The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model

Autor: Sander van Riet, Anais Julien, Andrea Atanasov, Åsa Nordling, Magnus Ingelman-Sundberg

Publikováno v: Hepatology Communications, Vol 8, Iss 3 (2024)

Background:. The prevalence of NAFLD is rapidly increasing. NAFLD can progress to NASH, fibrosis, cirrhosis, and HCC, which will soon become the main causes of liver transplantation. To date, no effective drug for NASH has been approved by the Food a

Externí odkaz: https://doaj.org/article/be4d1e9a688741de89e4b9650a5f9230

Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages

Autor: Sander van Riet, Annemarie van Schadewijk, Steve de Vos, Nick Vandeghinste, Robbert J. Rottier, Jan Stolk, Pieter S. Hiemstra, Padmini Khedoe

Publikováno v: Journal of Innate Immunity, Pp 1-12 (2020)

Airway epithelial cells and macrophages participate in inflammatory responses to external noxious stimuli, which can cause epithelial injury. Upon injury, epithelial cells and macrophages act in concert to ensure rapid restoration of epithelial integ

Externí odkaz: https://doaj.org/article/d6a02cae55ed470d9e44ff7ad5f29500

Development of an In Vitro Airway Epithelial–Endothelial Cell Culture Model on a Flexible Porous Poly(Trimethylene Carbonate) Membrane Based on Calu-3 Airway Epithelial Cells and Lung Microvascular Endothelial Cells

Autor: Thijs Pasman, Danielle Baptista, Sander van Riet, Roman K. Truckenmüller, Pieter S. Hiemstra, Robbert J. Rottier, Naomi M. Hamelmann, Jos M. J. Paulusse, Dimitrios Stamatialis, André A. Poot

Publikováno v: Membranes, Vol 11, Iss 3, p 197 (2021)

Due to the continuing high impact of lung diseases on society and the emergence of new respiratory viruses, such as SARS-CoV-2, there is a great need for in vitro lung models that more accurately recapitulate the in vivo situation than current models

Externí odkaz: https://doaj.org/article/84bb952fc138455997c9dab90ca154aa

3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes

Autor: Danielle Baptista, Liliana Moreira Teixeira, David Barata, Zeinab Tahmasebi Birgani, Jasia King, Sander van Riet, Thijs Pasman, André A. Poot, Dimitrios Stamatialis, Robbert J. Rottier, Pieter S. Hiemstra, Aurélie Carlier, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Roman Truckenmüller

Publikováno v: ACS Biomaterials Science and Engineering, 8(6), 2684-2699. AMER CHEMICAL SOC
ACS Biomaterials Science and Engineering, 8(6), 2684-2699. American Chemical Society
ACS Biomaterial Science and Engineering, 8(6), 2684-2699. American Chemical Society

A comparatively straightforward approach to accomplish more physiological realism in organ-on-a-chip (OoC) models is through substrate geometry. There is increasing evidence that the strongly, microscale curved surfaces that epithelial or endothelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff600ff704c9acf587e39629f23ebd9b
https://doi.org/10.1021/acsbiomaterials.1c01463

Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages

Autor: Pieter S. Hiemstra, Nick Vandeghinste, Annemarie van Schadewijk, P. Padmini S.J. Khedoe, Jan Stolk, Robbert J. Rottier, Steve De Vos, Sander van Riet

Publikováno v: Journal of Innate Immunity, 12(5), 410-421. Karger
J Innate Immun
Journal of Innate Immunity, 12(5), 410-421. KARGER
Journal of Innate Immunity, Pp 1-12 (2020)

Airway epithelial cells and macrophages participate in inflammatory responses to external noxious stimuli, which can cause epithelial injury. Upon injury, epithelial cells and macrophages act in concert to ensure rapid restoration of epithelial integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04deacab7ac366d424703ac5703f193
https://pure.eur.nl/en/publications/3187b45d-1f6a-4ccc-8d41-7cde9a69e669