Spike-heparan sulfate interactions in SARS-CoV-2 infection

Autor: Kearns, Fiona L., Sandoval, Daniel R., Casalino, Lorenzo, Clausen, Thomas M., Rosenfeld, Mia A., Spliid, Charlotte B., Amaro, Rommie E., Esko, Jeffrey D.

Publikováno v: In Current Opinion in Structural Biology October 2022 76

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Autor: Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Perrett, Hailee R., Painter, Chelsea D., Narayanan, Anoop, Majowicz, Sydney A., Kwong, Elizabeth M., McVicar, Rachael N., Thacker, Bryan E., Glass, Charles A., Yang, Zhang, Torres, Jonathan L., Golden, Gregory J., Bartels, Phillip L., Porell, Ryan N., Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake M., Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Chanda, Sumit K., Schmidt, Aaron G., Godula, Kamil, Leibel, Sandra L., Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.

Publikováno v: In Cell 12 November 2020 183(4):1043-1057

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Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates

Autor: Karlsson, Richard, Chopra, Pradeep, Joshi, Apoorva, Yang, Zhang, Vakhrushev, Sergey Y, Clausen, Thomas Mandel, Painter, Chelsea D, Szekeres, Gergo P, Chen, Yen-Hsi, Sandoval, Daniel R, Hansen, Lars, Esko, Jeffrey D, Pagel, Kevin, Dyer, Douglas P, Turnbull, Jeremy E, Clausen, Henrik, Boons, Geert-Jan, Miller, Rebecca L, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery

Publikováno v: Science Advances
Karlsson, R, Chopra, P, Joshi, A, Yang, Z, Vakhrushev, S Y, Clausen, T M, Painter, C D, Szekeres, G P, Chen, Y H, Sandoval, D R, Hansen, L, Esko, J D, Pagel, K, Dyer, D P, Turnbull, J E, Clausen, H, Boons, G J & Miller, R L 2021, ' Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates ', Science Advances, vol. 7, no. 52, eabl6026 . https://doi.org/10.1126/sciadv.abl6026
Science advances, 7(52), 1. American Association for the Advancement of Science
Karlsson, R, Chopra, P, Joshi, A, Yang, Z, Vakhrushev, S Y, Clausen, T M, Painter, C D, Szekeres, G P, Chen, Y-H, Sandoval, D R, Hansen, L, Esko, J D, Pagel, K, Dyer, D P, Turnbull, J E, Clausen, H, Boons, G-J & Miller, R L 2021, ' Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates ', Science Advances, vol. 7, no. 52, eabl6026, pp. eabl6026 . https://doi.org/10.1126/sciadv.abl6026
Science advances, vol 7, iss 52

Description
This study provides proof of concept for cell-based heparin without heparin-induced thrombocytopenia side effects.
Heparan sulfate (HS) polysaccharides are master regulators of diverse biological processes via sulfated motifs th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a0544d330ab0c9b3e70289c090c827
https://pubmed.ncbi.nlm.nih.gov/34936441

sj-pdf-1-jhc-10.1177_0022155420988661 – Supplemental material for A Systems View of the Heparan Sulfate Interactome

Autor: Schaefer, Liliana, Frevert, Charles W., Toledo, Alejandro Gómez, Sorrentino, James T., Sandoval, Daniel R., Malmström, Johan, Lewis, Nathan E., Esko, Jeffrey D.

Supplemental material, sj-pdf-1-jhc-10.1177_0022155420988661 for A Systems View of the Heparan Sulfate Interactome by Liliana Schaefer, Charles W. Frevert, Alejandro Gómez Toledo, James T. Sorrentino, Daniel R. Sandoval, Johan Malmström, Nathan E.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ee8cd6e0a92ebd8ab510f5742764268