Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sandra, Lightle"'
Autor:
Ron Sarver, Christopher Whitehead, Heidi Baum, James Hicks, Richard Gowan, Brian Sanchez, Xiao Kang Lu, Susan E. Bove, Joseph A. Cornicelli, Howard Miller, Sandra Lightle, Aurash B Shahripour, Katherine Welch, Craig Banotai, Jayvardhan Pandit, Mark S. Plummer, Timothy Braden, David Beidler, Adam Ogden, Skalitzky Donald James, Annise Paige Goodman, Howard Roark, Nalini Sadagopan, Charles J. Stankovic, Cindy Spessard, Xi Qiang Shen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3438-3442
We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of PDE4 inhibitors, while simultaneously minimizing PDE4 activity. These newly designed PDE2 inhibitors bind to the PDE2 enzyme in a cGMP-like mode in co
Autor:
Skalitzky Donald James, Craig Banotai, Jayvardhan Pandit, Adam Ogden, James Hicks, Annise Paige Goodman, Xiao Kang Lu, Howard Miller, Howard Roark, Susan E. Bove, Sandra Lightle, Aurash B Shahripour, Timothy Braden, Mark S. Plummer, Katherine Welch, Charles J. Stankovic, Ron Sarver, Joseph A. Cornicelli, Christopher Whitehead, Brian Sanchez, Nalini Sadagopan, Heidi Baum, Richard Gowan, David Beidler, Xi Qiang Shen, Cindy Spessard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3443-3447
Selective phosphodiesterase 2 (PDE2) inhibitors are shown to have efficacy in a rat model of osteoarthritis (OA) pain. We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of phosphodiesterase 4 (PDE4) inhi
Autor:
John D. Knafels, Chris Limberakis, Paul J. Pagano, Murphy Sean T, Joseph S. Warmus, Sandra Lightle, Daniel F. Ortwine, Joel C. Bronstein, Terry Podoll, Clarke Taylor, Igor Mochalkin, Johnson Timothy Allan, Cheryl L. Quinn, Roger J. Brideau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2536-2543
Lipid A is an essential component of the Gram negative outer membrane, which protects the bacterium from attack of many antibiotics. The Lipid A biosynthesis pathway is essential for Gram negative bacterial growth and is unique to these bacteria. The
Autor:
Serdar Aykent, Oliphant Theodore Lawrence, Kristine Wells, Nathan A. Lacher, Sandra Lightle, Vesselin Mitaksov, James F. Zobel
Publikováno v:
Protein Science. 19:753-762
Human IgG2 antibodies may exist in at least three distinct structural isomers due to disulfide shuffling within the upper hinge region. Antibody interactions with Fc gamma receptors and the complement component C1q contribute to immune effector funct
Autor:
Thomas L. Emmons, James R. Kiefer, Joseph W. Leone, John F. Schindler, Melissa S. Harris, Jacqueline E. Day, Siradanahalli Guru, Alfredo G. Tomasselli, Robin A. Weinberg, Sandra Lightle, H. David Fischer, Jeffrey L. Hirsch, Jill Chrencik, Jennifer A. Gormley, Jennifer M. Williams, Matthew J. Saabye, Troii Hall
Publikováno v:
Protein Expression and Purification. 69:54-63
Janus-associated kinases (JAKs) play critical roles in cytokine signaling, and have emerged as viable therapeutic targets in inflammation and oncology related diseases. To date, targeting JAK proteins with highly selective inhibitor compounds have re
Autor:
Artem G. Evdokimov, Charles Ken Stover, J. Richard Miller, Grover L. Waldrop, Chunhong Yan, Sandra Lightle, Igor Mochalkin
Publikováno v:
Protein Science. 17:1706-1718
Bacterial acetyl-CoA carboxylase is a multifunctional biotin-dependent enzyme that consists of three separate proteins: biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP), and carboxyltransferase (CT). Acetyl-CoA carboxylase is a potenti
Autor:
Igor Mochalkin, Sandra Lightle, Michael Melnick, Craig Banotai, Yaqi Zhu, Cindy Spessard, Nickolay Y. Chirgadze, Laura McDowell, Jeffrey F. Ohren
Publikováno v:
Protein Science. 16:2657-2666
N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU) catalyzes the first step in peptidoglycan biosynthesis in both Gram-positive and Gram-negative bacteria. The products of the GlmU reaction are essential for bacterial survival, making this enzy
Autor:
Bill Dunkle, Steve A. Dunham, Andrea J Gonzales, Lisa M. Bergeron, John A. Shelly, Yaqi Zhu, Graeme Bainbridge, Erin E. McCandless, Sandra Lightle
Publikováno v:
Veterinary immunology and immunopathology. 157(1-2)
To date, very little is known about the functional characteristics of the four published canine IgG subclasses. It is not clear how each subclass engages the immune system via complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediate
Autor:
Sandra, Lightle, Serdar, Aykent, Nathan, Lacher, Vesselin, Mitaksov, Kristine, Wells, James, Zobel, Theodore, Oliphant
Publikováno v:
Protein science : a publication of the Protein Society. 19(4)
Human IgG2 antibodies may exist in at least three distinct structural isomers due to disulfide shuffling within the upper hinge region. Antibody interactions with Fc gamma receptors and the complement component C1q contribute to immune effector funct
Autor:
C. Kendall Stover, J. Richard Miller, Sandra Lightle, Venkataraman Thanabal, Igor Mochalkin, Michael D. Huband, Lakshmi Narasimhan, Philip B. Cox, Paul Erdman, J.V.N. Vara Prasad
Publikováno v:
ACS chemical biology. 4(6)
As part of our effort to inhibit bacterial fatty acid biosynthesis through the recently validated target biotin carboxylase, we employed a unique combination of two emergent lead discovery strategies. We used both de novo fragment-based drug discover