Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sandeep, Somani"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Publikováno v:
Journal of Chemical Information and Modeling. 63:2857-2865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f1ae9fbbba6a2937bb1b21310525f2d
https://doi.org/10.1021/acs.jcim.3c00243
https://doi.org/10.1021/acs.jcim.3c00243
Autor:
Aran F. Labrijn, Joyce I. Meesters, Matthew Bunce, Anthony A. Armstrong, Sandeep Somani, Tom C. Nesspor, Mark L. Chiu, Işil Altintaş, Sandra Verploegen, Janine Schuurman, Paul W. H. I. Parren
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Therapeutic concepts exploiting tumor-specific antibodies are often established in pre-clinical xenograft models using immuno-deficient mice. More complex therapeutic paradigms, however, warrant the use of immuno-competent mice, that more ac
Externí odkaz:
https://doaj.org/article/bbef8d706f08451bb51dc1be0939cbc2
Autor:
Christopher Negron, Wenting Ma, Alexey Teplyakov, Winnie Chan, Sandeep Somani, Thomas J. Malia, Lauren E. Boucher, Gary L. Gilliland, Jinquan Luo, Galina Obmolova, Steven Jacobs
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 90:270-281
This study uses differential scanning calorimetry, X-ray crystallography and molecular dynamics simulations to investigate the structural basis for the high thermal stability (melting temperature 97.5 °C) of a FN3-like protein domain from thermophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee132e201b802ca70f181b7d191acbf
https://doi.org/10.1002/prot.26218
https://doi.org/10.1002/prot.26218
Autor:
Renuka Thirumangalathu, Vineet Kumar, Sandeep Somani, Danika Rodrigues, Laura M. Tanenbaum, Kai Zhang, Santosh V. Thakkar, Ketan Amin
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1077-1082
Developing ultra-high concentration biotherapeutics drug products can be challenging due to increased viscosity, processing, and stability issues. Excipients used to alleviate these concerns are traditionally evaluated at lower protein concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accc1180e9cf7d818479b91b63354427
https://doi.org/10.1016/j.xphs.2020.12.016
https://doi.org/10.1016/j.xphs.2020.12.016
Autor:
Sriram Padmanabhan, Shweta Jain, Veena P. Raiker, Sandeep Somani, Rahul Nair, Nivedita Shekhar, Karpagavalli Damodaran, Sampali Banerjee, Krishna M.P. Das
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 3, Pp 2064-2076 (2011)
Expression of human granulocyte macrophage colony stimulating factor (hGMCSF), a cytokine of therapeutic importance, as a thioredoxin (TRX) fusion has been investigated in Escherichia coli BL21 (DE3) codon plus cells. The expression of this protein w
Externí odkaz:
https://doaj.org/article/e36b5da66b674b56a06a511bda38e6c2
Autor:
Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani, Sheng-Jiun Wu, Xuesong Liu, Alexis Gervais, Robin Ernst, Dorina Saro, Rose Decker, Jinquan Luo, Gary L. Gilliland, Mark L. Chiu, Bernard J. Scallon
Publikováno v:
Antibodies, Vol 6, Iss 3, p 12 (2017)
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamm
Externí odkaz:
https://doaj.org/article/e4effcd57176409f88ce8c9b266a42aa
Autor:
Santosh V. Thakkar, Danika Rodrigues, Bo Zhai, Dwaine Banton, Sandeep Somani, Alex Javidi, Andrew Mahan, Stuart Ember, Dominick DeGrazio, Subinay Ganguly, Ketan Amin, Hirsh Nanda
Publikováno v:
Journal of pharmaceutical sciences.
The rational design and selection of formulation composition to meet molecule-specific and product-specific needs are critical for biotherapeutics development to ensure physical and chemical stability. This work, based on three antibody-based (mAb) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82868a3378cdaad24636527f8bb1c1cf
https://pubmed.ncbi.nlm.nih.gov/36130676
https://pubmed.ncbi.nlm.nih.gov/36130676
Publikováno v:
Mol Pharm
Protein therapeutics typically require a concentrated protein formulation, which can lead to self-association and/or high viscosity due to protein-protein interaction (PPI). Excipients are often added to improve stability, bioavailability, and manufa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d5f702aa0e4d08d273fda577d01723
https://pubmed.ncbi.nlm.nih.gov/32965126
https://pubmed.ncbi.nlm.nih.gov/32965126
Autor:
Ketan Amin, Laura M. Tanenbaum, Renuka Thirumangalathu, Alexander D. MacKerell, Sunhwan Jo, Sandeep Somani, Danika Rodrigues, Santosh V. Thakkar
Publikováno v:
J Pharm Sci
Formulation of protein-based therapeutics employ advanced formulation and analytical technologies for screening various parameters such as buffer, pH, and excipients. At a molecular level, physico-chemical properties of a protein formulation depend o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac1b38b467fd67c09f84a2e296b6d16
https://pubmed.ncbi.nlm.nih.gov/33137372
https://pubmed.ncbi.nlm.nih.gov/33137372