Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sander Busker"'
Autor:
Jan G. Felber, Lena Poczka, Karoline C. Scholzen, Lukas Zeisel, Martin S. Maier, Sander Busker, Ulrike Theisen, Christina Brandstädter, Katja Becker, Elias S. J. Arnér, Julia Thorn-Seshold, Oliver Thorn-Seshold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Cyclic five-membered disulfides (1,2-dithiolanes) have been reported either as nonspecific redox motifs, or as highly specific cellular probes for thioredoxin reductase (TrxR). Here the authors show that 1,2-dithiolane probes are nonspecifically redu
Externí odkaz:
https://doaj.org/article/d91e7f3ce64641b1a587ffd99090ce7f
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101646- (2020)
The transcription factor STAT3 plays a key role in cancer and immunity, being widely explored as a potential drug target for the development of novel immunomodulatory or anticancer therapeutics. The mechanisms of small molecule-derived inhibition of
Externí odkaz:
https://doaj.org/article/59459af66d3f4eccbc09d83825b6ca5e
Autor:
Iryna Kolosenko, Yasmin Yu, Sander Busker, Matheus Dyczynski, Jianping Liu, Martin Haraldsson, Caroline Palm Apergi, Thomas Helleday, Katja Pokrovskaja Tamm, Brent D G Page, Dan Grander
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178844 (2017)
Activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been linked to several processes that are critical for oncogenic transformation, cancer progression, cancer cell proliferation, survival, drug resistance and metastasis. Inh
Externí odkaz:
https://doaj.org/article/3c35e110683a4648b5aa13008599cdad
Publikováno v:
ACS Chemical Biology. 15:1842-1851
Signal transducer and activator of transcription (STAT) proteins have important biological functions; however, deregulation of STAT signaling is a driving force behind the onset and progression of inflammatory diseases and cancer. While their biologi
Autor:
Karoline Scholzen, Julia Thorn-Seshold, Sander Busker, Katja Becker, Elias S.J. Arnér, Lena Poczka, Jan G Felber, Lukas Zeisel, Martin S. Maier, Oliver Thorn-Seshold, Christina Brandstädter, Ulrike Theisen
Specialised cellular networks of oxidoreductases coordinate the dithiol/disulfide-exchange reactions that control metabolism, protein regulation, and redox homeostasis. For probes to be selective for redox enzymes and effector proteins (nM to µM con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc942b3e6ad1bbbbf902dd28ad8fde8
https://doi.org/10.26434/chemrxiv.14270444.v1
https://doi.org/10.26434/chemrxiv.14270444.v1
Autor:
Sander Busker, Elias S.J. Arnér, Katja Becker, Karoline Scholzen, Lena Poczka, Oliver Thorn-Seshold, Kristina Loy, Lukas Zeisel, Jan G Felber, Ulrike Theisen, Christina Brandstädter, Julia Ahlfeld, MartinS. Maier
The cyclic five-membered disulfide 1,2-dithiolane has been used as the key element in numerous chemical biology probes. Contradictory views of this disulfide motif populate the literature: some reports describe it as being nonspecifically reduced, ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287e20fbb3865e8d63161253d4f08fc0
https://doi.org/10.26434/chemrxiv.13483155.v1
https://doi.org/10.26434/chemrxiv.13483155.v1
Autor:
Iryna Kolosenko, Jianping Liu, Lars-Olof Johansson, Wang Qian, B. Espinosa, Sander Busker, K. Pokrovskaja Tamm, Elias S.J. Arnér, Sanaz Attarha, Brent D. G. Page, Martin Haraldsson, Dan Grandér, Markus Dagnell
Publikováno v:
Science Advances
Redox regulation of STAT3 is targeted by direct inhibition of TrxR1, illuminating a promising link for therapeutic development.
Because of its key role in cancer development and progression, STAT3 has become an attractive target for developing n
Because of its key role in cancer development and progression, STAT3 has become an attractive target for developing n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1ddddf8c178f54a926413bea7cc21f
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169887
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169887
Autor:
Iryna Kolosenko, Matthieu Desroses, Thomas Helleday, Sander Busker, Juan Astorga-Wells, Dan Grandér, Sanaz Attarha, Roman A. Zubarev, Brent D. G. Page
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 160:80-88
STAT3 protein is an established target for the development of new cancer therapeutic agents. Despite lacking a traditional binding site for small molecule inhibitors, many STAT3 inhibitors have been identified and explored for their anti-cancer activ
Autor:
Sander Busker, J Eliveld, Ewout Foppen, Andries Kalsbeek, Mariëtte T. Ackermans, Ellen A. Fliers, Eveline Bruinstroop
Publikováno v:
International journal of obesity (2005), 39(11), 1655-1658. Nature Publishing Group
International Journal of Obesity, 39(11), 1655-8. Nature Publishing Group
International Journal of Obesity, 39(11), 1655-8. Nature Publishing Group
Human and animal studies increasingly point toward a neural pathogenesis of the metabolic syndrome, involving hypothalamic and autonomic nervous system dysfunction. We hypothesized that increased very-low-density lipoprotein-triglyceride (VLDL-TG) se
Autor:
Jianping Liu, Brent D. G. Page, Matheus Dyczynski, Katja Pokrovskaja Tamm, Yasmin Yu, Martin Haraldsson, Thomas Helleday, Dan Grandér, Sander Busker, Caroline Palm Apergi, Iryna Kolosenko
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178844 (2017)
PLoS ONE
PLoS ONE
Activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been linked to several processes that are critical for oncogenic transformation, cancer progression, cancer cell proliferation, survival, drug resistance and metastasis. Inh