Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sandesh Chopade"'
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study
Autor:
Diana Dunca, Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan, Amand F. Schmidt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C
Externí odkaz:
https://doaj.org/article/23e5af9de5984d279421ac7ebb2dc74e
Autor:
A. Floriaan Schmidt, Chris Finan, Sandesh Chopade, Stephan Ellmerich, Martin N. Rossor, Aroon D. Hingorani, Mark B. Pepys
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein, which is cytotoxic for cerebral neurones and al
Externí odkaz:
https://doaj.org/article/7b7fa5020a354c8684a1fb1ebee1aca7
Autor:
María Gordillo-Marañón, Magdalena Zwierzyna, Pimphen Charoen, Fotios Drenos, Sandesh Chopade, Tina Shah, Jorgen Engmann, Nishi Chaturvedi, Olia Papacosta, Goya Wannamethee, Andrew Wong, Reecha Sofat, Mika Kivimaki, Jackie F. Price, Alun D. Hughes, Tom R. Gaunt, Deborah A. Lawlor, Anna Gaulton, Aroon D. Hingorani, Amand F. Schmidt, Chris Finan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Drug target Mendelian randomization (MR) uses genetic variation in or near a gene encoding a drug target to anticipate the effect of drug action on the same target. Using drug target MR, the authors prioritized 30 targets that might elicit beneficial
Externí odkaz:
https://doaj.org/article/da0636481f784c5bbf9d63d052cf0333
Autor:
Amand F. Schmidt, Chris Finan, Maria Gordillo-Marañón, Folkert W. Asselbergs, Daniel F. Freitag, Riyaz S. Patel, Benoît Tyl, Sandesh Chopade, Rupert Faraway, Magdalena Zwierzyna, Aroon D. Hingorani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.
Externí odkaz:
https://doaj.org/article/314860a99a3044359893ed3a7d40aa29
Autor:
Amand F. Schmidt, Mimount Bourfiss, Abdulrahman Alasiri, Esther Puyol-Anton, Sandesh Chopade, Marion van Vugt, Sander W. van der Laan, Christian Gross, Chris Clarkson, Albert Henry, Tom R. Lumbers, Pim van der Harst, Nora Franceschini, Joshua C. Bis, Birgitta K. Velthuis, Anneline S. J. M. te Riele, Aroon D. Hingorani, Bram Ruijsink, Folkert W. Asselbergs, Jessica van Setten, Chris Finan
Publikováno v:
Science Advances. 9
Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular
Autor:
Valerie Kuan, Spiros Denaxas, Praveetha Patalay, Dorothea Nitsch, Rohini Mathur, Arturo Gonzalez-Izquierdo, Reecha Sofat, Linda Partridge, Amanda Roberts, Ian C K Wong, Melanie Hingorani, Nishi Chaturvedi, Harry Hemingway, Aroon D Hingorani, Daniel C Alexander, Innocent G Asiimwe, Simon Ball, Frances Bennett, Maria Carolina Borges, Adam Butterworth, Sandesh Chopade, Christopher Clarkson, Martin Cox, Caroline Dale, Diana Dunca, Jorgen E Engmann, Alba Fernandez-Sanles, Chris Finan, Natalie Fitzpatrick, Jean Gallagher, Jasmine Gratton, Christian Gross, Albert Henry, Mira Hidajat, Aroon Hingorani, Nikita Hukerikar, Andrea Jorgensen, Roshni Joshi, Michail Katsoulis, Rashmi Kumar, Alvina G Lai, Claudia Langenberg, Deborah Lawlor, Mary Mancini, Diane Miller, Margaret Ogden, Eda B Ozyigit, Shilpa Patel, Munir Pirmohamed, David Ryan, Amand F Schmidt, Anoop D Shah, Tina Shah, Rohan Takhar, Ana Torralbo, Ayath Ullah, Lauren E Walker, Alasdair Warwick, Eleanor Wheeler, Victoria L Wright, Honghan Wu, Magdalena Zwierzyna
Publikováno v:
Lancet Digit Health
BACKGROUND: Globally, there is a paucity of multimorbidity and comorbidity data, especially for minority ethnic groups and younger people. We estimated the frequency of common disease combinations and identified non-random disease associations for al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7846da2bd254f898cdef909442be297
https://hdl.handle.net/21.11116/0000-000B-B70D-9
https://hdl.handle.net/21.11116/0000-000B-B70D-9
Autor:
Mona M. Almramhi, Chris Finan, Catherine S. Storm, Amand F. Schmidt, Demis A. Kia, Rachel Coneys, Sandesh Chopade, Aroon D. Hingorani, Nicholas W. Wood
BackgroundThere has been considerable interest in statins due to their pleiotropic effects beyond their lipid-lowering properties. Many of these pleiotropic effects are predominantly ascribed to their capacity to inhibit the isoprenylation of Rho sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2451e63830e2b3140e0c07d475a2b19b
https://doi.org/10.1101/2022.08.01.22277781
https://doi.org/10.1101/2022.08.01.22277781
Autor:
John P. Overington, Spiros Denaxas, David Prieto, Felix A. Kruger, Raymond J. MacAllister, Aroon D. Hingorani, Harry Hemingway, Anna Gaulton, Reecha Sofat, Valerie Kuan, Sandesh Chopade, Juan P Casas, Chris Finan
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-25 (2019)
Scientific Reports
Scientific Reports
Lack of efficacy in the intended disease indication is the major cause of clinical phase drug development failure. Explanations could include the poor external validity of pre-clinical (cell, tissue, and animal) models of human disease and the high f
Autor:
Ingrid Wise, Bradley Godfrey, Raymond T. O'Keefe, Mikael Ekholm, Wojciech Wystrychowski, Pasquale Maffia, Matthias Kretzler, Sushant Saluja, James Eales, Artur Akbarov, Christopher Finan, Maciej Tomaszewski, Monika Szulińska, Gosia Trynka, Matthew Denniff, Sanjeev Pramanik, Ewa Zukowska-Szczechowska, Bernard Keavney, Andrew P. Morris, Yusif Shakanti, Sandesh Chopade, John Bowes, Eddie Cano-Gamez, Huw B. Thomas, Matthew G. Sampson, Xiaoguang Xu, Evangelos Evangelou, Paweł Bogdański, Priscilla R. Prestes, Stephen Eyre, Xiao Jiang, David Talavera, Fadi J. Charchar, Hui Guo, Andrzej Antczak, Joanna Zywiec, Nilesh J. Samani, Alicja Nazgiewicz, Michelle T. McNulty, Adrian S. Woolf, Robert Król, Tomasz J. Guzik, Jason Brown, Carlo Berzuini, Mahan Salehi, Maciej Glyda, Aroon D. Hingorani, Felix Eichinger, Mark J. Caulfield
Publikováno v:
Nature Genetics
Eales, J, Jiang, X, Xu, X, Saluja, S, Akbarov, A, Cano-Gomez, E, McNulty, M T, Finan, C, Guo, H, Wystrychowski, W, Szulinska, M, Thomas, H, Pramanik, S, Chopade, S, Prestes, P R, Wise, I, Evangelou, E, Salehi, M, Shakanti, Y, Ekholm, M, Denniff, M, Nazgiewicz, A, Eichinger, F, Godfrey, B, Antczak, A, Glyda, M, Król, R, Eyre, S, Brown, J, Berzuini, C, Bowes, J, Caulfield, M, Zukowska-Szczechowska, E, Zywiec, J, Bogdanski, P, Kretzler, M, Woolf, A S, Talavera, D, Keavney, B, Maffia, P, Guzik, T J, O'Keefe, R, Trynka, G, Samani, N J, Hingorani, A D, Sampson, M G, Morris, A P, Charchar, F J, Tomaszewski, M & Morris, A 2021, ' Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney ', Nature Genetics, vol. 53, no. 5, pp. 630–637 . https://doi.org/10.1038/s41588-021-00835-w
Eales, J, Jiang, X, Xu, X, Saluja, S, Akbarov, A, Cano-Gomez, E, McNulty, M T, Finan, C, Guo, H, Wystrychowski, W, Szulinska, M, Thomas, H, Pramanik, S, Chopade, S, Prestes, P R, Wise, I, Evangelou, E, Salehi, M, Shakanti, Y, Ekholm, M, Denniff, M, Nazgiewicz, A, Eichinger, F, Godfrey, B, Antczak, A, Glyda, M, Król, R, Eyre, S, Brown, J, Berzuini, C, Bowes, J, Caulfield, M, Zukowska-Szczechowska, E, Zywiec, J, Bogdanski, P, Kretzler, M, Woolf, A S, Talavera, D, Keavney, B, Maffia, P, Guzik, T J, O'Keefe, R, Trynka, G, Samani, N J, Hingorani, A D, Sampson, M G, Morris, A P, Charchar, F J, Tomaszewski, M & Morris, A 2021, ' Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney ', Nature Genetics, vol. 53, no. 5, pp. 630–637 . https://doi.org/10.1038/s41588-021-00835-w
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and antihypertensive treatment. However, genetically mediated renal mechanisms underlying susceptibility to hypertension remain poorly understood. We integrated g
Autor:
Jackie F. Price, Pimphen Charoen, Reecha Sofat, Nishi Chaturvedi, Amand F. Schmidt, Sandesh Chopade, Tina Shah, Jorgen Engmann, María Gordillo-Marañón, Tom R. Gaunt, Mika Kivimäki, Alun D. Hughes, Aroon D. Hingorani, Debbie A Lawlor, Goya Wannamethee, Magdalena Zwierzyna, Chris Finan, Olia Papacosta, Andrew Wong, Anna Gaulton, Fotios Drenos
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Gordillo-Maranon, M, Zwierzyna, M, Charoen, P, Drenos, F, Chopade, S, Shah, T, Engmann, J, Chaturvedi, N, Papacosta, O, Wannamethee, G, Wong, A, Sofat, R, Kivimaki, M, Price, J F, Hughes, A D, Gaunt, T R, Lawlor, D A, Gaulton, A, Hingorani, A D, Schmidt, A F & Finan, C 2021, ' Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics ', Nature Communications . https://doi.org/10.1038/s41467-021-25731-z
Gordillo-Marañón, M, Gaunt, T R & Lawlor, D A 2021, ' Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics ', Nature Communications, vol. 12, no. 1, 6120 . https://doi.org/10.1038/s41467-021-25731-z
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Gordillo-Maranon, M, Zwierzyna, M, Charoen, P, Drenos, F, Chopade, S, Shah, T, Engmann, J, Chaturvedi, N, Papacosta, O, Wannamethee, G, Wong, A, Sofat, R, Kivimaki, M, Price, J F, Hughes, A D, Gaunt, T R, Lawlor, D A, Gaulton, A, Hingorani, A D, Schmidt, A F & Finan, C 2021, ' Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics ', Nature Communications . https://doi.org/10.1038/s41467-021-25731-z
Gordillo-Marañón, M, Gaunt, T R & Lawlor, D A 2021, ' Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics ', Nature Communications, vol. 12, no. 1, 6120 . https://doi.org/10.1038/s41467-021-25731-z
Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target’s expression or function, as a tool to anticipate the effect of drug action on the same target. Here we apply