Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex

Autor: Marie-Paule E. van Engelen, Sander C. J. Verfaillie, Annemieke Dols, Mardien L. Oudega, Ronald Boellaard, Sandeep S. V. Golla, Marijke den Hollander, Rik Ossenkoppele, Philip Scheltens, Bart N. M. van Berckel, Yolande A. L. Pijnenburg, Everard G. B. Vijverberg

Publikováno v: EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Background Behavioural symptoms and frontotemporal hypometabolism overlap between behavioural variant of frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), hampering diagnostic distinction. Voxel-wise comparisons of bra

Externí odkaz: https://doaj.org/article/2e33ccec1e054043a8dbf5dff021fd33

Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case–control study (VeCosCO)

Autor: Frederik Barkhof, Johanna M A Visser-Meily, Maria Prins, Janneke Horn, Menno D de Jong, Arjen J C Slooter, Caroline M van Heugten, Denise Visser, Michele van Vugt, Hanneke E Hulst, Nelleke Tolboom, Bart N M van Berckel, Dook W Koch, Godelieve de Bree, Cees C van den Wijngaard, Tessa van der Maaden, Anouk Verveen, Sander C J Verfaillie, Irene Csorba, Emma M Coomans, Brent Appelman, Ronald Boellaard, Elsmarieke M van de Giessen, Sandeep Golla, Tanja A Kuut, Yvonne M G van Os, P T Nieuwkerk, H Knoop

Publikováno v: BMJ Open, Vol 13, Iss 6 (2023)

Introduction The risk factors for persistent fatigue and cognitive complaints after infection with SARS-CoV-2 and the underlying pathophysiology are largely unknown. Both clinical factors and cognitive-behavioural factors have been suggested to play

Externí odkaz: https://doaj.org/article/e696799c650c4ba8830baf18716f9f63

In vivo tau pathology is associated with synaptic loss and altered synaptic function

Autor: Emma M. Coomans, Deborah N. Schoonhoven, Hayel Tuncel, Sander C. J. Verfaillie, Emma E. Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P. Sweeney, J. Michael Ryan, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S. V. Golla, Arjan Hillebrand, Alida A. Gouw, Bart N. M. van Berckel

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)

Abstract Background The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investi

Externí odkaz: https://doaj.org/article/0311b602bb364b2b9a39d6b57ce39995

Tau pathology as determinant of changes in atrophy and cerebral blood flow

Autor: Denise Visser, Sander C. J. Verfaillie, Iris Bosch, Iman Brouwer, Hayel Tuncel, Emma M. Coomans, Roos M. Rikken, Sophie E. Mastenbroek, Sandeep S. V. Golla, Frederik Barkhof, Elsmarieke van de Giessen, Bart N. M. van Berckel, Wiesje M. van der Flier, Rik Ossenkoppele

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 50(8), 2409-2419. Springer Verlag
Visser, D, Verfaillie, S C J, Bosch, I, Brouwer, I, Tuncel, H, Coomans, E M, Rikken, R M, Mastenbroek, S E, Golla, S S V, Barkhof, F, van de Giessen, E, van Berckel, B N M, van der Flier, W M & Ossenkoppele, R 2023, ' Tau pathology as determinant of changes in atrophy and cerebral blood flow : a multi-modal longitudinal imaging study ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 50, no. 8, pp. 2409-2419 . https://doi.org/10.1007/s00259-023-06196-2

Purpose Tau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59aaf4513d266a4438b0d9a124af4e9
https://doi.org/10.1007/s00259-023-06196-2

Personalized risk for clinical progression in cognitively normal subjects—the ABIDE project

Autor: Ingrid S. van Maurik, Rosalinde E. R. Slot, Sander C. J. Verfaillie, Marissa D. Zwan, Femke H. Bouwman, Niels D. Prins, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Mike P. Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof, Wiesje M. van der Flier, for the Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-9 (2019)

Abstract Background Biomarkers such as cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) have predictive value for progression to dementia in patients with mild cognitive impairment (MCI). The pre-dementia stage takes far longer, and the

Externí odkaz: https://doaj.org/article/7831d97eb01d4cd0b5661ab2cfc9c4c5