Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sandip Basak"'
Autor:
Nikhil Bharambe, Zhuowen Li, David Seiferth, Asha Manikkoth Balakrishna, Philip C. Biggin, Sandip Basak
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract GLIC, a proton-activated prokaryotic ligand-gated ion channel, served as a model system for understanding the eukaryotic counterparts due to their structural and functional similarities. Despite extensive studies conducted on GLIC, the molec
Externí odkaz:
https://doaj.org/article/3bd6a03aed1f435eb408bda9619f8fd6
Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs
Autor:
Arvind Kumar, Kayla Kindig, Shanlin Rao, Afroditi-Maria Zaki, Sandip Basak, Mark S. P. Sansom, Philip C. Biggin, Sudha Chakrapani
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Glycine receptors (GlyRs) mediate motor control and pain perception. Here, Kumar et al. present structures of GlyR bound to Δ9 -tetrahydrocannabinol (THC) using cryo-electron microscopy, providing insight into the therapeutic effects of cannabinoids
Externí odkaz:
https://doaj.org/article/d3b9441a73994d5ca3e63be0365623e0
Autor:
Arvind Kumar, Sandip Basak, Shanlin Rao, Yvonne Gicheru, Megan L. Mayer, Mark S. P. Sansom, Sudha Chakrapani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Glycinergic synapses play a central role in motor control and pain processing in the central nervous system. Here, authors present cryo-EM structures of the full-length glycine receptors (GlyRs) reconstituted into lipid nanodiscs in the unliganded, g
Externí odkaz:
https://doaj.org/article/dcf52f74a2044b09b3777a173af38405
Autor:
Sandip Basak, Yvonne Gicheru, Abhijeet Kapoor, Megan L. Mayer, Marta Filizola, Sudha Chakrapani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Serotonin receptors (5-HT3R) belong to the pentameric ligand-gated ion channel superfamily and mediate excitatory postsynaptic signaling. Here the authors present the high-resolution cryo-EM structure of 5-HT3AR bound with the competitive antagonist
Externí odkaz:
https://doaj.org/article/b766ed4a222d442488eb15a659c8ec8c
Autor:
Sandip Basak, Arvind Kumar, Steven Ramsey, Eric Gibbs, Abhijeet Kapoor, Marta Filizola, Sudha Chakrapani
Publikováno v:
eLife, Vol 9 (2020)
Serotonin receptors (5-HT3AR) play a crucial role in regulating gut movement, and are the principal target of setrons, a class of high-affinity competitive antagonists, used in the management of nausea and vomiting associated with radiation and chemo
Externí odkaz:
https://doaj.org/article/ff96e1ad8c044f679da8e43683623a1d
Autor:
Sandip Basak, Yvonne Gicheru, Amrita Samanta, Sudheer Kumar Molugu, Wei Huang, Maria la de Fuente, Taylor Hughes, Derek J. Taylor, Marvin T. Nieman, Vera Moiseenkova-Bell, Sudha Chakrapani
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Serotonin receptor (5-HT3AR), a pentameric ligand-gated ion channel, regulates numerous gastrointestinal functions. Here the authors provide a cryo-electron microscopic structure from the full-length 5-HT3AR in the apo-state which corresponds to a re
Externí odkaz:
https://doaj.org/article/1bb90dff34df4dafbd0d19b7edd091cb
Publikováno v:
eLife, Vol 6 (2017)
Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω−3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-in
Externí odkaz:
https://doaj.org/article/4aa95d1bf8d546ed855693c2a807034a
Autor:
Sandip Basak
Publikováno v:
SJCC Management Research Review. :29-40
When the economy of entire world has been shattered by the sudden strike of Covid-19 Pandemic, Indian economy is still running with the help of Pharmaceutical Industry. It acts as a strong backbone of the economy. According to IKON Marketing Consulta
Autor:
Sandip Basak, Soma Das
Publikováno v:
JOURNAL OF ACADEMIC ADVANCEMENT. 1:4-12
Women’s Empowerment and Internet are closely related in 21st century. Internet is a medium which enables people now days to reach maximum numbers of potential customers with less expenses and in a very short time where job is very flexible in natur
Autor:
Chui Fann Wong, Wuan-Geok Saw, Sandip Basak, Mio Sano, Hiroshi Ueno, Hwee Wen Kerk, Dennis Litty, Priya Ragunathan, Thomas Dick, Volker Müller, Hiroyuki Noji, Gerhard Grüber
Publikováno v:
Antimicrob Agents Chemother
The F1FO-ATP synthase is required for the viability of tuberculosis- (TB) and non- tuberculous mycobacteria (NTM) and has been validated as a drug-target. Here, we present the cryo-EM structures of the Mycobacterium smegmatis F1-ATPase and the F1FO-A