Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sandra, I Mota"'
Autor:
Carla Cavaleiro, Gonçalo J. M. Afonso, Paulo J. Oliveira, Jorge Valero, Sandra I. Mota, Elisabete Ferreiro
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Stem cells have potential applications in the field of neurological diseases, as they allow for the development of new biological models. These models can improve our understanding of the underlying pathologies and facilitate the screening of new the
Externí odkaz:
https://doaj.org/article/5f44eda08b554d15a0a3d87b78776a91
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1770 (2023)
Soluble Aβ1–42 oligomers (AβO) are formed in the early stages of Alzheimer’s disease (AD) and were previously shown to trigger enhanced Ca2+ levels and mitochondrial dysfunction via the activation of N-methyl-D-aspartate receptors (NMDAR). Src
Externí odkaz:
https://doaj.org/article/d32e3e99bf4a4f30843867bc52c79642
Autor:
Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102424- (2022)
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and
Externí odkaz:
https://doaj.org/article/41a596c6e228444184c1c9a70b5c8a8a
Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
Publikováno v:
Cells, Vol 12, Iss 13, p 1763 (2023)
Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogenei
Externí odkaz:
https://doaj.org/article/46b27564dcdd466c902b9d7006218aa4
Autor:
Frederico C. Pereira, Rodolfo Águas, Inês R. Pita, A. Cristina Rego, Slah Tagorti, Ashraf Virmani, Sandra I. Mota
Publikováno v:
Archives of Toxicology. 95:2769-2784
Mitochondrial deregulation has emerged as one of the earliest pathological events in Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder. Improvement of mitochondrial function in AD has been considered a relevant therap
Autor:
Lígia Fão, Patrícia Coelho, Luís Duarte, Rita Vilaça, Michael R. Hayden, Sandra I. Mota, Ana Cristina Rego
Publikováno v:
Antioxidantsredox signaling.
Autor:
Ana Cristina Rego, Philip T. T. Ly, Noga Gershoni-Emek, Leonard A. Levin, Luana Naia, Sandra I. Mota, Michael R. Hayden, Michal Geva
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes
Autor:
Carla Lopes, Sandra I. Mota, Michael R. Hayden, Marina Shenkman, Gerardo Z Lederkreme, Michal Geva, Noga Gershoni Emek, Luana Naia, A. Cristina Rego, Philip T. T. Ly, Maria Ankarcrona
Publikováno v:
I: Experimental therapeutics – preclinical.
Background Pridopidine is a highly selective, potent Sigma-1 receptor (S1R) agonist in clinical development for HD and ALS. The S1R is a protein enriched at the endoplasmic reticulum (ER)-mitochondria interface and vital to multiple cellular mechanis
Autor:
Luana Naia, Maria Ankarcrona, Michael R. Hayden, Carla Lopes, A. Cristina Rego, Michal Geva, Carina Maranga, Patrícia Coelho, Noga Gershoni-Emek, Philip T. T. Ly, Sandra I. Mota
Publikováno v:
Neurotherapeutics
Pridopidine is a selective Sigma-1 receptor (S1R) agonist in clinical development for Huntington disease (HD) and amyotrophic lateral sclerosis. S1R is a chaperone protein localized in mitochondria-associated endoplasmic reticulum (ER) membranes, a s
Autor:
Sandra I, Mota, Inês, Pita, Rodolfo, Águas, Slah, Tagorti, Ashraf, Virmani, Frederico C, Pereira, A Cristina, Rego
Publikováno v:
Archives of toxicology. 95(8)
Mitochondrial deregulation has emerged as one of the earliest pathological events in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. Improvement of mitochondrial function in AD has been considered a relevant therapeu