Dynamics and prognostic value of serum neurofilament light chain in Guillain-Barré syndromeResearch in context

Autor: Sander J. van Tilburg, Charlotte E. Teunissen, Carolien C.H.M. Maas, Robin C.M. Thomma, Christa Walgaard, Hans Heijst, Ruth Huizinga, Pieter A. van Doorn, Bart C. Jacobs

Publikováno v: EBioMedicine, Vol 102, Iss , Pp 105072- (2024)

Summary: Background: Neurofilament light chain (NfL) is a biomarker for axonal damage in several neurological disorders. We studied the longitudinal changes in serum NfL in patients with Guillain-Barré syndrome (GBS) in relation to disease severity,

Externí odkaz: https://doaj.org/article/beecc3ad1a104468a4575f5c12ed9042

Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: Results from an explorative study

Autor: Mohamed Javad Wahadat, Sander J van Tilburg, Yvonne M Mueller, Harm de Wit, Cornelia G Van Helden-Meeuwsen, Anton W Langerak, Marike J Gruijters, Amani Mubarak, Marleen Verkaaik, Peter D Katsikis, Marjan A Versnel, Sylvia Kamphuis

Publikováno v: Lupus Science and Medicine, 10(1):e000799. BMJ Publishing Group

ObjectiveTo combine targeted transcriptomic and proteomic data in an unsupervised hierarchical clustering method to stratify patients with childhood-onset SLE (cSLE) into similar biological phenotypes, and study the immunological cellular landscape t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195d94fd5b16161739faf0d9aec3deed
https://pure.eur.nl/en/publications/d060df1a-5129-449d-a1c9-57af7705d246

Gene signature fingerprints stratify SLE patients in groups with similar biological disease profiles: a multicentre longitudinal study

Autor: M Javad Wahadat, Dieneke Schonenberg-Meinema, Cornelia G van Helden-Meeuwsen, Sander J van Tilburg, Noortje Groot, Ellen J H Schatorjé, Esther P A H Hoppenreijs, Petra C E Hissink Muller, Danielle M C Brinkman, Denis Dvorak, Marleen Verkaaik, J Merlijn van den Berg, Kateřina Bouchalova, Sylvia Kamphuis, Marjan A Versnel

Publikováno v: Rheumatology (Oxford, England), 61(11), 4344-4354. Oxford University Press
Rheumatology, 61, 11, pp. 4344-4354
Rheumatology, 61(11), 4344-4354. OXFORD UNIV PRESS
Rheumatology, 61, 4344-4354

Objectives Clinical phenotyping and predicting treatment responses in SLE patients is challenging. Extensive blood transcriptional profiling has identified various gene modules that are promising for stratification of SLE patients. We aimed to transl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d9c34f4a25691cef9c1fe747ffb6cf
https://hdl.handle.net/1887/3575935