Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sandeep Somani"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Autor:
Aran F. Labrijn, Joyce I. Meesters, Matthew Bunce, Anthony A. Armstrong, Sandeep Somani, Tom C. Nesspor, Mark L. Chiu, Işil Altintaş, Sandra Verploegen, Janine Schuurman, Paul W. H. I. Parren
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Therapeutic concepts exploiting tumor-specific antibodies are often established in pre-clinical xenograft models using immuno-deficient mice. More complex therapeutic paradigms, however, warrant the use of immuno-competent mice, that more ac
Externí odkaz:
https://doaj.org/article/bbef8d706f08451bb51dc1be0939cbc2
Autor:
Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani, Sheng-Jiun Wu, Xuesong Liu, Alexis Gervais, Robin Ernst, Dorina Saro, Rose Decker, Jinquan Luo, Gary L. Gilliland, Mark L. Chiu, Bernard J. Scallon
Publikováno v:
Antibodies, Vol 6, Iss 3, p 12 (2017)
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamm
Externí odkaz:
https://doaj.org/article/e4effcd57176409f88ce8c9b266a42aa
Publikováno v:
Journal of Chemical Information and Modeling. 63:2857-2865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f1ae9fbbba6a2937bb1b21310525f2d
https://doi.org/10.1021/acs.jcim.3c00243
https://doi.org/10.1021/acs.jcim.3c00243
Autor:
Christopher Negron, Wenting Ma, Alexey Teplyakov, Winnie Chan, Sandeep Somani, Thomas J. Malia, Lauren E. Boucher, Gary L. Gilliland, Jinquan Luo, Galina Obmolova, Steven Jacobs
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 90:270-281
This study uses differential scanning calorimetry, X-ray crystallography and molecular dynamics simulations to investigate the structural basis for the high thermal stability (melting temperature 97.5 °C) of a FN3-like protein domain from thermophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee132e201b802ca70f181b7d191acbf
https://doi.org/10.1002/prot.26218
https://doi.org/10.1002/prot.26218
Autor:
Renuka Thirumangalathu, Vineet Kumar, Sandeep Somani, Danika Rodrigues, Laura M. Tanenbaum, Kai Zhang, Santosh V. Thakkar, Ketan Amin
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1077-1082
Developing ultra-high concentration biotherapeutics drug products can be challenging due to increased viscosity, processing, and stability issues. Excipients used to alleviate these concerns are traditionally evaluated at lower protein concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accc1180e9cf7d818479b91b63354427
https://doi.org/10.1016/j.xphs.2020.12.016
https://doi.org/10.1016/j.xphs.2020.12.016
Autor:
Santosh V. Thakkar, Danika Rodrigues, Bo Zhai, Dwaine Banton, Sandeep Somani, Alex Javidi, Andrew Mahan, Stuart Ember, Dominick DeGrazio, Subinay Ganguly, Ketan Amin, Hirsh Nanda
Publikováno v:
Journal of pharmaceutical sciences.
The rational design and selection of formulation composition to meet molecule-specific and product-specific needs are critical for biotherapeutics development to ensure physical and chemical stability. This work, based on three antibody-based (mAb) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82868a3378cdaad24636527f8bb1c1cf
https://pubmed.ncbi.nlm.nih.gov/36130676
https://pubmed.ncbi.nlm.nih.gov/36130676
Publikováno v:
Mol Pharm
Protein therapeutics typically require a concentrated protein formulation, which can lead to self-association and/or high viscosity due to protein-protein interaction (PPI). Excipients are often added to improve stability, bioavailability, and manufa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d5f702aa0e4d08d273fda577d01723
https://pubmed.ncbi.nlm.nih.gov/32965126
https://pubmed.ncbi.nlm.nih.gov/32965126
Autor:
Gary L. Gilliland, Mahidhar Tatineni, Bart van Beusekom, Robbie P. Joosten, Jinquan Luo, Gunaretnam Rajagopal, Sandeep Somani, Wouter G. Touw, Anastassis Perrakis
Publikováno v:
Protein Science. 27:798-808
The Protein Data Bank (PDB) is the global archive for structural information on macromolecules, and a popular resource for researchers, teachers, and students, amassing more than one million unique users each year. Crystallographic structure models i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37065b2da15d8a1c6504fa427c54abab
https://doi.org/10.1002/pro.3353
https://doi.org/10.1002/pro.3353
Autor:
Anthony A. Armstrong, Tom C. Nesspor, Joyce I. Meesters, Matthew Bunce, Isil Altintas, Sandra Verploegen, Janine Schuurman, Aran F. Labrijn, Sandeep Somani, Mark L. Chiu, Paul W. H. I. Parren
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Labrijn, A F, Meesters, J I, Bunce, M, Armstrong, A A, Somani, S, Nesspor, T C, Chiu, M L, Altintaş, I, Verploegen, S, Schuurman, J & Parren, P W H I 2017, ' Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models ', Scientific Reports, vol. 7, 2476 . https://doi.org/10.1038/s41598-017-02823-9
Scientific Reports
Labrijn, A F, Meesters, J I, Bunce, M, Armstrong, A A, Somani, S, Nesspor, T C, Chiu, M L, Altintaş, I, Verploegen, S, Schuurman, J & Parren, P W H I 2017, ' Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models ', Scientific Reports, vol. 7, 2476 . https://doi.org/10.1038/s41598-017-02823-9
Scientific Reports
Therapeutic concepts exploiting tumor-specific antibodies are often established in pre-clinical xenograft models using immuno-deficient mice. More complex therapeutic paradigms, however, warrant the use of immuno-competent mice, that more accurately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e2908b4120d2d1ca58d5fc5b194d56
https://doaj.org/article/bbef8d706f08451bb51dc1be0939cbc2
https://doaj.org/article/bbef8d706f08451bb51dc1be0939cbc2