Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Sander, Kooijman"'
Autor:
Peter Kip, Thijs J. Sluiter, Michael R. MacArthur, Ming Tao, Nicky Kruit, Sarah J. Mitchell, Jonathan Jung, Sander Kooijman, Josh Gorham, Jonathan G. Seidman, Paul H. A. Quax, Julius L. Decano, Masanori Aikawa, C. Keith Ozaki, James R. Mitchell, Margreet R. de Vries
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find
Externí odkaz:
https://doaj.org/article/8f299f54c6294dc69d98482c052be4d7
Autor:
Melanie Modder, Claudia P. Coomans, Dirk-Jan Saaltink, Mayke M. H. Tersteeg, Janna Hoogduin, Leonie Scholten, Amanda C. M. Pronk, Reshma A. Lalai, Anita Boelen, Andries Kalsbeek, Patrick C. N. Rensen, Erno Vreugdenhil, Sander Kooijman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Crosstalk between peripheral metabolic organs and the central nervous system is essential for body weight control. At the base of the hypothalamus, β-tanycytes surround the portal capillaries and function as gatekeepers to facilitate transf
Externí odkaz:
https://doaj.org/article/dfe49dbfc38e4ce386cd77ee4e307ebf
Autor:
Carlijn A Hoekx, Borja Martinez-Tellez, Maaike E Straat, Magdalena M A Verkleij, Mirjam Kemmeren, Sander Kooijman, Martin Uhrbom, Saskia C A de Jager, Patrick C N Rensen, Mariëtte R Boon
Publikováno v:
Endocrine Connections, Vol 13, Iss 7, Pp 1-10 (2024)
Objectives: Cold exposure is linked to cardiometabolic benefits. Cold activates brown adipose tissue (BAT), increases energy expenditure, and induces secretion of the hormones fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (
Externí odkaz:
https://doaj.org/article/0be410fb04c2444f94093ce16ab04b39
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 9, Pp 100617- (2024)
Brown adipose tissue (BAT) combusts lipids and glucose to generate heat. Via this process of nonshivering thermogenesis, BAT plays a pivotal role in thermoregulation in cold environments, but its contribution to immune-induced fever is less clear. Ma
Externí odkaz:
https://doaj.org/article/4b08b1e6041746ea94847da3a9c9fda1
Publikováno v:
Vascular Biology, Vol 6, Iss 1, Pp 1-15 (2024)
Cardiovascular disease, the primary cause of human mortality globally, is predominantly caused by a progressive disorder known as atherosclerosis. Atherosclerosis refers to the process of accumulation of cholesterol-enriched lipoproteins and the conc
Externí odkaz:
https://doaj.org/article/c5d9e72590744d24b771f1c41a6dda88
Autor:
Xiaoke Ge, Bram Slütter, Joost M. Lambooij, Enchen Zhou, Zhixiong Ying, Ceren Agirman, Marieke Heijink, Antoine Rimbert, Bruno Guigas, Johan Kuiper, Christoph Müller, Franz Bracher, Martin Giera, Sander Kooijman, Patrick C.N. Rensen, Yanan Wang, Milena Schönke
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109830- (2024)
Summary: The liver X receptor (LXR) is considered a therapeutic target for atherosclerosis treatment, but synthetic LXR agonists generally also cause hepatic steatosis and hypertriglyceridemia. Desmosterol, a final intermediate in cholesterol biosynt
Externí odkaz:
https://doaj.org/article/d72d912914924864b6d5ff9166b6b6a7
Autor:
Ida Gregersen, Xiang Y. Kong, Sander Kooijman, Håvard Foyn, Helene Grannes, Maria B. Olsen, Anna M. Lone, Kuan Yang, Ana Quiles-Jiménez, Marianne Tran, Jonas Øgaard, Filip M. Segers, Azita Rashidi, Ellen Lund Sagen, Knut H. Lauritzen, Amanda C.M. Pronk, Jan Freark de Boer, Kirsten B. Holven, Espen Melum, Pål Aukrust, Kjetil Taskén, Sverre Holm, Patrick C.N. Rensen, Tuva B. Dahl, Bente Halvorsen
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109471- (2024)
Summary: Obesity is a complex multicausal disease that can cause morbidity and mortality, and there is need for improved knowledge on the underlying mechanisms. Using a mouse model of increased T cell responsiveness, we show that development of obesi
Externí odkaz:
https://doaj.org/article/4eebcfac72e641d6a1735c3f7f6c06bf
Publikováno v:
Stress, Vol 0, Iss 0, Pp 1-11 (2023)
Glucocorticoid hormones are essential for health, but overexposure may lead to many detrimental effects, including metabolic, psychiatric, and bone disease. These effects may not only be due to increased overall exposure to glucocorticoids, but also
Externí odkaz:
https://doaj.org/article/29c0316ce2ed48a2ad6a252a52a44d31
Autor:
Rosalie G. J. Rietjens, Gangqi Wang, Anouk I. M. van der Velden, Angela Koudijs, M. Cristina Avramut, Sander Kooijman, Patrick C. N. Rensen, Johan van der Vlag, Ton J. Rabelink, Bram Heijs, Bernard M. van den Berg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Diabetes is a main risk factor for kidney disease, causing diabetic nephropathy in close to half of all patients with diabetes. Metabolism has recently been identified to be decisive in cell fate decisions and repair. Here we used mass spect
Externí odkaz:
https://doaj.org/article/b63da834cde7487bb1afc2fd5be2ce99
Autor:
Wietse In Het Panhuis, Milena Schönke, Melanie Modder, Hannah E. Tom, Reshma A. Lalai, Amanda C.M. Pronk, Trea C.M. Streefland, Linda W.M. van Kerkhof, Martijn E.T. Dollé, Marie A.C. Depuydt, Ilze Bot, Winnie G. Vos, Laura A. Bosmans, Bram W. van Os, Esther Lutgens, Patrick C.N. Rensen, Sander Kooijman
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104680- (2023)
Summary: Background: Circadian disturbance (CD) is the consequence of a mismatch between endogenous circadian rhythms, behaviour, and/or environmental cycles, and frequently occurs during shift work. Shift work has been associated with elevated risk
Externí odkaz:
https://doaj.org/article/7688df68c73a447fbd0ed5759e20db0d