Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sandeep Potluri"'
Autor:
Sophie G. Kellaway, Sandeep Potluri, Peter Keane, Helen J. Blair, Luke Ames, Alice Worker, Paulynn S. Chin, Anetta Ptasinska, Polina K. Derevyanko, Assunta Adamo, Daniel J. L. Coleman, Naeem Khan, Salam A. Assi, Anja Krippner-Heidenreich, Manoj Raghavan, Peter N. Cockerill, Olaf Heidenreich, Constanze Bonifer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating
Externí odkaz:
https://doaj.org/article/d6aa9401fa5141ad9c390f2a12d3bb12
Autor:
Vesna S. Stanulović, Shorog Al Omair, Michelle A.C. Reed, Jennie Roberts, Sandeep Potluri, Taylor Fulton-Ward, Nancy Gudgeon, Emma L. Bishop, Juliette Roels, Tracey A. Perry, Sovan Sarkar, Guy Pratt, Tom Taghon, Sarah Dimeloe, Ulrich L. Günther, Christian Ludwig, Maarten Hoogenkamp
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the immune system. Approximately 20% of paediatric and 50% of adult T-ALL patients have refractory disease or relapse and die from the disease. To improve patient outcome new therapeutics are
Externí odkaz:
https://doaj.org/article/89ee5f73be0d42d2909cf64e304355a7
Autor:
Daniel J.L. Coleman, Peter Keane, Paulynn S. Chin, Luke Ames, Sophie Kellaway, Helen Blair, Naeem Khan, James Griffin, Elizabeth Holmes, Alexander Maytum, Sandeep Potluri, Lara Strate, Kinga Koscielniak, Manoj Raghavan, John Bushweller, Olaf Heidenreich, Terry Rabbitts, Peter N. Cockerill, Constanze Bonifer
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109576- (2024)
Summary: AML is characterized by mutations in genes associated with growth regulation such as internal tandem duplications (ITD) in the receptor kinase FLT3. Inhibitors targeting FLT3 (FLT3i) are being used to treat patients with FLT3-ITD+ but most r
Externí odkaz:
https://doaj.org/article/ceddafe74d5942cfbc74b595d7a6e5e4
Autor:
Daniel J.L. Coleman, Peter Keane, Rosario Luque-Martin, Paulynn S. Chin, Helen Blair, Luke Ames, Sophie G. Kellaway, James Griffin, Elizabeth Holmes, Sandeep Potluri, Salam A. Assi, John Bushweller, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113568- (2023)
Summary: Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations. Previously, we showed that each mutational subtype develops its specific gene regulatory network (GRN) with transcription factors interacting within multi
Externí odkaz:
https://doaj.org/article/72be4bba0590424496380b929459cff5
Autor:
Moritz Binder, Ryan M. Carr, Terra L. Lasho, Christy M. Finke, Abhishek A. Mangaonkar, Christopher L. Pin, Kurt R. Berger, Amelia Mazzone, Sandeep Potluri, Tamas Ordog, Keith D. Robertson, David L. Marks, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Mrinal M. Patnaik
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
‘Mutations in the chromatin remodeler ASXL1 (ASXL1MT) are associated with poor clinical outcome, however, their impact on chromatin dynamics remains unexplored. Here the authors use a multi-omics approach for chronic myelomonocytic leukemia (CMML)
Externí odkaz:
https://doaj.org/article/81870b2649874a6f8f41f85549083775
Autor:
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia
Publikováno v:
eLife, Vol 11 (2022)
Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, whether
Externí odkaz:
https://doaj.org/article/247af8afae3341a19c89d1bd9c2e8c96
Autor:
Sandeep Potluri, Salam A. Assi, Paulynn S. Chin, Dan J.L. Coleman, Anna Pickin, Shogo Moriya, Naohiko Seki, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109010- (2021)
Summary: Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signaling machinery that control hematopoietic progenitor cell growth and differentiation. Here, we show that the transcription factor WT1 fo
Externí odkaz:
https://doaj.org/article/68152a737a1f4ceabce2e278ff45e786
Autor:
Sophie G Kellaway, Sandeep Potluri, Peter Keane, Helen J. Blair, Paulynn S Chin, Anetta Ptasinska, Alice Worker, Luke Ames, Assunta Adamo, Daniel JL Coleman, Naeem Khan, Salam A. Assi, Anja Krippner-Heidenreich, Manoj Raghavan, Peter N Cockerill, Olaf Heidenreich, Constanze Bonifer
SummaryAcute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8fad45ca94531921bd18c15689121f
https://doi.org/10.1101/2023.03.10.532081
https://doi.org/10.1101/2023.03.10.532081
Autor:
Victoria Stavrou, Livingstone Fultang, Sarah Booth, Daniele De Simone, Arekdiusz Bartnik, Ugo Scarpa, Luciana Gneo, Silvia Panetti, Sandeep Potluri, Meaad Almowaled, Jonathan Barlow, Andris Jankevics, Gavin Lloyd, Andrew Southam, David A. Priestman, Paul Cheng, Warwick Dunn, Frances Platt, Hitoshi Endou, Charles Craddock, Karen Keeshan, Francis Mussai, Carmela De Santo
Acute myeloid leukaemia (AML) creates an immunosuppressive environment to conventional T cells through Arginase 2 (ARG2)-induced arginine depletion. We identify that AML blasts release the acute phase protein serum amyloid A (SAA), which acts in an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7194899688dbd455a6f962fac909168
https://eprints.gla.ac.uk/277780/1/277780.pdf
https://eprints.gla.ac.uk/277780/1/277780.pdf
Autor:
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8727f2ae9314465ba307e260125acf7c
https://doi.org/10.7554/elife.75908.sa2
https://doi.org/10.7554/elife.75908.sa2