Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

Autor: Rodolphe Dusaulcy, Chloé Rancoule, Sandra Grès, Estelle Wanecq, André Colom, Charlotte Guigné, Laurens A. van Meeteren, Wouter H. Moolenaar, Philippe Valet, Jean Sébastien Saulnier-Blache

Publikováno v: Journal of Lipid Research, Vol 52, Iss 6, Pp 1247-1255 (2011)

Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). ATX is secreted by adipose tissue and its expression is enhanced in obese/insulin-resistant individuals. Here, we analyzed the specific c

Externí odkaz: https://doaj.org/article/e5ac99397ff44ed8be0927e7dbf10e8b

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.

Autor: Marion David, Estelle Wannecq, Françoise Descotes, Silvia Jansen, Blandine Deux, Johnny Ribeiro, Claire-Marie Serre, Sandra Grès, Nathalie Bendriss-Vermare, Mathieu Bollen, Simone Saez, Junken Aoki, Jean-Sébastien Saulnier-Blache, Philippe Clézardin, Olivier Peyruchaud

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9741 (2010)

Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatments using powerful anti-resorptive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progressi

Externí odkaz: https://doaj.org/article/7845bd0a186844a298c4435a219c66b9

Autotaxin Downregulates LPS-Induced Microglia Activation and Pro-Inflammatory Cytokines Production

Autor: Rana Awada, G. Jean Harry, Christian Lefebvre d'Hellencourt, Ruben Orihuela, Sandra Grès, Jean Sébastien Saulnier-Blache, Philippe Rondeau, Emmanuel Bourdon, Avinash Parimisetty

Publikováno v: Journal of Cellular Biochemistry. 115:2123-2132

Inflammation is essential in defense against infection or injury. It is tightly regulated, as over-response can be detrimental, especially in immune-privileged organs such as the central nervous system (CNS). Microglia constitutes the major source of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7404c2954b6e8f6dccf94997cfe534e6
https://doi.org/10.1002/jcb.24889

Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: In vivo and in vitro evidence

Autor: Jean-Loup Bascands, Pauline Decaunes, Philippe Valet, Chloé Rancoule, Jean Sébastien Saulnier-Blache, Sandra Grès, Nathalie Viguerie, Manon Viaud, Anne Bouloumié, Dominique Langin

Publikováno v: BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2014, 1841 (1), pp.88-96. ⟨10.1016/j.bbalip.2013.10.003⟩
BBA-Biochimica et Biophysica Acta, 2014, 1841 (1), pp.88-96. ⟨10.1016/j.bbalip.2013.10.003⟩

International audience; Lysophosphatidic acid (LPA) is a pro-fibrotic mediator acting via specific receptors (LPARs) and is synthesized by autotaxin, that increases with obesity. We tested whether LPA could play a role in adipose tissue (AT)-fibrosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739526a14a7c7dfc053c5f8a24523fd9
https://doi.org/10.1016/j.bbalip.2013.10.003

Influence of secreted factors from human adipose tissue on glucose utilization and proinflammatory reaction

Autor: Philippe Valet, Karine Tréguer, Sandra Grès, Jean Sébastien Saulnier-Blache, Estelle Wanecq, R. Dusaulcy

Publikováno v: Journal of Physiology and Biochemistry. 69:625-632

The objective of the present study was to characterize the nature of the autocrine/paracrine signal within human adipose tissue that may alter glucose metabolism and the inflammatory status in adipocytes. We prepared a conditioned medium from abdomin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8ea8fd090a02c29107dfe15f97f478
https://doi.org/10.1007/s13105-013-0238-7