Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Sandip Kar"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010626 (2022)
Tumor necrosis factor alpha (TNFα) is a well-known modulator of apoptosis by maintaining a balance between proliferation and cell-death in normal cells. Cancer cells often evade apoptotic response following TNFα stimulation by altering signaling cr
Externí odkaz:
https://doaj.org/article/a2253fdec8ba44958b60c13e1ef4ba78
Autor:
Vinodhini Govindaraj, Sandip Kar
Publikováno v:
Computational and Systems Oncology, Vol 1, Iss 2, Pp n/a-n/a (2021)
Abstract MicroRNAs (miRNAs) often govern the cell fate decision‐making events associated with oncogenesis. miRNAs repress the target genes either by degrading the target mRNA or inhibiting the process of translation. However, mathematical and compu
Externí odkaz:
https://doaj.org/article/40252bd0c7cd4044a96156e0cab41c60
Autor:
Lorenz Adlung, Sandip Kar, Marie‐Christine Wagner, Bin She, Sajib Chakraborty, Jie Bao, Susen Lattermann, Melanie Boerries, Hauke Busch, Patrick Wuchter, Anthony D Ho, Jens Timmer, Marcel Schilling, Thomas Höfer, Ursula Klingmüller
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 1, Pp n/a-n/a (2017)
Abstract Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, is poorly understood. Here, we study d
Externí odkaz:
https://doaj.org/article/f4655425dbe749a68a27fd0cddb98e78
Autor:
Dola Sengupta, Sandip Kar
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136668 (2015)
Large gene regulatory networks (GRN) are often modeled with quasi-steady-state approximation (QSSA) to reduce the huge computational time required for intrinsic noise quantification using Gillespie stochastic simulation algorithm (SSA). However, the
Externí odkaz:
https://doaj.org/article/2072cc9d010e4110ad5cf18fb68ef00b
Publikováno v:
ACS Synthetic Biology. 11:3743-3758
Mammalian cells exhibit a high degree of intercellular variability in cell cycle period and phase durations. However, the factors orchestrating the cell cycle duration heterogeneities remain unclear. Herein, by combining cell cycle network-based math
Publikováno v:
Chemistry of Materials. 34:9892-9902
Autor:
Tagari Samanta, Sandip Kar
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b6f7a7aa0b84f9b0c86f9a35e363c73
https://doi.org/10.1007/978-1-0716-3008-2_7
https://doi.org/10.1007/978-1-0716-3008-2_7
Publikováno v:
ChemPhysChem. 24
p53 is a well-known tumor suppressor gene that acts as a transcription factor to exhibit a variety of dynamical responses by sensing different types and extent of stress conditions causing DNA damage in Mammalian cells. Mathematical modeling has play
Publikováno v:
ACS Chemical Neuroscience. 12:2360-2372
Neural stem cells (NPCs) efficiently communicate in an intercellular manner to govern specific cell fate decisions during the developmental process despite withstanding the fluctuating cellular environment. How these fluctuations from diverse origins
A generic approach to decipher the mechanistic pathway of heterogeneous protein aggregation kinetics
Publikováno v:
Chemical Science
Amyloid formation is a generic property of many protein/polypeptide chains. A broad spectrum of proteins, despite having diversity in the inherent precursor sequence and heterogeneity present in the mechanism of aggregation produces a common cross β