Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sandip M. Swain"'
Autor:
Sandip M. Swain, Rodger A. Liddle
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this process is an inherent property of all cells
Externí odkaz:
https://doaj.org/article/9366e91fc0434b138a1356afad200300
Autor:
Nirakar Sahoo, Kefan Yang, Ina Coburger, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has b
Externí odkaz:
https://doaj.org/article/845788ec9f91486e9f2c2f0cbd2a94fb
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure. W
Externí odkaz:
https://doaj.org/article/059755caf1ba4f22bbb7543e75eea4c1
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Manipulation of the pancreas during surgery can induce acute pancreatitis due to zymogen activation. Here the authors show that the mechanoreceptor Piezo1 is activated by pressure and its activation leads to calcium dependent pancreatic injury wherea
Externí odkaz:
https://doaj.org/article/10e1a87d36af415ca7fb7de77dc16ef2
Autor:
Ahmad Farooq, Liliana Hernandez, Sandip M. Swain, Rafiq A. Shahid, Joelle M.-J. Romac, Steven R. Vigna, Rodger A. Liddle
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Proper mitochondrial function and adequate cellular ATP are necessary for normal pancreatic protein synthesis and sorting, maintenance of intracellular organelles and enzyme secretion. Inorganic phosphate is required for generating ATP and its limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca875f32dc2a88563072e4942703afb0
https://doi.org/10.1152/ajpgi.00022.2022
https://doi.org/10.1152/ajpgi.00022.2022
Autor:
Andrew B. West, Kaela Kelly, Enquan Xu, Joshua Y. Li, Arpine Sokratian, Allison Chang, Rodger A. Liddle, Shih-Hsiu Wang, Shijie Wang, John F. Ervin, Sandip M. Swain, Julia Ziaee, Nicole Bryant
Publikováno v:
Acta Neuropathol
α-Synuclein aggregation underlies pathological changes in Lewy body dementia. Recent studies highlight structural variabilities associated with α-synuclein aggregates in patient populations. Here, we develop a quantitative real-time quaking-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdee3fab4227a95ee4d5dbf934f55ee9
https://doi.org/10.1007/s00401-021-02288-1
https://doi.org/10.1007/s00401-021-02288-1
Autor:
Alisa Bernert, Sandip M. Swain, Eric Wiesel, Nirakar Sahoo, Kefan Yang, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann, Ina Coburger
Publikováno v:
Pflugers Archiv
N-type inactivation of voltage-gated K+ channels is conferred by the N-terminal “ball” domains of select pore-forming α subunits or of auxiliary β subunits, and influences electrical cellular excitability. Here, we show that hemin impairs inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3395e2b94f3cf590a86e6fb3bd6dfa8
http://europepmc.org/articles/PMC7239824
http://europepmc.org/articles/PMC7239824
Autor:
Rafiq A. Shahid, Rodger A. Liddle, Wolfgang Liedtke, Joelle Romac, Stephen J. Pandol, Steven R. Vigna, Sandip M. Swain
Publikováno v:
J Clin Invest
Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27621dac3b7fbf689c7fcdafdf17b53a
https://doi.org/10.1172/jci134111
https://doi.org/10.1172/jci134111
Autor:
Ahmad Farooq, Liliana C. Hernandez, Sandip M. Swain, Joelle Romac, Steven Vigna, Rodger A. Liddle
Publikováno v:
Gastroenterology. 162:S-910
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04fe6fd0088d761912573262198f9543
https://doi.org/10.1016/s0016-5085(22)62161-9
https://doi.org/10.1016/s0016-5085(22)62161-9
Autor:
Rodger A. Liddle, Sandip M. Swain
Although the ion channels Piezo1 and TRPV4 have been implicated in high venous pressure- and fluid shear stress-induced vascular hyperpermeability, they have been described as working independently. Moreover, the mechanism by which Piezo1 and TRPV4 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3761318b44e92589de98e67e90b178f5
https://doi.org/10.1101/2020.07.01.182212
https://doi.org/10.1101/2020.07.01.182212
