Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sandhya S. Nerurkar"'
Autor:
Thomas J. Tucker, Lauren L. Cline, Bradley P. Feuston, David M. Tellers, Vasant Jadhav, Robert L. Peiffer, Sandhya S. Nerurkar, Lynn A. O’Neill-Davis, Steven L. Regen, Vaclav Janout, Yu Yuan, Ann O’Brien, Lee J. Klein
Publikováno v:
Bioconjugate Chemistry
The synthesis, computer modeling, and biological activity of an octawalled molecular umbrella short interfacing RNA (siRNA) conjugate is described. This molecular umbrella-siRNA conjugate exhibited mRNA knockdown activity in vitro in the absence of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed0788df98a80639c2be2827b3f43b0
https://doi.org/10.1021/bc400506m
https://doi.org/10.1021/bc400506m
Autor:
Tian-Li Yue, Sandhya S. Nerurkar, Rosanna C. Mirabile, Alan R. Olzinski, Kendall S. Frazier, D. Rajagopalan, Robert N. Willette, S. P. O'Brien, J. Jing
Publikováno v:
Biomarkers. 12:87-112
The assessment of target organ damage is important in defining the optimal treatment of hypertension and blood pressure-related cardiovascular disease. The aims of the present study were (1) to investigate candidate biomarkers of target organ damage,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adce2c06ac195dc921e984e261d61481
https://doi.org/10.1080/13547500600944930
https://doi.org/10.1080/13547500600944930
Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells
Autor:
Douglas G. Johns, Nambi Aiyar, Stephen A. Douglas, Haisong Ju, Sandhya S. Nerurkar, Jyoti Disa, Colin H. Macphee, Zhaohui Ao, Robert N. Willette
Publikováno v:
Molecular and Cellular Biochemistry. 295:113-120
Lysophosphatidylcholine (LPC) is the major bioactive lipid component of oxidized LDL, thought to be responsible for many of the inflammatory effects of oxidized LDL described in both inflammatory and endothelial cells. Inflammation-induced transforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddbbbc3a7ff7ac8496adac4e852eb42
https://doi.org/10.1007/s11010-006-9280-x
https://doi.org/10.1007/s11010-006-9280-x
Autor:
Rogely W. Boyce, Thomas R. Schaeffer, Rosanna C. Mirabile, Robert N. Willette, Beat M. Jucker, David F. Adams, Stephen C. Lenhard, Sandhya S. Nerurkar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 307:939-946
Recent evidence suggests p38 mitogen-activated protein kinase (MAPK) signal transduction plays an important role in the pathogenesis of progressive renal disease. Using dynamic contrast enhanced magnetic resonance imaging (MRI), we evaluated chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569354372376c47442ff9818580de97b
https://doi.org/10.1124/jpet.103.057398
https://doi.org/10.1124/jpet.103.057398
Autor:
Ian W. Davies, Daniel Zewge, Vasant Jadhav, Sandhya S. Nerurkar, Denise M. Kenski, David M. Tellers, Jenny J. Li, Yu Yuan, W. Michael Flanagan, Francis Gosselin
Publikováno v:
Bioconjugate chemistry. 25(12)
Chemical modification of siRNA is achieved in a high-throughput manner (96-well plate format) by copper catalyzed azide–alkyne cycloadditions. This transformation can be performed in one synthetic operation at up to four positions with complete spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f762efb9e1c7905534c319500d2622
https://pubmed.ncbi.nlm.nih.gov/25398098
https://pubmed.ncbi.nlm.nih.gov/25398098
Autor:
Robert N. Willette, Sandhya S. Nerurkar, Cindy E. Fishman, Gregory H. Turner, Kevin S. Thorneloe, Weike Bao, Gerald Stankus, Robert W. Marquis, Tian-Li Yue, David J. Figueroa, David J. Behm, Robert E. Lee Trout, Bartholomew J. Votta, Xiaoping Xu, Anthony Sulpizio, Erin S. R. Lashinger, Heath Thomas, Chris P. Doe, Linda N. Casillas, Zuojun Lin, Irina M. Lozinskaya, Sandra J. Hoffman, Haisong Ju, Min Lin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 326(2)
The transient receptor potential (TRP) vanilloid subtype 4 (V4) is a nonselective cation channel that exhibits polymodal activation and is expressed in the endothelium, where it contributes to intracellular Ca2+ homeostasis and regulation of cell vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e1487a0206ac966ebc38fbb142f50e
https://pubmed.ncbi.nlm.nih.gov/18499744
https://pubmed.ncbi.nlm.nih.gov/18499744
Autor:
Beat M. Jucker, Weike Bao, Eliot H. Ohlstein, Tian-Li Yue, Lea Sarov-Blat, Klaudia Steplewski, Sandhya S. Nerurkar, Robert N. Willette
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 325(2)
Peroxisome proliferator-activated receptor (PPAR)-delta is a transcription factor that belongs to the PPAR family. PPAR-delta is abundantly expressed in the heart, and its role in the heart is largely unknown. We tested whether pharmacological activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6327afc7b5c8e2f77b256edfce1fcd
https://pubmed.ncbi.nlm.nih.gov/18287212
https://pubmed.ncbi.nlm.nih.gov/18287212
Autor:
Zhaohui Ao, Douglas G. Johns, Sandhya S. Nerurkar, Tina N Woods, Stephen A. Douglas, Robert N. Willette, Robert W. Coatney, Weike Bao, Rosanna C. Mirabile, Tian-Li Yue, Christopher P. Doe, Ross G. Bentley, David J. Behm, Jason F Ohlstein
Publikováno v:
Journal of cardiovascular pharmacology. 49(6)
Angiotensin II (Ang II) activates p38 mitogen-activated protein kinase (p38 MAPK) and increases reactive oxygen species (ROS), but the nature of the relationship in vivo is not fully understood. We assess the effect of SB239063AN, a highly selective,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91003321a9af305f48e9f7b216b9ee3
https://pubmed.ncbi.nlm.nih.gov/17577100
https://pubmed.ncbi.nlm.nih.gov/17577100
Autor:
Marinella Berova, Robert N. Willette, Alan R. Olzinski, Haisong Ju, John C. Lee, Rosanna C. Mirabile, Joseph Sisko, Sandhya S. Nerurkar, Charles F. Sauermelch, Dawn Zimmerman, Jerry L. Adams
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 301(1)
The vascular response to mechanical injury involves inflammatory and fibroproliferative processes that result in the formation of neointima and vascular remodeling. The complex cellular interactions initiated by vascular injury are coordinated and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca0bf83317a428af29612231960a6d7
https://pubmed.ncbi.nlm.nih.gov/11907152
https://pubmed.ncbi.nlm.nih.gov/11907152
Publikováno v:
In Vivo Models of Inflammation ISBN: 9783034877770
Since the initial descriptions in the early 1970s of methods to successfully generate recombinant DNA molecules [1, 2], recombinant DNA technology has advanced to the point that researchers now have the ability to routinely introduce DNA into the gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad08ef70943939e8279259c64cde38cd
https://doi.org/10.1007/978-3-0348-7775-6_13
https://doi.org/10.1007/978-3-0348-7775-6_13
