Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sandeep Burudkar"'
Publikováno v:
Journal of the Serbian Chemical Society, Vol 69, Iss 7, Pp 527-532 (2004)
3-Methoxy-5-nitrobenzaldehyde undergoes Knoevenagel reaction with malonic acid to give 3-methoxy-5-nitrocinnamic acid (I). Treatment of I with thionyl chloride yielded 3-chloro-5-methoxy-7-nitrobenzo[b]thiophene-2-carbonyl chloride (II) in 45 % yield
Externí odkaz:
https://doaj.org/article/35ad99eac10f4ca6a46eef34c4c54ee1
Autor:
Usha Ghosh, Smriti Khanna, Asha Kulkarni-Almeida, Ankita Srivastava, Komal Bajaj, Chandrika B-Rao, Prashant Tannu, Ashish P. Keche, Kumar V.S. Nemmani, Pranay Shah, Sandeep Burudkar, Rajiv Sharma, Yogesh Suresh Ahire, H. Sivaramakrishnan, Amol Dixit, Anagha Damre, Nitin J. Deshmukh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:834-838
We report our attempts at improving the oral efficacy of low-nanomolar inhibitors of xanthine oxidase from isocytosine series through chemical modifications. Our lead compound had earlier shown good in vivo efficacy when administered intraperitoneall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866072cdc89ac5f3a8aa3b0daba5e338
https://doi.org/10.1016/j.bmcl.2012.11.057
https://doi.org/10.1016/j.bmcl.2012.11.057
Publikováno v:
Journal of the Serbian Chemical Society, Vol 69, Iss 7, Pp 527-532 (2004)
3-Methoxy-5-nitrobenzaldehyde undergoes Knoevenagel reaction with malonic acid to give 3-methoxy-5-nitrocinnamic acid (I). Treatment of I with thionyl chloride yielded 3-chloro-5-methoxy-7-nitrobenzo[b]thiophene-2-carbonyl chloride (II) in 45 % yield
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2aac257cc03914e610b4b3623e8858
http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390407527H.pdf
http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390407527H.pdf
Autor:
Komal Bajaj, Lalit S. Doshi, Rajiv Sharma, Prashant Tannu, Ankita Srivastava, Nitin J. Deshmukh, Manoja K. Brahma, Avani Desai, Anagha Damre, Smriti Khanna, Sandeep Burudkar, Asha Kulkarni-Almeida, Pranay Shah, Usha Ghosh, Chandrika B-Rao, Ashish P. Keche, Amol Dixit, Kumar V.S. Nemmani, Umakant Ashok Bahirat, H. Sivaramakrishnan
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
Structure-activity relationship studies were carried out for lead generation following structure-guided design approach from an isocytosine scaffold identified earlier for xanthine oxidase inhibition. A 470-fold improvement in in vitro IC(50) was obt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffce995a86667308764db679b25321b
https://pubmed.ncbi.nlm.nih.gov/23122864
https://pubmed.ncbi.nlm.nih.gov/23122864