The C-terminal tail of ��-synuclein protects against aggregate replication but is critical for oligomerization

Autor: Farzadfard, Azad, Pedersen, Jannik Nedergaard, Meisl, Georg, Somavarapu, Arun Kumar, Alam, Parvez, Goks��yr, Louise, Nielsen, Morten Agertoug, Sander, Adam Frederik, Knowles, Tuomas, Pedersen, Jan Skov, Otzen, Daniel Erik

Aggregation of the 140-residue protein ��-synuclein (��SN) is a key factor in the etiology of Parkinson's disease. Although the intensely anionic C-terminal domain (CTD) of ��SN does not form part of the amyloid core region or affect memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b27e13019132208298c3ff70db6b517d

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A VAR2CSA:CSP conjugate capable of inducing dual specificity antibody responses

Autor: Kavishe Reginald Adolph, Janitzek Christoph Mikkel, Salanti Ali, Theander Thor Grundtvig, Mwakalinga Steven Boniface, Nielsen Morten Agertoug, Matondo Sungwa, Sander Adam Frederik, Thrane Susan

Publikováno v: Matondo, S, Thrane, S, Janitzek, C M, Kavishe, R A, Mwakalinga, S B, Theander, T G, Salanti, A, Nielsen, M A & Pedersen, A F S 2017, ' A VAR2CSA:CSP conjugate capable of inducing dual specificity antibody responses ', African Health Sciences, vol. 17, no. 2, pp. 373-381 . https://doi.org/10.4314/ahs.v17i2.11
African Health Sciences; Vol 17, No 2 (2017); 373-381

Background: Vaccine antigens targeting specific P. falciparum parasite stages are under pre-clinical and clinical development. It seems plausible that vaccine with multiple specificities will offer higher protection. With this hypothesis, we exploite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e78efdd9c1d6a87af42b5169893d020
https://curis.ku.dk/portal/da/publications/a-var2csacsp-conjugate-capable-of-inducing-dual-specificity-antibody-responses(40084bf8-5fec-46e6-bf67-07a7d1046430).html

The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization

Autor: Azad Farzadfard, Jannik Nedergaard Pedersen, Georg Meisl, Arun Kumar Somavarapu, Parvez Alam, Louise Goksøyr, Morten Agertoug Nielsen, Adam Frederik Sander, Tuomas P. J. Knowles, Jan Skov Pedersen, Daniel Erik Otzen

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Farzadfard, A, Pedersen, J N, Meisl, G, Somavarapu, A K, Alam, P, Goksøyr, L, Nielsen, M A, Sander, A F, Knowles, T P J, Pedersen, J S & Otzen, D E 2022, ' The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization ', Communications Biology, vol. 5, no. 1, 123 . https://doi.org/10.1038/s42003-022-03059-8

Aggregation of the 140-residue protein α-synuclein (αSN) is a key factor in the etiology of Parkinson’s disease. Although the intensely anionic C-terminal domain (CTD) of αSN does not form part of the amyloid core region or affect membrane bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9237247d582f2cd3810be8bf293e7b21
https://pubmed.ncbi.nlm.nih.gov/35145226