Zobrazeno 1 - 10 of 82 pro vyhledávání: '"Sandra, Goebbels"'
1
Akademický článek
Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases
Autor: Doris Krauter, Daniela Stausberg, Timon J Hartmann, Stefan Volkmann, Theresa Kungl, David A Rasche, Gesine Saher, Robert Fledrich, Ruth M Stassart, Klaus-Armin Nave, Sandra Goebbels, David Ewers, Michael W Sereda
Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 3, Pp 616-640 (2024)
Abstract Haplo-insufficiency of the gene encoding the myelin protein PMP22 leads to focal myelin overgrowth in the peripheral nervous system and hereditary neuropathy with liability to pressure palsies (HNPP). Conversely, duplication of PMP22 causes
Externí odkaz: https://doaj.org/article/7fd4960236094ab48972800c5f7528ba
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2
Akademický článek
Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice
Autor: Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner
Publikováno v: eLife, Vol 11 (2022)
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar. Here, we use quantit
Externí odkaz: https://doaj.org/article/4e5b92e78c254760b002c60c7dec1836
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4
Akademický článek
Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction
Autor: Julia Patzig, Michelle S Erwig, Stefan Tenzer, Kathrin Kusch, Payam Dibaj, Wiebke Möbius, Sandra Goebbels, Nicole Schaeren-Wiemers, Klaus-Armin Nave, Hauke B Werner
Publikováno v: eLife, Vol 5 (2016)
Myelination of axons facilitates rapid impulse propagation in the nervous system. The axon/myelin-unit becomes impaired in myelin-related disorders and upon normal aging. However, the molecular cause of many pathological features, including the frequ
Externí odkaz: https://doaj.org/article/e5e4e375aa0b4e2a9baa3f4bceaac43f
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6
Lysosomal storage disease associated with a CNP sequence variant in Dalmatian dogs
Autor: Garrett Bullock, Gary S. Johnson, Tendai Mhlanga-Mutangadura, Scott C. Petesch, Samantha Thompson, Sandra Goebbels, Martin L. Katz
Publikováno v: Gene
A progressive neurological disorder was identified in purebred Dalmatian dogs. The disease is characterized by anxiety, pacing and circling, hypersensitivity, cognitive decline, sleep disturbance, loss of coordination, loss of control over urination
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bde2c087fa864dbc36b571be77a4fa
https://pubmed.ncbi.nlm.nih.gov/35447247
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7
Inversely proportional myelin growth due to altered Pmp22 gene dosage identifies PI3K/Akt/mTOR signaling as a novel therapeutic target in HNPP
Autor: Sandra Goebbels, Robert Fledrich, Michael W. Sereda, Doris Krauter, Klaus-Armin Nave, Theresa Kungl, David Ewers, Stefan Volkmann, Timon J Hartmann
Duplication of the gene encoding the myelin protein PMP22 causes the hereditary neuropathy Charcot-Marie-Tooth disease 1A (CMT1A), characterized by hypomyelination of medium to large caliber peripheral axons. Conversely, haplo-insufficiency of PMP22
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a2f356c45a4835ce2af5a9e2637d240
https://doi.org/10.1101/2021.11.08.467756
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8
Akademický článek
The polarity protein Scribble regulates myelination and remyelination in the central nervous system.
Autor: Andrew A Jarjour, Amanda Boyd, Lukas E Dow, Rebecca K Holloway, Sandra Goebbels, Patrick O Humbert, Anna Williams, Charles ffrench-Constant
Publikováno v: PLoS Biology, Vol 13, Iss 3, p e1002107 (2015)
The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), requires profound changes in cell shape that lead to myelin sheath initiation and formation. Here, we demonstrate a requirem
Externí odkaz: https://doaj.org/article/66807c3dc1214268828929b4e77180c2
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9
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines
Autor: Ariane Pereira, Jeff A. Stogsdill, Gesine Saher, Peter Scheiffele, Lisa Traunmüller, Klaus-Armin Nave, Jiexin Wang, Chris J. McBain, Naosuke Hoshina, Huda Y. Zoghbi, Yu Itoh-Maruoka, Cagla Eroglu, Wei-Hsiang Huang, Fritz Benseler, Thomas Philips, Constance L. Cepko, Mateusz C. Ambrozkiewicz, Jeremy N. Kay, Hiroshi Kawabe, Vania F. Prado, Kevin T. Beier, Wenjia You, Nils Brose, Harold A. Burgess, Wei Lu, Junko Motohashi, Pascal S. Kaeser, Liqun Luo, Marco A. M. Prado, Elisabetta Furlanis, Emily Ling-Lin Pai, Kenji Sakimura, Kenji Mandai, John L.R. Rubenstein, Andrea M. Gomez, Emilie Dumontier, Michisuke Yuzaki, Hisashi Umemori, Yoshimi Takai, Jean-François Cloutier, Susanne Falkner, Laura A. Lavery, Sandra Goebbels, Matthijs Verhage, Ann Marie Craig, Cui Chen, Kenneth A. Pelkey, Wei Li, Nashat Abumaria, Joshua R. Sanes, Lin Luo, Jeffrey D. Rothstein, Joke Wortel, Jennifer L. Sinclair, Mary Anne Hutchison, Tomohiko Maruo
Publikováno v: Neuron, vol 106, iss 1
Luo, L, Ambrozkiewicz, M C, Benseler, F, Chen, C, Dumontier, E, Falkner, S, Furlanis, E, Gomez, A M, Hoshina, N, Huang, W H, Hutchison, M A, Itoh-Maruoka, Y, Lavery, L A, Li, W, Maruo, T, Motohashi, J, Pai, E L L, Pelkey, K A, Pereira, A, Philips, T, Sinclair, J L, Stogsdill, J A, Traunmüller, L, Wang, J, Wortel, J, You, W, Abumaria, N, Beier, K T, Brose, N, Burgess, H A, Cepko, C L, Cloutier, J F, Eroglu, C, Goebbels, S, Kaeser, P S, Kay, J N, Lu, W, Luo, L, Mandai, K, McBain, C J, Nave, K A, Prado, M A M, Prado, V F, Rothstein, J, Rubenstein, J L R, Saher, G, Sakimura, K, Sanes, J R, Scheiffele, P, Takai, Y, Umemori, H, Verhage, M, Yuzaki, M, Zoghbi, H Y, Kawabe, H & Craig, A M 2020, ' Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines : Prevalence of Germline Recombination and Influencing Factors ', Neuron, vol. 106, no. 1, pp. 37-65.e5 . https://doi.org/10.1016/j.neuron.2020.01.008
Neuron, 106(1), 37-65.e5. Cell Press
Neuron
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0d62fde17242aab3eee01b2747766
https://doi.org/10.1016/j.neuron.2020.01.008
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10
NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum
Autor: Alexander Pieper, Tilmann Götze, Ulli Bode, Sandra Goebbels, Georg L. Wieser, Jacques I. Wadiche, Kuo Yan, Hendrik Mießner, Ingo Bormuth, Markus H. Schwab, Bettina Duverge Castillo, Stephanie Rudolph, Tomoko Yonemasu, Iva D. Tzvetanova
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
The cerebellar cortex is involved in the control of diverse motor and non-motor functions. Its principal circuit elements are the Purkinje cells that integrate incoming excitatory and local inhibitory inputs and provide the sole output of the cerebel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e14f074070e19019509b9e2e5268a9
http://link.springer.com/article/10.1038/s41598-018-37850-7
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