Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Sandhya P, Koushika"'
Autor:
Sravanthi S P Nadiminti, Shirley B Dixit, Neena Ratnakaran, Anushka Deb, Sneha Hegde, Sri Padma Priya Boyanapalli, Sierra Swords, Barth D Grant, Sandhya P Koushika
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011253 (2024)
Synaptic vesicle proteins (SVps) are transported by the motor UNC-104/KIF1A. We show that SVps travel in heterogeneous carriers in C. elegans neuronal processes, with some SVp carriers co-transporting lysosomal proteins (SV-lysosomes). LRK-1/LRRK2 an
Externí odkaz:
https://doaj.org/article/f351698fe66249449565fcdd74304d3b
Autor:
Jean-Sébastien Teoh, Amruta Vasudevan, Wenyue Wang, Samiksha Dhananjay, Gursimran Chandhok, Roger Pocock, Sandhya P. Koushika, Brent Neumann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Microtubules are fundamental elements of neuronal structure and function. They are dynamic structures formed from protofilament chains of α- and β-tubulin heterodimers. Acetylation of the lysine 40 (K40) residue of α-tubulin protects micr
Externí odkaz:
https://doaj.org/article/6d4a5a6e6cf440528d34ee231857d33f
Autor:
Kasturi Chakraborty, Palapuravan Anees, Sunaina Surana, Simona Martin, Jihad Aburas, Sandrine Moutel, Franck Perez, Sandhya P Koushika, Paschalis Kratsios, Yamuna Krishnan
Publikováno v:
eLife, Vol 10 (2021)
Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease targets that need corrective action are localized in specific organs, and thus realizing the
Externí odkaz:
https://doaj.org/article/e17f89fffdfc4f8583ce3191789eed92
Autor:
Vidur Sabharwal, Sandhya P. Koushika
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
High concentration of cytoskeletal filaments, organelles, and proteins along with the space constraints due to the axon’s narrow geometry lead inevitably to intracellular physical crowding along the axon of a neuron. Local cargo movement is essenti
Externí odkaz:
https://doaj.org/article/90c51f7ffc2945b782f7f410ee07434f
Autor:
Amruta Vasudevan, Reshma Maiya, Keertana Venkatesh, Vinod Kumar, Parul Sood, Kausalya Murthy, Sandhya P. Koushika, Gautam I. Menon
Publikováno v:
Journal of Cell Science.
Stationary clusters of vesicles are a prominent feature of axonal transport, but little is known about their physiological and functional relevance to axonal transport. We investigate the role of vesicle motility characteristics in modulating the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a127e9f7a235da0ca69f9a74d2e6425d
https://doi.org/10.1242/jcs.261223
https://doi.org/10.1242/jcs.261223
Autor:
Shruti Thapliyal, Amruta Vasudevan, Yongming Dong, Jihong Bai, Sandhya P Koushika, Kavita Babu
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007263 (2018)
The C. elegans ortholog of mammalian calsyntenins, CASY-1, is an evolutionarily conserved type-I transmembrane protein that is highly enriched in the nervous system. Mammalian calsyntenins are strongly expressed at inhibitory synapses, but their role
Externí odkaz:
https://doaj.org/article/b9911e8327184d77a4cd3f791e9312d0
Autor:
Bikash Choudhary, Madhushree Kamak, Neena Ratnakaran, Jitendra Kumar, Anjali Awasthi, Chun Li, Ken Nguyen, Kunihiro Matsumoto, Naoki Hisamoto, Sandhya P Koushika
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007100 (2017)
JIP3/UNC-16/dSYD is a MAPK-scaffolding protein with roles in protein trafficking. We show that it is present on the Golgi and is necessary for the polarized distribution of synaptic vesicle proteins (SVPs) and dendritic proteins in neurons. UNC-16 ex
Externí odkaz:
https://doaj.org/article/0b3b36cf1b74415c83b6a5fecb1c3074
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Externí odkaz:
https://doaj.org/article/e9f21f3340b6450190b0edee6f8a9cb1
Publikováno v:
Cytoskeleton. 77:97-109
Actin is a major cytoskeletal element involved in multiple cellular processes. Actin-rich regions present along the neuronal process aid in neuronal function, mediating multiple events involved in organelle trafficking. Actin is involved in organelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f96025285e719462d0009071a8b478
https://doi.org/10.1002/cm.21580
https://doi.org/10.1002/cm.21580
Publikováno v:
Journal of visualized experiments : JoVE. (182)
Caenorhabditis elegans (C. elegans) have proved to be a valuable model system for studying developmental and cell biological processes. Understanding these biological processes often requires long-term and repeated imaging of the same animal. Long re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::385929fa02131dd87fc9718e3b55ac7e
https://pubmed.ncbi.nlm.nih.gov/35467659
https://pubmed.ncbi.nlm.nih.gov/35467659