Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sandhya Chandrasekaran"'
Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions
Autor:
Sandhya Chandrasekaran, Sergio Espeso-Gil, Yong-Hwee Eddie Loh, Behnam Javidfar, Bibi Kassim, Yueyan Zhu, Yuan Zhang, Yuhao Dong, Lucy K. Bicks, Haixin Li, Prashanth Rajarajan, Cyril J. Peter, Daijing Sun, Esperanza Agullo-Pascual, Marina Iskhakova, Molly Estill, Bluma J. Lesch, Li Shen, Yan Jiang, Schahram Akbarian
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Repeat-rich sequences play a role in 3D genome architecture in higher eukaryotes; however, this remains unexplored in brain cells. Here, the authors show that upregulation of endogenous retroviral (ERV) sequences is linked to changes in the 3D struct
Externí odkaz:
https://doaj.org/article/07892eb57c2e48d7ba5aa0eeb9ce6966
Autor:
Lucy K. Bicks, Kazuhiko Yamamuro, Meghan E. Flanigan, Julia Minjung Kim, Daisuke Kato, Elizabeth K. Lucas, Hiroyuki Koike, Michelle S. Peng, Daniel M. Brady, Sandhya Chandrasekaran, Kevin J. Norman, Milo R. Smith, Roger L. Clem, Scott J. Russo, Schahram Akbarian, Hirofumi Morishita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Isolation during critical periods of development prevents development of normal social behaviours in mice, and this is thought to involve the prefrontal cortex. Here, the authors identify an activation pattern in parvalbumin-positive interneurons in
Externí odkaz:
https://doaj.org/article/e3415caf868e48819828d52e7b559a2f
Autor:
Sergio Espeso-Gil, Tobias Halene, Jaroslav Bendl, Bibi Kassim, Gabriella Ben Hutta, Marina Iskhakova, Neda Shokrian, Pavan Auluck, Behnam Javidfar, Prashanth Rajarajan, Sandhya Chandrasekaran, Cyril J. Peter, Alanna Cote, Rebecca Birnbaum, Will Liao, Tyler Borrman, Jennifer Wiseman, Aaron Bell, Michael J. Bannon, Panagiotis Roussos, John F. Crary, Zhiping Weng, Stefano Marenco, Barbara Lipska, Nadejda M. Tsankova, Laura Huckins, Yan Jiang, Schahram Akbarian
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-19 (2020)
Abstract Background Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ)
Externí odkaz:
https://doaj.org/article/12c3984af6c44601a2a73a399133c309
Autor:
Sergio Espeso-Gil, Aliaksei Z. Holik, Sarah Bonnin, Shalu Jhanwar, Sandhya Chandrasekaran, Roger Pique-Regi, Júlia Albaigès-Ràfols, Michael Maher, Jon Permanyer, Manuel Irimia, Marc R. Friedländer, Meritxell Pons-Espinal, Schahram Akbarian, Mara Dierssen, Philipp G. Maass, Charlotte N. Hor, Stephan Ossowski
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organiza
Externí odkaz:
https://doaj.org/article/3401930196b94c0bb26144c4e20bf5cc
Publikováno v:
Brain Multiphysics, Vol 2, Iss , Pp 100033- (2021)
Shear shocks, which exist in a completely different regime from compressional shocks, were recently observed in the brain. These low phase speed (≈ 2 m/s) high Mach number (≈ 1) waves could be the primary mechanism behind diffuse axonal injury du
Externí odkaz:
https://doaj.org/article/d46bc2ad068e43c4bbe7db1536e1645d
Autor:
Amara L. Plaza-Jennings, Aditi Valada, Callan O’Shea, Marina Iskhakova, Benxia Hu, Behnam Javidfar, Gabriella Ben Hutta, Tova Lambert, Jacinta Murray, Bibi Kassim, Sandhya Chandrasekaran, Benjamin K. Chen, Susan Morgello, Hyejung Won, Schahram Akbarian
Exploration of genome organization and function in the HIV infected brain is critical to aid in the development of treatments for HIV-associated neurocognitive disorder (HAND) and HIV cure strategies. Here, we generated a resource comprised of single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951c258e98aa06902039f4ede424e5ad
https://doi.org/10.1101/2022.05.03.490485
https://doi.org/10.1101/2022.05.03.490485
Autor:
Yan Jiang, Tyler M. Borrman, Jennifer Wiseman, Gabriella Hutta, Tobias B. Halene, Cyril J. Peter, Nadejda M. Tsankova, Pavan Auluck, John F. Crary, Sergio Espeso-Gil, Neda Shokrian, Jaroslav Bendl, Behnam Javidfar, Alanna C. Cote, Sandhya Chandrasekaran, Schahram Akbarian, Stefano Marenco, Michael J. Bannon, Panagiotis Roussos, Aaron J Bell, Rebecca Birnbaum, Bibi Kassim, Barbara K. Lipska, Prashanth Rajarajan, Laura M. Huckins, Will Liao, Marina Iskhakova, Zhiping Weng
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-19 (2020)
Genome Medicine
Genome Medicine
Background Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a sever
Autor:
Kazuhiko Yamamuro, Elizabeth K. Lucas, Sandhya Chandrasekaran, Roger L. Clem, Lucy K. Bicks, Scott J. Russo, Daisuke Kato, Milo R. Smith, Schahram Akbarian, Michelle S. Peng, Hirofumi Morishita, Kevin J. Norman, Daniel M. Brady, Hiroyuki Koike, Julia Minjung Kim, Meghan E. Flanigan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Social isolation during the juvenile critical window is detrimental to proper functioning of the prefrontal cortex (PFC) and establishment of appropriate adult social behaviors. However, the specific circuits that undergo social experience-dependent
Autor:
Tyler M. Borrman, Will Liao, Sandhya Chandrasekaran, Zhiping Weng, Schahram Akbarian, Yan Jiang, Prashanth Rajarajan, Sergio Espeso-Gil, Kristen J. Brennand
Publikováno v:
Curr Opin Neurobiol
The ‘non-linear’ genome, or the spatial proximity of non-contiguous sequences, emerges as an important regulatory layer for genome organization and function, including transcriptional regulation. Here, we review recent genome-scale chromosome con
NEURON-SPECIFIC CHROMOSOMAL MEGADOMAIN ORGANIZATION IS ADAPTIVE TO RECENT RETROTRANSPOSON EXPANSIONS
Autor:
Yan Jiang, Li Shen, Lucy K. Bicks, Cyril J. Peter, Yong-Hwee E. Loh, Yueyan Zhu, Sandhya Chandrasekaran, Esperanza Agulló-Pascual, Behnam Javidfar, Schahram Akbarian, Sergio Espeso-Gil, Prashanth Rajarajan, Marina Iskhakova, Bibi Kassim, Yuhao Dong, Molly Estill
Here, we mapped cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic ‘B2NeuN+’ megabase-scaling subc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca0281ae83a6441d4f5476f0705a76ed
https://doi.org/10.1101/2021.08.30.458289
https://doi.org/10.1101/2021.08.30.458289