Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Sander H Diks"'
Autor:
Walderik W Zomerman, Sabine L A Plasschaert, Sander H Diks, Harm-Jan Lourens, Tiny Meeuwsen-de Boer, Eelco W Hoving, Wilfred F A den Dunnen, Eveline S J M de Bont
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141381 (2015)
Recent clinical trials investigating receptor tyrosine kinase (RTK) inhibitors showed a limited clinical response in medulloblastoma. The present study investigated the role of micro-environmental growth factors expressed in the brain, such as HGF an
Externí odkaz:
https://doaj.org/article/5cc2fac56e72485cb22ab36f73ad09b0
Autor:
Karla C S Queiroz, Renato Milani, Roberta R Ruela-de-Sousa, Gwenny M Fuhler, Giselle Z Justo, Willian F Zambuzzi, Nelson Duran, Sander H Diks, C Arnold Spek, Carmen V Ferreira, Maikel P Peppelenbosch
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45362 (2012)
It is now generally recognised that different modes of programmed cell death (PCD) are intimately linked to the cancerous process. However, the mechanism of PCD involved in cancer chemoprevention is much less clear and may be different between types
Externí odkaz:
https://doaj.org/article/59ad423b04b44b55ba702c93971bd05e
Autor:
Arie J Hoogendijk, Sander H Diks, Tom van der Poll, Maikel P Peppelenbosch, Catharina W Wieland
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18519 (2011)
BackgroundPneumonia represents a major health burden. Previous work demonstrated that although the induction of inflammation is important for adequate host defense against pneumonia, an inability to regulate the host's inflammatory response within th
Externí odkaz:
https://doaj.org/article/b42593a1cb3d4abe8ab8aa22bd22f79d
Autor:
Maria A Sartori da Silva, Jin-Ming Tee, Judith Paridaen, Anke Brouwers, Vincent Runtuwene, Danica Zivkovic, Sander H Diks, Daniele Guardavaccaro, Maikel P Peppelenbosch
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14023 (2010)
ECS (Elongin BC-Cul2/Cul5-SOCS-box protein) ubiquitin ligases recruit substrates to E2 ubiquitin-conjugating enzymes through a SOCS-box protein substrate receptor, an Elongin BC adaptor and a cullin (Cul2 or Cul5) scaffold which interacts with the RI
Externí odkaz:
https://doaj.org/article/fc06b93860674e68a01af6ddf697a006
Autor:
Malgorzata Miller, Stefanie Donat, Sonja Rakette, Thilo Stehle, Thijs R H M Kouwen, Sander H Diks, Annette Dreisbach, Ewoud Reilman, Katrin Gronau, Dörte Becher, Maikel P Peppelenbosch, Jan Maarten van Dijl, Knut Ohlsen
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9057 (2010)
In eukaryotic cell types, virtually all cellular processes are under control of proline-directed kinases and especially MAP kinases. Serine/threonine kinases in general were originally considered as a eukaryote-specific enzyme family. However, recent
Externí odkaz:
https://doaj.org/article/fd65f1db7980449fbc7788397e63a8a0
Autor:
Tita Ritsema, David Brodmann, Sander H Diks, Carina L Bos, Vinay Nagaraj, Corné M J Pieterse, Thomas Boller, Andres Wiemken, Maikel P Peppelenbosch
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6605 (2009)
External sugar initiates biosynthesis of the reserve carbohydrate fructan, but the molecular processes mediating this response remain obscure. Previously it was shown that a phosphatase and a general kinase inhibitor hamper fructan accumulation. We u
Externí odkaz:
https://doaj.org/article/48776519bc15441c8d82a87898c150b6
Autor:
Kaushal Parikh, Sander H Diks, Jurriaan H B Tuynman, Auke Verhaar, Mark Löwenberg, Daan W Hommes, Jos Joore, Akhilesh Pandey, Maikel P Peppelenbosch
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6440 (2009)
Kinases are pivotal regulators of cellular physiology. The human genome contains more than 500 putative kinases, which exert their action via the phosphorylation of specific substrates. The determinants of this specificity are still only partly under
Externí odkaz:
https://doaj.org/article/ecd0acc24e734dda90ae7bf8d8177e69
Autor:
Sander H Diks, Kaushal Parikh, Marijke van der Sijde, Jos Joore, Tita Ritsema, Maikel P Peppelenbosch
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e777 (2007)
BackgroundReversible phosphorylation catalysed by kinases is probably the most important regulatory mechanism in eukaryotes.Methodology/principal findingsWe studied the in vitro phosphorylation of peptide arrays exhibiting the majority of PhosphoBase
Externí odkaz:
https://doaj.org/article/4522e0af54bc4070bf2b1e8df4cb5cae
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Supplementary Figure 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff962a59ad7c870cf3bee0c54752aee
https://doi.org/10.1158/0008-5472.22379220.v1
https://doi.org/10.1158/0008-5472.22379220.v1
Autor:
Eveline S.J.M. de Bont, Maikel P. Peppelenbosch, Willem A. Kamps, Rik de Wijn, Piet J. Boender, Rob Ruijtenbeek, Eelco W. Hoving, Frank J.G. Scherpen, Arja ter Elst, Wilfred F.A. den Dunnen, Sander H. Diks, Arend H. Sikkema
Supplementary Figure 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219430cf2ab4aac459e615067654fdb9
https://doi.org/10.1158/0008-5472.22379223
https://doi.org/10.1158/0008-5472.22379223