Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sandeep Dembla"'
Autor:
Melih Özgür Celik, Viola Seitz, Fatih Yergöz, Sandeep Dembla, Nina Kathleen Blum, Stefan Schulz, Christoph Stein
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typical
Externí odkaz:
https://doaj.org/article/d24edb3270114fefa997af4d5bc07964
Autor:
Sandeep Dembla, Marc Behrendt, Florian Mohr, Christian Goecke, Julia Sondermann, Franziska M Schneider, Marlene Schmidt, Julia Stab, Raissa Enzeroth, Michael G Leitner, Paulina Nuñez-Badinez, Jochen Schwenk, Bernd Nürnberg, Alejandro Cohen, Stephan E Philipp, Wolfgang Greffrath, Moritz Bünemann, Dominik Oliver, Eleonora Zakharian, Manuela Schmidt, Johannes Oberwinkler
Publikováno v:
eLife, Vol 6 (2017)
Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which also causes important adverse effects. However, µORs are also found on the peripheral endi
Externí odkaz:
https://doaj.org/article/17777c9aaefd44fe844bae6c04dc63f5
Autor:
Melih Celik, Viola Seitz, Fatih Yergoz, Sandeep Dembla, Nina Blum, Stefan Schulz, Christoph Stein
Background and Purpose NFEPP is a newly-designed pain killer selectively activating G-protein coupled mu opioid receptors in injured tissues, and therefore devoid of central side effects. However, the cellular mechanisms underlying NFEPP’s antinoci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef7cec252eb2e21e488cc28c701d333c
https://doi.org/10.22541/au.165702074.41843063/v1
https://doi.org/10.22541/au.165702074.41843063/v1
Autor:
Doris Wagner, Siyuan Zhao, Tibor Rohacs, Stephan E. Philipp, Mieke Nys, Frederic Rousseau, Rodrigo Gallardo, Fabian Gruss, Sandeep Dembla, Marc Behrendt, Valentina Zorzini, Pierre-Antoine Crassous, Johannes Oberwinkler, Florian Mohr, Chris Ulens, Anastassios Economou, Joost Schymkowitz, Nikolaos N. Louros, Raissa Enzeroth
Publikováno v:
Proc Natl Acad Sci U S A
TRPM3 channels play important roles in the detection of noxious heat and in inflammatory thermal hyperalgesia. The activity of these ion channels in somatosensory neurons is tightly regulated by µ-opioid receptors through the signaling of Gβγ prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d7b0fe44d0172cfa8939a2514080f7
https://doi.org/10.1073/pnas.2001177117
https://doi.org/10.1073/pnas.2001177117
Autor:
Andreas Beck, Julia Przibilla, Johannes Oberwinkler, Annette Lis, Oleksandr Rizun, Martin Jung, Sandeep Dembla, Stephan E. Philipp
Publikováno v:
Cell Calcium. 73:40-52
TRPM3 proteins assemble to Ca2+-permeable cation channels in the plasma membrane, which act as nociceptors of noxious heat and mediators of insulin and cytokine release. Here we show that TRPM3 channel activity is strongly dependent on intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ec22df2c46117d03383236135c0117
https://doi.org/10.1016/j.ceca.2018.03.005
https://doi.org/10.1016/j.ceca.2018.03.005
Autor:
Bettina U. Wilke, Maik Konrad, Marlen Dierich, Johannes Oberwinkler, Niklas Michel, Marc Behrendt, Sandeep Dembla, Moritz Lindner, Michael G. Leitner, Dominik Oliver
Publikováno v:
British Journal of Pharmacology. 173:2555-2569
Background and Purpose Signalling through phospholipase C (PLC) controls many cellular processes. Much information on the relevance of this important pathway has been derived from pharmacological inhibition of the enzymatic activity of PLC. We found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de9bcc2a28dacb778e06bf2d385d0fa5
https://doi.org/10.1111/bph.13538
https://doi.org/10.1111/bph.13538
Publikováno v:
FEBS Letters. 590:1509-1520
Transient receptor potential A1 channels are well-known as chemosensors in neuronal cells. However, recent studies also point to non-neuronal functions in epithelia. Here, we show that TRPA1 channels are expressed in epithelial MDCK II cells and cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0779ba353137143d503aa51cdcc3e20b
https://doi.org/10.1002/1873-3468.12183
https://doi.org/10.1002/1873-3468.12183
Autor:
Julia, Przibilla, Sandeep, Dembla, Oleksandr, Rizun, Annette, Lis, Martin, Jung, Johannes, Oberwinkler, Andreas, Beck, Stephan E, Philipp
Publikováno v:
Cell calcium. 73
TRPM3 proteins assemble to Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25a5f5ca4dc96daea825e6ff6a09ec3b
https://pubmed.ncbi.nlm.nih.gov/29880196
https://pubmed.ncbi.nlm.nih.gov/29880196
Autor:
Michael G. Leitner, Marlene Schmidt, Jochen Schwenk, Franziska M Schneider, Moritz Bünemann, Bernd Nürnberg, Sandeep Dembla, Florian Mohr, Manuela Schmidt, Eleonora Zakharian, Marc Behrendt, Raissa Enzeroth, Johannes Oberwinkler, Paulina Nuñez-Badinez, Alejandro Cohen, Dominik Oliver, Julia Stab, Stephan E. Philipp, Christian Goecke, Julia Sondermann, Wolfgang Greffrath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541f6db98ed8903190c656660b79d3e8
https://doi.org/10.7554/elife.26280.035
https://doi.org/10.7554/elife.26280.035
Autor:
Moritz Bünemann, Eleonora Zakharian, Julia Stab, Paulina Nuñez-Badinez, Christian Goecke, Dominik Oliver, Julia Sondermann, Raissa Enzeroth, Marlene Schmidt, Alejandro Cohen, Jochen Schwenk, Johannes Oberwinkler, Wolfgang Greffrath, Franziska M Schneider, Florian Mohr, Sandeep Dembla, Manuela Schmidt, Bernd Nürnberg, Stephan E. Philipp, Michael G. Leitner, Marc Behrendt
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically available. Their action includes a strong central component, which also causes important adverse effects. However, µORs are also found on the peripheral endi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2258301f97517d5ddb60189fb377489
https://elifesciences.org/articles/26280
https://elifesciences.org/articles/26280