Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Sander I van Kasteren"'
Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner.
Autor:
Christine Burkard, Monique H Verheije, Oliver Wicht, Sander I van Kasteren, Frank J van Kuppeveld, Bart L Haagmans, Lucas Pelkmans, Peter J M Rottier, Berend Jan Bosch, Cornelis A M de Haan
Publikováno v:
PLoS Pathogens, Vol 10, Iss 11, p e1004502 (2014)
Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane, many viruses are endocytosed prior to fusion. Specific cues in the endosomal microenvironm
Externí odkaz:
https://doaj.org/article/1d8f17335c7942ac9824e89e4be9d62e
Autor:
Pekka Kujala, Claudine R Raymond, Martijn Romeijn, Susan F Godsave, Sander I van Kasteren, Holger Wille, Stanley B Prusiner, Neil A Mabbott, Peter J Peters
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002449 (2011)
After oral exposure, prions are thought to enter Peyer's patches via M cells and accumulate first upon follicular dendritic cells (FDCs) before spreading to the nervous system. How prions are actually initially acquired from the gut lumen is not know
Externí odkaz:
https://doaj.org/article/bb3de0ff108f42eb9b817ec5691f3482
Autor:
Leonard R. Pelgrom, Gavin M. Davis, Simon O’Shaughnessy, Emilie J.M. Wezenberg, Sander I. Van Kasteren, David K. Finlay, Linda V. Sinclair
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112828- (2023)
Summary: System-level analysis of single-cell data is rapidly transforming the field of immunometabolism. Given the competitive demand for nutrients in immune microenvironments, there is a need to understand how and when immune cells access these nut
Externí odkaz:
https://doaj.org/article/f8ed02eb6f6c4fc3b2176333693c7e6f
Autor:
Willemijn van der Wulp, Anna M. Gram, Boris Bleijlevens, Renate S. Hagedoorn, Can Araman, Robbert Q. Kim, Jan Wouter Drijfhout, Paul W. H. I. Parren, Richard G. Hibbert, Rob C. Hoeben, Sander I. van Kasteren, Janine Schuurman, Maaike E. Ressing, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to i
Externí odkaz:
https://doaj.org/article/458e15a064ab40b08049bc6f97a6578d
Autor:
Floris J. van Dalen, Thomas Bakkum, Tyrza van Leeuwen, Mirjam Groenewold, Edgar Deu, Abraham J. Koster, Sander I. van Kasteren, Martijn Verdoes
Publikováno v:
Frontiers in Chemistry, Vol 8 (2021)
Cathepsin S is a lysosomal cysteine protease highly expressed in immune cells such as dendritic cells, B cells and macrophages. Its functions include extracellular matrix breakdown and cleavage of cell adhesion molecules to facilitate immune cell mot
Externí odkaz:
https://doaj.org/article/0e57f5aafb46434b937c798381c0488d
Autor:
Bowen Fan, Diana Torres García, Marziye Salehi, Matthew J. Webber, Sander I. van Kasteren, Rienk Eelkema
Publikováno v:
Nature Chemical Biology, 18(3)
Dextran-based hydrogels are promising therapeutic materials for drug delivery, tissue regeneration devices, and cell therapy vectors, due to their high biocompatibility, along with their ability to protect and release active therapeutic agents. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb954c75495f75bf360be44442347a3
https://doi.org/10.1021/acschembio.2c00938
https://doi.org/10.1021/acschembio.2c00938
Autor:
Diana Torres-García, Merel A. T. van de Plassche, Emma van Boven, Tyrza van Leeuwen, Mirjam G. J. Groenewold, Alexi J. C. Sarris, Luuk Klein, Herman S. Overkleeft, Sander I. van Kasteren
Publikováno v:
RSC Chemical Biology, 3(11), 1325-1330. ROYAL SOC CHEMISTRY
Bioorthogonal chemistry combines well with activity-based protein profiling, as it allows for the introduction of detection tags without significantly influencing the physiochemical and biological functions of the probe. In this work, we introduced m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0bda1d05d8c8f55b116c8859d7773c
http://hdl.handle.net/1887/3497774
http://hdl.handle.net/1887/3497774
Autor:
Ward Doelman, Sander I. van Kasteren
Publikováno v:
Organic and Biomolecular Chemistry
Protein glycosylation is a key post-translational modification important to many facets of biology. Glycosylation can have critical effects on protein conformation, uptake and intracellular routing. In immunology, glycosylation of antigens has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88934f930f6b45f85f46889ed7637d13
https://hdl.handle.net/1887/3453347
https://hdl.handle.net/1887/3453347
Autor:
Can Araman, Mikkel H. S. Marqvorsen, Sander I. van Kasteren, Yvette van Kooyk, Ward Doelman, Fabrizio Chiodo, Sven C. M. Bruijns, Gijsbert A. van der Marel
Publikováno v:
Chemistry-a European Journal
Chemistry-A European Journal, 27(8), 2742-2752. Wiley-VCH Verlag
Doelman, W, Marqvorsen, M H S, Chiodo, F, Bruijns, S C M, van der Marel, G A, van Kooyk, Y, van Kasteren, S I & Araman, C 2021, ' Synthesis of Asparagine Derivatives Harboring a Lewis X Type DC-SIGN Ligand and Evaluation of their Impact on Immunomodulation in Multiple Sclerosis ', Chemistry-A European Journal, vol. 27, no. 8, pp. 2742-2752 . https://doi.org/10.1002/chem.202004076, https://doi.org/10.1002/chem.202004076
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-A European Journal, 27(8), 2742-2752. Wiley-VCH Verlag
Doelman, W, Marqvorsen, M H S, Chiodo, F, Bruijns, S C M, van der Marel, G A, van Kooyk, Y, van Kasteren, S I & Araman, C 2021, ' Synthesis of Asparagine Derivatives Harboring a Lewis X Type DC-SIGN Ligand and Evaluation of their Impact on Immunomodulation in Multiple Sclerosis ', Chemistry-A European Journal, vol. 27, no. 8, pp. 2742-2752 . https://doi.org/10.1002/chem.202004076, https://doi.org/10.1002/chem.202004076
Chemistry (Weinheim an Der Bergstrasse, Germany)
The protein myelin oligodendrocyte glycoprotein (MOG) is a key component of myelin and an autoantigen in the disease multiple sclerosis (MS). Post‐translational N‐glycosylation of Asn31 of MOG seems to play a key role in modulating the immune res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2984a3b3e6f76a64cafe3e324229db2
https://doi.org/10.1002/chem.202004076
https://doi.org/10.1002/chem.202004076
Autor:
Kristine Bertheussen, Merel van de Plassche, Thomas Bakkum, Berend Gagestein, Iakovia Ttofi, Alexi J. C. Sarris, Herman S. Overkleeft, Mario van der Stelt, Sander I. van Kasteren
Publikováno v:
Angewandte Chemie (International Edition), 61(38):e202207640
In the field of lipid research, bioorthogonal chemistry has made the study of lipid uptake and processing in living systems possible, whilst minimising biological properties arising from detectable pendant groups. To allow the study of unsaturated fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc32beabe9c0b2e279b551782a236e8
https://pubmed.ncbi.nlm.nih.gov/35838324
https://pubmed.ncbi.nlm.nih.gov/35838324