Sensing the DNA-mismatch tolerance of catalytically inactive Cas9 via barcoded DNA nanostructures in solid-state nanopores.

Autor: Sandler SE; Cavendish Laboratory, University of Cambridge, Cambridge, UK., Weckman NE; Cavendish Laboratory, University of Cambridge, Cambridge, UK.; Institute for Studies in Transdisciplinary Engineering Education & Practice, Department of Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, Canada., Yorke S; Cavendish Laboratory, University of Cambridge, Cambridge, UK.; Yusuf Hamied Department of Chemistry, Cambridge, UK., Das A; Department of Pathology, University of Cambridge, Cambridge, UK.; Department of Chemical Engineering, Imperial College London, London, UK., Chen K; Cavendish Laboratory, University of Cambridge, Cambridge, UK., Gutierrez R; Oxford Nanopore Technologies, Oxford Science Park, Oxford, UK., Keyser UF; Cavendish Laboratory, University of Cambridge, Cambridge, UK. ufk20@cam.ac.uk.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 Mar; Vol. 8 (3), pp. 325-334. Date of Electronic Publication: 2023 Aug 07.

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.

Autor: Sandler SE; Cavendish Laboratory, Maxwell Centre, Department of Physics, University of Cambridge, Cambridge CB3 0HE, U.K., Horne RI; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Rocchetti S; Cavendish Laboratory, Maxwell Centre, Department of Physics, University of Cambridge, Cambridge CB3 0HE, U.K., Novak R; Cavendish Laboratory, Maxwell Centre, Department of Physics, University of Cambridge, Cambridge CB3 0HE, U.K., Hsu NS; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Castellana Cruz M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Faidon Brotzakis Z; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Gregory RC; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Chia S; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138668., Bernardes GJL; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Keyser UF; Cavendish Laboratory, Maxwell Centre, Department of Physics, University of Cambridge, Cambridge CB3 0HE, U.K., Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Nov 29; Vol. 145 (47), pp. 25776-25788. Date of Electronic Publication: 2023 Nov 16.

Multiplexed Nanopore-Based Nucleic Acid Sensing and Bacterial Identification Using DNA Dumbbell Nanoswitches.

Autor: Zhu J; Cavendish Laboratory, University of Cambridge, JJ Thompson Avenue, Cambridge CB3 0HE, U.K.; School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, No. 2, Linggong Road, Dalian 116024, China., Tivony R; Cavendish Laboratory, University of Cambridge, JJ Thompson Avenue, Cambridge CB3 0HE, U.K., Bošković F; Cavendish Laboratory, University of Cambridge, JJ Thompson Avenue, Cambridge CB3 0HE, U.K., Pereira-Dias J; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffery Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AW, U.K., Sandler SE; Cavendish Laboratory, University of Cambridge, JJ Thompson Avenue, Cambridge CB3 0HE, U.K., Baker S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffery Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AW, U.K., Keyser UF; Cavendish Laboratory, University of Cambridge, JJ Thompson Avenue, Cambridge CB3 0HE, U.K.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Jun 07; Vol. 145 (22), pp. 12115-12123. Date of Electronic Publication: 2023 May 23.

DNA-Based Optical Quantification of Ion Transport across Giant Vesicles.

Autor: Fletcher M; Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, CambridgeCB3 0HE, U.K., Zhu J; Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, CambridgeCB3 0HE, U.K., Rubio-Sánchez R; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, LondonW12 0BZ, U.K.; fabriCELL, Molecular Sciences Research Hub, Imperial College London, LondonW12 0BZ, U.K., Sandler SE; Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, CambridgeCB3 0HE, U.K., Nahas KA; Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, CambridgeCB3 0HE, U.K., Michele LD; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, LondonW12 0BZ, U.K.; fabriCELL, Molecular Sciences Research Hub, Imperial College London, LondonW12 0BZ, U.K., Keyser UF; Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, CambridgeCB3 0HE, U.K., Tivony R; Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, CambridgeCB3 0HE, U.K.

Publikováno v: ACS nano [ACS Nano] 2022 Oct 25; Vol. 16 (10), pp. 17128-17138. Date of Electronic Publication: 2022 Oct 12.

Membrane Activity of a DNA-Based Ion Channel Depends on the Stability of Its Double-Stranded Structure.

Autor: Morzy D; Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom., Joshi H; Department of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, Illinois 61801, United States., Sandler SE; Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom., Aksimentiev A; Department of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, Illinois 61801, United States.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, United States., Keyser UF; Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom.

Publikováno v: Nano letters [Nano Lett] 2021 Nov 24; Vol. 21 (22), pp. 9789-9796. Date of Electronic Publication: 2021 Nov 12.