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM). Gain-of-function mutations in the tyros
Externí odkaz:
https://doaj.org/article/d60729f8db694524a763b01f44aa65cc
Autor:
Monica Piccione, Nicola Facchinello, Sandra Schrenk, Marco Gasparella, Surajit Pathak, Ramy M. Ammar, Sabine Rabini, Luisa Dalla Valle, Rosa Di Liddo
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1234 (2021)
Aim: Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by chronic abdominal pain and stool irregularities. STW 5 has proven clinical efficacy in functional gastrointestinal disorders, including IBS, targeting pathways that s
Externí odkaz:
https://doaj.org/article/c46588f2183948e0bd04737b2553468f
Autor:
Elisa Boscolo, Patricia Pastura, Sandra Schrenk, Jillian Goines, Rachael Kang, Devin Pillis, Punam Malik, Timothy D. Le Cras
Publikováno v:
Angiogenesis. 25:331-342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7064664e88f9f0520fd4cb852f6cc832
https://doi.org/10.1007/s10456-022-09836-7
https://doi.org/10.1007/s10456-022-09836-7
Autor:
Rosa Di Liddo, Marco Verona, Christian Vaccarin, Laura Acquasaliente, Sandra Schrenk, Monica Piccione, Carola Cenzi, Michele De Franco, Matteo Dal Prà, Giovanni Ribaudo, Maria Grazia Ferlin, Maria Teresa Conconi, Adriana Chilin, Valentina Gandin, Giovanni Marzaro
Publikováno v:
Cancers, 14 (15)
Simple Summary The Epidermal Growth Factor Receptor (EGFR) is a receptor protein involved in many types of cancers. EGFR can be inhibited by monoclonal antibodies (protein drugs acting on the extracellular domain of the protein) or by ATP-mimic compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9b330b50e84a06e3ac8870d5bfa410
http://hdl.handle.net/11577/3455167
http://hdl.handle.net/11577/3455167
Autor:
Sabine Rabini, Surajit Pathak, Sandra Schrenk, Nicola Facchinello, Ramy M. Ammar, Luisa Dalla Valle, Marco Gasparella, Rosa Di Liddo, Monica Piccione
Publikováno v:
Pharmaceuticals; Volume 14; Issue 12; Pages: 1234
Pharmaceuticals, Vol 14, Iss 1234, p 1234 (2021)
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 1234, p 1234 (2021)
Pharmaceuticals
Aim: Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by chronic abdominal pain and stool irregularities. STW 5 has proven clinical efficacy in functional gastrointestinal disorders, including IBS, targeting pathways that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c9c73b9fd34c71ab0e18233a63bd89
Autor:
Elisa, Boscolo, Patricia, Pastura, Sandra, Schrenk, Jillian, Goines, Rachael, Kang, Devin, Pillis, Punam, Malik, Timothy D, Le Cras
Publikováno v:
Angiogenesis
Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. The goals of this study were to determine whether the somatic-activating NRAS(Q61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be78c0ad8a39011de89b237b5ecea5fc
https://pubmed.ncbi.nlm.nih.gov/35391614
https://pubmed.ncbi.nlm.nih.gov/35391614
Publikováno v:
J Vis Exp
Venous malformation (VM) is a vascular anomaly that arises from impaired development of the venous network resulting in dilated and often dysfunctional veins. The purpose of this article is to carefully describe the establishment of a murine xenograf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a76be107c3aad71862e8e417d1788b7
https://doi.org/10.3791/61501-v
https://doi.org/10.3791/61501-v
Autor:
Pier Paolo Parnigotto, Rosa Di Liddo, Maria Teresa Conconi, Alessio Borean, Alberto Argentoni, Carola Cenzi, Sandra Schrenk, Ivan Pirola, Thomas Bertalot, Stefano Capelli
Publikováno v:
Journal of Cellular and Molecular Medicine
The wound healing is a complex process wherein inflammation, proliferation and regeneration evolve according to a spatio‐temporal pattern from the activation of coagulation cascade to the formation of a plug clot including fibrin matrix, blood‐bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bac087588f8ba3a0d39fbc8e000281
https://doi.org/10.1111/jcmm.13468
https://doi.org/10.1111/jcmm.13468