The ribosome profiling landscape of yeast reveals a high diversity in pervasive translation

Autor: Chris Papadopoulos, Hugo Arbes, David Cornu, Nicolas Chevrollier, Sandra Blanchet, Paul Roginski, Camille Rabier, Safiya Atia, Olivier Lespinet, Olivier Namy, Anne Lopes

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)

Abstract Background Pervasive translation is a widespread phenomenon that plays a critical role in the emergence of novel microproteins, but the diversity of translation patterns contributing to their generation remains unclear. Based on 54 ribosome

Externí odkaz: https://doaj.org/article/ff8383a10fe44922aa7eb3904d0b8ed6

The Ribosome Profiling landscape of yeast reveals a high diversity in pervasive translation

Autor: Chris Papadopoulos, Hugo Arbes, Nicolas Chevrollier, Sandra Blanchet, David Cornu, Paul Roginski, Camille Rabier, Safiya Atia, Olivier Lespinet, Olivier Namy, Anne Lopes

Pervasive translation is a widespread phenomenon that plays an important role in de novo gene birth; however, its underlying mechanisms remain unclear. Based on multiple Ribosome Profiling (Ribo-Seq) datasets, we investigated the RiboSeq landscape of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35e06f180bcc5f7f4dd5d917cda3ecd7
https://doi.org/10.1101/2023.03.16.532990

Translation Phases in Eukaryotes

Autor: Sandra, Blanchet, Namit, Ranjan

Publikováno v: Ribosome Biogenesis ISBN: 9781071625002
Methods Mol Biol

Protein synthesis in eukaryotes is carried out by 80S ribosomes with the help of many specific translation factors. Translation comprises four major steps: initiation, elongation, termination, and ribosome recycling. In this review, we provide a comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c53daee05d0a87da767f6653d33915
https://doi.org/10.1007/978-1-0716-2501-9_13

Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation

Autor: Bertrand Beckert, Namit Ranjan, Daniel N. Wilson, Agnieszka A. Pochopien, Colin Chih Chien Wu, Rachel Green, Sandra Blanchet, Marina V. Rodnina

Publikováno v: The EMBO Journal
EMBO Journal

In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the ribosomal A and E sites, its exact mechanism of act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f380a8619fc4a7420cf13128043d8f1c
https://pubmed.ncbi.nlm.nih.gov/33555093

Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons

Autor: Isabelle Sermet-Gaudelus, Laure Bidou, Emmanuelle Girodon, Benoit Chevalier, Alexandre Hinzpeter, Iwona Pranke, Aurélie Hatton, Danielle Tondelier, Sabrina Karri, Natacha Martin, Matthieu Coupet, Pascale Fanen, Aleksander Edelman, Bruno Costes, David Cornu, Sandra Blanchet, Olivier Namy

Publikováno v: ERJ Open Research
ERJ Open Research, European Respiratory Society, 2018, 4 (1), pp.00080-2017. ⟨10.1183/23120541.00080-2017⟩
ERJ Open Research, Vol 4, Iss 1 (2018)
ERJ Open Research, 2018, 4 (1), pp.00080-2017. ⟨10.1183/23120541.00080-2017⟩

Premature termination codons (PTCs) are generally associated with severe forms of genetic diseases. Readthrough of in-frame PTCs using small molecules is a promising therapeutic approach. Nonetheless, the outcome of preclinical studies has been low a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858be3aea6160908c2c8690a760cb3be
https://hal.archives-ouvertes.fr/hal-02145353