CenTauR: Toward a universal scale and masks for standardizing tau imaging studies

Autor: Victor L. Villemagne, Antoine Leuzy, Sandra Sanabria Bohorquez, Santiago Bullich, Hitoshi Shimada, Christopher C. Rowe, Pierrick Bourgeat, Brian Lopresti, Kun Huang, Natasha Krishnadas, Jurgen Fripp, Yuhei Takado, Alexandra Gogola, Davneet Minhas, Robby Weimer, Makoto Higuchi, Andrew Stephens, Oskar Hansson, Vincent Doré, Alzheimer's Disease Neuroimaging Initiative and the AIBL research group

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023)

Abstract INTRODUCTION Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them

Externí odkaz: https://doaj.org/article/e3a442eac9e64af3bc0f3fc0565a03c8

Safety and Efficacy of Semorinemab in Individuals with Prodromal to Mild Alzheimer Disease

Autor: Edmond, Teng, Paul T, Manser, Karen, Pickthorn, Flavia, Brunstein, Mira, Blendstrup, Sandra, Sanabria Bohorquez, Kristin R, Wildsmith, Bali, Toth, Michael, Dolton, Vidya, Ramakrishnan, Ashwini, Bobbala, Sietske A M, Sikkes, Michael, Ward, Reina N, Fuji, Geoffrey A, Kerchner, David, Weisman

Publikováno v: JAMA Neurology, 79(8), 758-767. American Medical Association
Teng, E, Manser, P T, Pickthorn, K, Brunstein, F, Blendstrup, M, Sanabria Bohorquez, S, Wildsmith, K R, Toth, B, Dolton, M, Ramakrishnan, V, Bobbala, A, Sikkes, S A M, Ward, M, Fuji, R N & Kerchner, G A 2022, ' Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease : A Randomized Clinical Trial ', JAMA Neurology, vol. 79, no. 8, pp. 758-767 . https://doi.org/10.1001/jamaneurol.2022.1375
Teng, E, Manser, P T, Pickthorn, K, Brunstein, F, Blendstrup, M, Sanabria Bohorquez, S, Wildsmith, K R, Toth, B, Dolton, M, Ramakrishnan, V, Bobbala, A, Sikkes, S A M, Ward, M, Fuji, R N & Kerchner, G A 2022, ' Safety and Efficacy of Semorinemab in Individuals with Prodromal to Mild Alzheimer Disease : A Randomized Clinical Trial ', JAMA Neurology, vol. 79, no. 8, pp. 758-767 . https://doi.org/10.1001/jamaneurol.2022.1375

Importance: Neurofibrillary tangles composed of aggregated tau protein are one of the neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical disease severity. Monoclonal antibodies targeting tau may have the potential to am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5221ef4dd6e70490909446ed6b1ce80
http://www.scopus.com/inward/record.url?scp=85132835366&partnerID=8YFLogxK

Evaluation of Longitudinal [18F]GTP1 Tau Burden Metrics in the Tauriel Phase II Study

Autor: Sandra Sanabria Bohorquez, Paul T Manser, Suzanne L. Baker, Mira Blendstrup, Karen Pickthorn, Edmond Teng

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5968dfcfb33d220705130344ab842c20
https://doi.org/10.1002/alz.061266

In Vivo Head‐To‐Head Comparison of [ 18 F]GTP1 and [ 18 F]PI2620 in Alzheimer’s Disease

Autor: Sandra Sanabria Bohorquez, Cristian Constantinescu, Paul T Manser, Roger N Gunn, David S Russell, Matteo Tonietto, Santiago Bullich, Andrew W Stephens, Andre Mueller, Gregory Klein, Edmond Teng, Karen Pickthorn

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c013ed02a98a17e514c717516af4785f
https://doi.org/10.1002/alz.063513

Preclinical development of ZED8, an

Autor: Annie, Ogasawara, James R, Kiefer, Herman, Gill, Eugene, Chiang, Shravan, Sriraman, Gregory Z, Ferl, James, Ziai, Sandra Sanabria, Bohorquez, Sebastian, Guelman, Xiangdan, Wang, Jihong, Yang, Minh Michael, Phan, Van, Nguyen, Shan, Chung, Christine, Yu, Jeff, Tinianow, Stijn Jan Hein, Waaijer, Alex, De Crespigny, Jan, Marik, C Andrew, Boswell, Tanja, Zabka, Karin, Staflin, Simon-Peter, Williams

Publikováno v: European journal of nuclear medicine and molecular imaging. 50(2)

ZED8 is a novel monovalent antibody labeled with zirconium-89 for the molecular imaging of CD8. This work describes nonclinical studies performed in part to provide rationale for and to inform expectations in the early clinical development of ZED8, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31e464b63e7f56aaa5305457496e7b95
https://pubmed.ncbi.nlm.nih.gov/36427067