Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals

Autor: Fiona Heeman, Denise Visser, Maqsood Yaqub, Sander Verfaillie, Tessa Timmers, Yolande AL Pijnenburg, Wiesje M van der Flier, Bart NM van Berckel, Ronald Boellaard, Adriaan A Lammertsma, Sandeep SV Golla

Publikováno v: Journal of Cerebral Blood Flow and Metabolism. Nature Publishing Group
Heeman, F, Visser, D, Yaqub, M, Verfaillie, S, Timmers, T, Pijnenburg, Y A L, van der Flier, W M, van Berckel, B N M, Boellaard, R, Lammertsma, A A & Golla, S S V 2022, ' Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X221135270

Alzheimer’s disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [15O]H2O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9cd3633473d66d405ba791be0cad57
https://doi.org/10.1177/0271678x221135270

Tau protein spreads through functionally connected neurons in Alzheimer’s disease

Autor: Deborah N Schoonhoven, Emma M Coomans, Ana P Millan, Anne M van Nifterick, Denise Visser, Rik Ossenkoppele, Hayel Tuncel, Wiesje M. van der Flier, Sandeep SV Golla, Philip Scheltens, Arjan Hillebrand, Bart NM van Berckel, Cornelis J Stam, Alida A Gouw

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0677415f4305261ae7f0bb286d5ca6
https://doi.org/10.1002/alz.066494

Genetically identical twins are highly similar in levels and spatial distribution of tau pathology: A [ 18 F]flortaucipir PET study

Autor: Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep SV Golla, Marijke E den Hollander, Lyduine E. Collij, Emma Weltings, Nina Hoogland, Emma E Wolters, Albert D. Windhorst, Frederik Barkhof, Eco J.C. de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N.M. Van Berckel, Anouk den Braber

Publikováno v: Alzheimer's & Dementia. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1545a3061f369723d271394d4f41e3a8
https://doi.org/10.1002/alz.054879

Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer’s disease

Autor: Tessa Timmers, Sander C.J. Verfaillie, P. Scheltens, Sandeep Sv Golla, Emma M. Coomans, Emma E. Wolters, Albert D. Windhorst, Ronald Boellaard, Hayel Tuncel, W.M. van der Flier, B.N.M. van Berckel, Denise Visser, Rik Ossenkoppele

PurposeEarly-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing tau pathology and relative cerebral blood flow (rCBF) measured with [18F]flortauc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19f89fcdb1e7fd0328827c96ee5d00a1
https://doi.org/10.1101/2021.08.17.21262157

Grey zone amyloid burden affects memory function: the SCIENCe project

Autor: Sander C.J. Verfaillie, B.N.M. van Berckel, Frederik Barkhof, K. van den Bosch, Maqsood Yaqub, W.M. van der Flier, M. van Leeuwenstijn, Niels D. Prins, Tessa Timmers, Albert D. Windhorst, Linda M.P. Wesselman, Hayel Tuncel, Sandeep Sv Golla, P. Scheltens, Jarith L. Ebenau

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging
Ebenau, J L, Verfaillie, S C J, van den Bosch, K A, Timmers, T, Wesselman, L M P, van Leeuwenstijn, M, Tuncel, H, Golla, S V S, Yaqub, M M, Windhorst, A D, Prins, N D, Barkhof, F, Scheltens, P, van der Flier, W M & van Berckel, B N M 2020, ' Grey zone amyloid burden affects memory function : the SCIENCe project ', European Journal of Nuclear Medicine and Molecular Imaging . https://doi.org/10.1007/s00259-020-05012-5
European Journal of Nuclear Medicine and Molecular Imaging. Springer Verlag

Purpose To determine thresholds for amyloid beta pathology and evaluate associations with longitudinal memory performance with the aim to identify a grey zone of early amyloid beta accumulation and investigate its clinical relevance. Methods We inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c335f8b8c2fbfb04d23685e7726b828c
https://pubmed.ncbi.nlm.nih.gov/32888039