Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Sandeep Modi"'
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 9, Iss 9, Pp PD08-PD09 (2015)
Penetrating injuries of the brain are quite uncommon, comprising approximately 0.4% of all head injuries. In our case, a four-year-old boy who fell forward on a house-key (lock) accidentally while playing with some other children sustained a left si
Externí odkaz:
https://doaj.org/article/6bbf497f659e4409ab5b633c241c9d59
Autor:
William Masinja, Elizabeth F. McInnes, Mark T. D. Cronin, Claire Elliott, Sandeep Modi, Richard A. Currie, Steven J. Enoch
Publikováno v:
Toxicology in Vitro. 70:105017
Alternatives to mammalian testing are highly desirable to predict the skin sensitisation potential of agrochemical active ingredients (AI). The GARD assay, a stimulated, dendritic cell-like, cell line measuring genomic signatures, was evaluated using
Publikováno v:
Drug Discovery Today. 17:135-142
In silico toxicology prediction is an extremely challenging area because many toxicological effects are a result of changes in multiple physiological processes. In this article we discuss limitations and strengths of these in silico tools. Additional
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:5906-5919
A systematic analysis of data generated in key in vitro assays within GSK has been undertaken to identify what impact a range of common substituents have on a range of ADMET parameters. These include; P450 1A2, 2C9, 2C19, 2D6 and 3A4 inhibition, hERG
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 9, Iss 9, Pp PD08-PD09 (2015)
Penetrating injuries of the brain are quite uncommon, comprising approximately 0.4% of all head injuries. In our case, a four-year-old boy who fell forward on a house-key (lock) accidentally while playing with some other children sustained a left sid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7637ff38a15a886e73d5230a416de1
https://europepmc.org/articles/PMC4606277/
https://europepmc.org/articles/PMC4606277/
Autor:
John Delaney, Sarah Whalley, David Cowie, Nathan Kidley, Caroline Winn, Paul Rawlinson, Aniko Kende, Ryan Richards-Doran, Sandeep Modi, Lauraine Swindale, Richard A. Currie
Publikováno v:
Reproductive Toxicology. 72:19
Autor:
Sandeep Modi, Gary R. Manchee, Anne Hersey, Robert M. Cooke, Harren Jhoti, Anne Cleasby, Margarete Neu, Alan J. Wonacott, Alan M. Hood, Jyrki Taskinen, Michael W.H. Coughtrie, Rana Dajani
Publikováno v:
Journal of Biological Chemistry. 274:37862-37868
Humans are one of the few species that produce large amounts of catecholamine sulfates, and they have evolved a specific sulfotransferase, SULT1A3 (M-PST), to catalyze the formation of these conjugates. An orthologous protein has yet to be found in o
Autor:
Michael J. Sutcliffe, Michael Patrick Pritchard, Sandeep Modi, Gillian Smith, Thomas Friedberg, L. Y. Lian, G. C. K. Roberts, I. Pillai, C R Wolf
Publikováno v:
Scopus-Elsevier
Cytochrome P-450 CYP2D6, human debrisoquine hydroxylase, metabolizes more than 30 prescribed drugs, the vast majority of which are small molecules containing a basic nitrogen atom. In contrast, the similar mouse protein Cyp2d-9 was first characterize
Autor:
Sandeep Modi, C R Wolf, David E. Gilham, Lu-Yun Lian, W. U. Primrose, Michael J. Sutcliffe, G. C. K. Roberts
Publikováno v:
Biochemistry. 36:4461-4470
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that produces Parkinsonism symptoms in man, has been examined as a substrate of recombinant human cytochrome P450 2D6. When cumene hydroperoxide is used as an oxygen and electron donor
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1339:79-87
Oxidation of substituted phenols by horseradish peroxidase compound II were studied using stopped-flow technique. Dissociation constants (KD) of HRP-II-phenol complexes were deduced from the kinetic data. Magnitudes of KD fall in a relatively narrow