Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities

Autor: Harrie Besselink, Bérénice Collet, Bart van der Burg, Sander C. van der Linden, Matthijs Naderman, Abraham Brouwer, Irene Middelhof, Nadia el Abdellaoui, Eszter Simon, Hai yen Man

Publikováno v: Collet, B, Simon, E, van der Linden, S, el Abdellaoui, N, Naderman, M, Man, H Y, Middelhof, I, van der Burg, B, Besselink, H & Brouwer, A 2020, ' Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities ', Reproductive Toxicology, vol. 96, pp. 432-444 . https://doi.org/10.1016/j.reprotox.2019.05.011
Reproductive Toxicology, 96, 432-444. Elsevier Inc.

We developed a thyroid testing panel to assess endocrine disrupting chemicals (EDCs) capacities to bind either the thyroid receptor β (TRβ) or the thyroid hormones transporter transthyretin (TTR). We first stably transfected a human U2OS cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a19defddf0deb3321d21e885db3a85
https://doi.org/10.1016/j.reprotox.2019.05.011

Identification of Major Dioxin-Like Compounds and Androgen Receptor Antagonist in Acid-Treated Tissue Extracts of High Trophic-Level Animals

Autor: Go Suzuki, Shin Takahashi, Tadasu K. Yamada, Masayuki Someya, Bart van der Burg, Abraham Brouwer, Shinsuke Tanabe, Tomohiko Isobe, Sander C. van der Linden, Yuko Tajima, Marja H. Lamoree, Martin van Velzen, Nguyen Minh Tue, Hidetaka Takigami

Publikováno v: Suzuki, G, Tue, N M, van der Linden, S C, Brouwer, A, van der Burg, B, van Velzen, M J M, Lamoree, M H, Someya, M, Takahashi, S, Isobe, T, Tajima, S, Yamada, T K, Takigami, H & Tanabe, S 2011, ' Identification of major dioxin-like compounds and androgen receptor antagonist in acid-treated tissue extracts of high trophic-level animals ', Environmental Science and Technology, vol. 45, pp. 10203-10211 . https://doi.org/10.1021/es2024274
Environmental Science and Technology, 45, 10203-10211. American Chemical Society

We evaluated the applicability of combining in vitro bioassays with instrument analyses to identify potential endocrine disrupting pollutants in sulfuric acid-treated extracts of liver and/or blubber of high trophic-level animals. Dioxin-like and and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07b7646c198d87aeff1f635b0604c34
https://doi.org/10.1021/es2024274

An in vitro/in vovo screening assay as a sensitive tool to assess endocrine disruptive activity in surface water

Autor: Bart van der Burg, Selinda de Vries-Buitenweg, Sander C. van der Linden, L.M. Puijker, Juliette Legler, Raoul V. Kuiper, Albertinka J. Murk, Rinus Bogers, Beppy van de Waart, Ine Geuijen

Publikováno v: Environment International, 33(3), 292-301
Environment International 33 (2007) 3
Environment International, 33(3), 292-301. Elsevier Limited
Environment International, Vol 33, Iss 3, Pp 292-301 (2007)
Borgers, R, De Vries-Buitenweg, S, Geuijen, I, De Roode, D, Kuiper, R, Van der Linden, S, Puiker, L, Murk, A J, Van der Burg, B & Legler, J 2007, ' An in vitro/in vivo screening assay as a sensitive tool to assess endocrine disruptive activity in surface water ', Environment International, vol. 33, no. 3, pp. 292-301 . https://doi.org/10.1016/j.envint.2006.10.002

Adult male fathead minnow were exposed for 14 or 28-days under flow-through conditions to undiluted filtered water samples from the rivers Meuse and Rhine in the Netherlands. The experiment included two vessels per treatment each containing 10 fish a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5a0de6e58d9be6c719f3761d7f4fc3
https://doi.org/10.1016/j.envint.2006.10.002

A high throughput screening system for predicting chemically-induced reproductive organ deformities

Autor: Aldert H. Piersma, Emiel Rorije, Sander C. van der Linden, Hai-Yen Man, Harrie Buist, B. Pieterse, Inge Mangelsdorf, Bart van der Burg, Andre Wolterbeek, Geertje Lewin, Barbara M.A. van Vugt-Lussenburg, E. Dinant Kroese

Publikováno v: Reproductive toxicology (Elmsford, N.Y.). 55

There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. Previously we followed a pragmatic approach using readily available tests, which was successful in predic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbce3bbd2db96b7b89a6ddba17894baf
https://pubmed.ncbi.nlm.nih.gov/25527862

Development of a panel of high-throughput reporter-gene assays to detect genotoxicity and oxidative stress

Autor: Cyrille Krul, Sander C. van der Linden, Anne R.M. von Bergh, Bart van der Burg, Barbara M.A. van Vught-Lussenburg, Lydia R.A. Jonker, Marc Teunis

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis. 760

The lack of toxicological information on many of the compounds that humans use or are exposed to, intentionally or unintentionally, poses a big problem in risk assessment. To fill this data gap, more emphasis is given to fast in vitro screening tools

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01d3f3fa0a14006db1431de6c8700ff
https://pubmed.ncbi.nlm.nih.gov/24362253