122 Quantification of tumor infiltrating lymphocytes (TILs) from pathology slides reflects molecular immune phenotypes

Autor: Michael Griffin, Sandhya Srinivasan, Jake Conway, Benjamin Glass, Fedaa Najdawi, Ciyue Shen, Shima Nofallah, Chintan Parmar, Michael G Drage, Darpan T Sanghavi, Limin Yu, Raymond Biju, Daniel Borders, Matthew Bronnimann, Laura Chambre, Issac Finberg, Jonathan Glickman, Sidharth Gupta, Natalia Harguindeguy, Nhat Le, Stephanie Hennek, Syed Ashar Javed, Christian Kirkup, Miles Markey, Michael Nercessian, Daniel Shenker, Vignesh Valaboju, Samuel AV Mercedes, Bahar Rahsepar, Ryan Leung, Archit Khosla, Amaro Taylor-Weiner, Ylaine Gerardin, John Abel

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/f3f11b9b5b2b4183b35fd446b2be9291

LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

Autor: Prabhjot Kaur, Marvin Rausch, Basanti Malakar, Uchenna Watson, Nikhil P. Damle, Yogesh Chawla, Sandhya Srinivasan, Kanika Sharma, Tanja Schneider, Gagan Deep Jhingan, Deepak Saini, Debasisa Mohanty, Fabian Grein, Vinay Kumar Nandicoori

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a h

Externí odkaz: https://doaj.org/article/229dcd6f9fca48209698162286590a15

Mycobacterium tuberculosis Reactivates HIV-1 via Exosome-Mediated Resetting of Cellular Redox Potential and Bioenergetics

Autor: Priyanka Tyagi, Virender Kumar Pal, Ragini Agrawal, Shalini Singh, Sandhya Srinivasan, Amit Singh

Publikováno v: mBio, Vol 11, Iss 2 (2020)

ABSTRACT The synergy between Mycobacterium tuberculosis and human immunodeficiency virus-1 (HIV-1) interferes with therapy and facilitates the pathogenesis of both human pathogens. Fundamental mechanisms by which M. tuberculosis exacerbates HIV-1 inf

Externí odkaz: https://doaj.org/article/bb6c30229a30454a9ed868b2b816b07d

Authorship controversies in academic publication: implications for science and the research environment

Autor: Trudo, Lemmens, Sandhya, Srinivasan

Publikováno v: Indian Journal of Medical Ethics. 7:179-183

The inspiration for this theme issue came from one of the biggest challenges that the journal has faced since its inception.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422208042b193b0f7a24638f9573305e
https://doi.org/10.20529/ijme.2022.051

A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations

Autor: Ranjay, Jayadev, Mychel R P T, Morais, Jamie M, Ellingford, Sandhya, Srinivasan, Richard W, Naylor, Craig, Lawless, Anna S, Li, Jack F, Ingham, Eric, Hastie, Qiuyi, Chi, Maryline, Fresquet, Nikki-Maria, Koudis, Huw B, Thomas, Raymond T, O'Keefe, Emily, Williams, Antony, Adamson, Helen M, Stuart, Siddharth, Banka, Damian, Smedley, David R, Sherwood, Rachel, Lennon

Publikováno v: Genomics England Research Consortium 2022, ' A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations ', Science Advances, vol. 8, no. 20, eabn2265 . https://doi.org/10.1126/sciadv.abn2265

Basement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of 222 human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d51eaf7f96020b423d4c6daee051185
https://doi.org/10.1126/sciadv.abn2265