Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Sander R van Hooff"'
Autor:
Evelyn Fessler, Jarno Drost, Sander R van Hooff, Janneke F Linnekamp, Xin Wang, Marnix Jansen, Felipe De Sousa E Melo, Pramudita R Prasetyanti, Joep EG IJspeert, Marek Franitza, Peter Nürnberg, Carel JM van Noesel, Evelien Dekker, Louis Vermeulen, Hans Clevers, Jan Paul Medema
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 7, Pp 745-760 (2016)
Abstract The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a determining factor in the efficacy of adjuvant therapy for individual patients. Based on gene expression profiling, CRC is currently classifie
Externí odkaz:
https://doaj.org/article/3c125446027246d588dc3339850f18d5
Autor:
Nikol Snoeren, Sander R van Hooff, Rene Adam, Richard van Hillegersberg, Emile E Voest, Catherine Guettier, Paul J van Diest, Maarten W Nijkamp, Mariel O Brok, Dik van Leenen, Marian J A Groot Koerkamp, Frank C P Holstege, Inne H M Borel Rinkes
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49442 (2012)
BACKGROUND AND OBJECTIVES: This study was designed to identify and validate gene signatures that can predict disease free survival (DFS) in patients undergoing a radical resection for their colorectal liver metastases (CRLM). METHODS: Tumor gene expr
Externí odkaz:
https://doaj.org/article/1a10b57f5c3045fc984d1e4d6c0e4aff
Autor:
Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, Xiaochen Long, Tsz-Kwong Man, Hua-Sheng Chiu, Elad Chomsky, Evgeny Kiner, Michael J. Krueger, Diego di Bernardo, Luis Voloch, Jan Molenaar, Sander R. van Hooff, Frank Westermann, Selina Jansky, Michele L. Redell, Pieter Mestdagh, Pavel Sumazin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues and reveal cells that
Externí odkaz:
https://doaj.org/article/d4626884e3864b748b5d6fb020d26428
Autor:
Kaylee M. Keller, Joost Koetsier, Linda Schild, Vicky Amo-Addae, Selma Eising, Kim van den Handel, Kimberley Ober, Bianca Koopmans, Anke Essing, Marlinde L. van den Boogaard, Karin P. S. Langenberg, Natalie Jäger, Marcel Kool, Stefan Pfister, M. Emmy M. Dolman, Jan J. Molenaar, Sander R. van Hooff
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Pediatric cancer is the leading cause of disease-related death in children and the need for better therapeutic options remains urgent. Due to the limited number of patients, target and drug development for pediatrics is often supp
Externí odkaz:
https://doaj.org/article/89c1cc504cdf4e7d978144628845f2f7
Autor:
Kaylee M. Keller, Thomas F. Eleveld, Linda Schild, Kim van den Handel, Marlinde van den Boogaard, Vicky Amo-Addae, Selma Eising, Kimberley Ober, Bianca Koopmans, Leendert Looijenga, Godelieve A.M. Tytgat, Bauke Ylstra, Jan J. Molenaar, M. Emmy M. Dolman, Sander R. van Hooff
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Neuroblastoma is the most common extracranial solid tumor found in children and despite intense multi-modal therapeutic approaches, low overall survival rates of high-risk patients persist. Tumors with heterozygous loss of chromosome 11q and MYCN amp
Externí odkaz:
https://doaj.org/article/2046bd60d71d42bd8c11809b13f2595a
Autor:
Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109568- (2021)
Summary: Malignant rhabdoid tumors (MRTs) represent one of the most aggressive childhood malignancies. No effective treatment options are available, and prognosis is, therefore, dismal. Previous studies have demonstrated that tumor organoids capture
Externí odkaz:
https://doaj.org/article/eef617a8ce4f4b48b63cff193a540d1d
Autor:
Michael I. D'Angelica, William R. Jarnagin, Ronald P. DeMatteo, Peter J. Allen, T. Peter Kingham, René Adam, Inne H.M. Borel Rinkes, Sander R. van Hooff, Nikol Snoeren, Agnes Viale, Jinru Shia, Simon Turcotte, Hiromichi Ito, Mithat Gönen, Arshi Arora, Vinod P. Balachandran
A. Overall survival in derivation (MSKCC) and validation (European) cohorts. B. Recurrence free survival in derivation (MSKCC) and validation (European) cohorts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110a81985c0ae3a445b59c0b52834109
https://doi.org/10.1158/1078-0432.22457163
https://doi.org/10.1158/1078-0432.22457163
Autor:
Michael I. D'Angelica, William R. Jarnagin, Ronald P. DeMatteo, Peter J. Allen, T. Peter Kingham, René Adam, Inne H.M. Borel Rinkes, Sander R. van Hooff, Nikol Snoeren, Agnes Viale, Jinru Shia, Simon Turcotte, Hiromichi Ito, Mithat Gönen, Arshi Arora, Vinod P. Balachandran
mRNA expression and hierarchical clustering of molecular risk score (MRS) genes in colorectal liver metastases in derivation cohort. Genes are indicated on the x-axis, patients on the y-axis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310342a793d8fc187cf9890dd347c5de
https://doi.org/10.1158/1078-0432.22457160
https://doi.org/10.1158/1078-0432.22457160
Autor:
Michael I. D'Angelica, William R. Jarnagin, Ronald P. DeMatteo, Peter J. Allen, T. Peter Kingham, René Adam, Inne H.M. Borel Rinkes, Sander R. van Hooff, Nikol Snoeren, Agnes Viale, Jinru Shia, Simon Turcotte, Hiromichi Ito, Mithat Gönen, Arshi Arora, Vinod P. Balachandran
Purpose: Risk stratification after surgery for colorectal cancer liver metastases (CRLM) is achieved using clinicopathologic variables, however, is of limited accuracy. We sought to derive and externally validate a multigene expression assay prognost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfa33480d45669d3a87d6e1d9dc3553
https://doi.org/10.1158/1078-0432.c.6523518
https://doi.org/10.1158/1078-0432.c.6523518
Autor:
Michael I. D'Angelica, William R. Jarnagin, Ronald P. DeMatteo, Peter J. Allen, T. Peter Kingham, René Adam, Inne H.M. Borel Rinkes, Sander R. van Hooff, Nikol Snoeren, Agnes Viale, Jinru Shia, Simon Turcotte, Hiromichi Ito, Mithat Gönen, Arshi Arora, Vinod P. Balachandran
Univariate and multivariate analyses of recurrence free survival in derivation (Table 1) and validation (Table 2) cohorts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d344b3037477d38a346fd0ca86a2d1
https://doi.org/10.1158/1078-0432.22457157
https://doi.org/10.1158/1078-0432.22457157