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of 23
pro vyhledávání: '"Sandholu A"'
Autor:
Jun Wang, Georgy Chistov, Junrui Zhang, Brandon Huntington, Israa Salem, Anandsukeerthi Sandholu, Stefan T. Arold
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34487- (2024)
Targeted protein degradation (TPD) allows cells to maintain a functional proteome and to rapidly adapt to changing conditions. Methods that repurpose TPD for the deactivation of specific proteins have demonstrated significant potential in therapeutic
Externí odkaz:
https://doaj.org/article/d4e4bb07a8a54110afad496c7310d683
Autor:
Wang, Jun, Chistov, Georgy, Zhang, Junrui, Huntington, Brandon, Salem, Israa, Sandholu, Anandsukeerthi, Arold, Stefan T.
Publikováno v:
In Heliyon 30 July 2024 10(14)
Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily
Publikováno v:
In iScience 21 July 2023 26(7)
Akademický článek
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Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107031- (2023)
Summary: The Ras superfamily of GTPases regulate critical cellular processes by shuttling between GTP-bound ON and GDP-bound OFF states. This switching mechanism is attributed to the conformational changes in two loops, SWI and SWII, upon GTP binding
Externí odkaz:
https://doaj.org/article/422df69e8ea94c1194bb2aed13f9877b
Ras superfamily GTPases are molecular switches which regulate critical cellular processes. Extensive structural and computational studies on this G protein family have tried to establish a general framework for their switching mechanism. The current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d90c732dc7a3b9ceec0a2cc39c7d9f5
https://doi.org/10.1101/2020.08.15.252247
https://doi.org/10.1101/2020.08.15.252247
Autor:
null Anand S. Sandholu, null Sharmila P. Mujawar, null Ramakrishnan Krithika, null Hirekodathakallu V. Thulasiram, null Kiran Kulkarni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d9bba56343d93ab5970828acfeda3a
https://doi.org/10.1002/prot.25891/v3/response1
https://doi.org/10.1002/prot.25891/v3/response1
Publikováno v:
SSRN Electronic Journal.
Ras superfamily of small GTPases are molecular switches which regulate critical cellular processes. Three decades of structural and computational studies on this G protein family have tried to establish a general framework on their switching mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ec78ddff3e72bfda501c06ff68e353f
https://doi.org/10.2139/ssrn.3569560
https://doi.org/10.2139/ssrn.3569560
Autor:
Durba Sengupta, Kiran Kulkarni, William L. Duax, Madhura Mohole, Hirekodathakallu V. Thulasiram, Anand S. Sandholu
Publikováno v:
FEBS Letters. 592:2624-2635
Iridoid synthases belong to the family of short-chain dehydrogenase/reductase involved in the biosynthesis of iridoids. Despite having high sequence and structural homology with progesterone 5β-reductase, these enzymes exhibit differential substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865966f0355557401f1af852608e90f1
https://doi.org/10.1002/1873-3468.13174
https://doi.org/10.1002/1873-3468.13174