Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sandipkumar, Darji"'
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholi
Externí odkaz:
https://doaj.org/article/435994d00b734e18a90ea82931cd1bac
Autor:
Mala V, Rao, Sandipkumar, Darji, Philip H, Stavrides, Chris N, Goulbourne, Asok, Kumar, Dun-Sheng, Yang, Lang, Yoo, James, Peddy, Ju-Hyun, Lee, Aidong, Yuan, Ralph A, Nixon
Publikováno v:
Autophagy.
How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb1de16b0b07b05b246f7b21cae68f84
https://pubmed.ncbi.nlm.nih.gov/36131358
https://pubmed.ncbi.nlm.nih.gov/36131358
Autor:
Eunju Im, Ying Jiang, Philip Stavrides, Sandipkumar Darji, Hediye Erdjument-Bromage, Thomas A. Neubert, Jun Yong Choi, Jerzy Wegiel, Ju-Hyun Lee, Ralph A. Nixon
Lysosome dysfunction arises early and propels Alzheimer’s Disease (AD). Herein, we show that amyloid precursor protein (APP), linked to early-onset AD in Down Syndrome (DS), acts directly via its β-C-terminal fragment (βCTF) to disrupt lysosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98d3efd72620e8895fb69f4ded88179
https://doi.org/10.1101/2022.06.02.494546
https://doi.org/10.1101/2022.06.02.494546
Autor:
Sandipkumar Darji, Ralph A. Nixon, Panaiyur S. Mohan, Ju-Hyun Lee, Mary Kate McBrayer, Asok Kumar, Daniel J. Colacurcio, Devin M. Wolfe, Philip Stavrides
Publikováno v:
J Mol Biol
Summary Lysosomal dysfunction is considered pathogenic in Alzheimer Disease (AD). Loss of Presenilin-1 (PSEN1) function causing AD impedes acidification via defective vATPase V0a1 subunit delivery to lysosomes. We report that isoproterenol and relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31188b33180c02023558ee740d2905c6
https://doi.org/10.1016/j.jmb.2020.02.021
https://doi.org/10.1016/j.jmb.2020.02.021
Autor:
Mala V. Rao, Sandipkumar Darji, Philip H. Stavrides, Chris N. Goulbourne, Asok Kumar, Dun-Sheng Yang, Lang Yoo, James Peddy, Ju-Hyun Lee, Aidong Yuan, Ralph A. Nixon
How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs in axons have exceptionally long half-lives in vivo enabling formation of large stable suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ad1275388ac3c7de409a872d477efd
Autor:
Eunju Im, Ying Jiang, Philip H. Stavrides, Sandipkumar Darji, Hediye Erdjument-Bromage, Neubert A. Thomas, Matteo Bordi, Jun Yong Choi, Ju-Hyun Lee, Ralph A. Nixon
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57d677b5dba222d9a3b3de403c03f60b
https://doi.org/10.2139/ssrn.4106838
https://doi.org/10.2139/ssrn.4106838
Autor:
Ursula Germann, Cynthia Bleiwas, John Alam, Dun-Sheng Yang, Balapal S. Basavarajappa, Sandeep Malampati, John Harrison, Kelly Blackburn, Afina W. Lemstra, Paul Maruff, Monika Plawik, Shivakumar Subbanna, Amanda Gardner, Niels D. Prins, Charlotte E. Teunissen, Ralph A. Nixon, Ying Jiang, John F. Smiley, Anna Pensalfini, Stephen N. Gomperts, Sandipkumar Darji, Philip Scheltens, James Peddy, Philip Stavrides
The endosome-associated protein Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long-standing target for drug development. As p38α kinase is a Rab-5 activator, we hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29c5651356ef59817c7a436ae57df45
https://doi.org/10.21203/rs.3.rs-1061364/v1
https://doi.org/10.21203/rs.3.rs-1061364/v1
Autor:
Martin J. Berg, Daniel C. Javitt, John F. Smiley, Cynthia Bleiwas, Mala V. Rao, Jean-Pierre Julien, Balapal S. Basavarajappa, Henry Sershen, Audrey Hashim, Sandipkumar Darji, Donald A. Wilson, Ralph A. Nixon, Shivakumar Subbanna, Veeranna, Aidong Yuan, David N. Guifoyle, Asok Kumar
Publikováno v:
Translational Psychiatry, Vol 8, Iss 1, Pp 1-12 (2018)
Translational Psychiatry
Translational Psychiatry
Neurofilament (NFL) proteins have recently been found to play unique roles in synapses. NFL is known to interact with the GluN1 subunit of N-methyl-d-aspartic acid (NMDAR) and be reduced in schizophrenia though functional consequences are unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dd9e3d12210628dd62e571bfb5f4af
http://link.springer.com/article/10.1038/s41398-018-0194-7
http://link.springer.com/article/10.1038/s41398-018-0194-7
Autor:
Ralph A. Nixon, Ursula Germann, John Alam, Philip Stavrides, Dun-Sheng Yang, Ying Jiang, John F. Smiley, Cynthia Bleiwas, Sandipkumar Darji
Publikováno v:
Alzheimer's & Dementia. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3904986e72a135d1dfabbd89201c70b
https://doi.org/10.1016/j.jalz.2019.09.057
https://doi.org/10.1016/j.jalz.2019.09.057
Autor:
Matteo Bordi, Sandipkumar Darji, Ying Jiang, Ralph A. Nixon, Martin J. Berg, Marian Mellén, Asok Kumar, Yutaka Sato
Publikováno v:
Cell Death & Disease
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Cell Death and Disease, Vol 10, Iss 8, Pp 1-17 (2019)
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
Cell Death and Disease, Vol 10, Iss 8, Pp 1-17 (2019)
Down syndrome (DS), a complex genetic disorder caused by chromosome 21 trisomy, is associated with mitochondrial dysfunction leading to the accumulation of damaged mitochondria. Here we report that mitophagy, a form of selective autophagy activated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cff389e6292e4a399b48fb502af4e9
https://pubmed.ncbi.nlm.nih.gov/31332166
https://pubmed.ncbi.nlm.nih.gov/31332166