Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Sandaruwan Geeganage"'
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
The concentrations of LSN3154567 in the dog plasma samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e6822518f21d94bca7c1d9980cb9dc
https://doi.org/10.1158/1535-7163.22510030.v1
https://doi.org/10.1158/1535-7163.22510030.v1
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aee608d35f9d18aa0d631046f9435f6
https://doi.org/10.1158/1535-7163.c.6539479
https://doi.org/10.1158/1535-7163.c.6539479
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
Table S1: anti-proliferative activity of LSN3154567 against different cancer cell lines; Table S2: effects of NAM on the anti-proliferative activity of LSN3154567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f70612a84c12c12c5e1209c6248e3b6
https://doi.org/10.1158/1535-7163.22510024
https://doi.org/10.1158/1535-7163.22510024
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Supplementary Figure Legends & Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057a178b991babc2517ecf5b994d7838
https://doi.org/10.1158/1078-0432.22471418.v1
https://doi.org/10.1158/1078-0432.22471418.v1
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Figure S1. Efficacy of pemetrexed in Lewis Lung carcinoma model and metabolomic analysis of MC38 tumor bearing mice treated with 50 mg/kg of pemetrexed Figure S2. T cell inflamed phenotype induced by pemetrexed is modestly reduced in tumors upon comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf5c80af2bf8dacf087ab7a6132752
https://doi.org/10.1158/1078-0432.22471421
https://doi.org/10.1158/1078-0432.22471421
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Purpose:Combination strategies leveraging chemotherapeutic agents and immunotherapy have held the promise as a method to improve benefit for patients with cancer. However, most chemotherapies have detrimental effects on immune homeostasis and differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55d83fcda2c247c186c9439427cc003
https://doi.org/10.1158/1078-0432.c.6527882.v1
https://doi.org/10.1158/1078-0432.c.6527882.v1
Autor:
Laura E. Benjamin, Sandaruwan Geeganage, Dina Lev, Marcelo L. Hochman, Ladan Enayati, Paul Rodriguez-Waitkus, Rajesh Ramanna-Valmiki, Isabel Acevedo, Carole A. Perruzzi, Sokha Nhek, Zeus Antonello, Damien Gerald, Sriram Ayyaswamy, Qi Xue, Wa Du, Thuy L. Phung
Vascular tumors are endothelial cell neoplasms whose mechanisms of tumorigenesis are poorly understood. Moreover, current therapies, particularly those for malignant lesions, have little beneficial effect on clinical outcomes. In this study, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6df64b26bba8a45b1e3f9bc3b082faf
https://doi.org/10.1158/0008-5472.c.6505943
https://doi.org/10.1158/0008-5472.c.6505943
Autor:
Laura E. Benjamin, Sandaruwan Geeganage, Dina Lev, Marcelo L. Hochman, Ladan Enayati, Paul Rodriguez-Waitkus, Rajesh Ramanna-Valmiki, Isabel Acevedo, Carole A. Perruzzi, Sokha Nhek, Zeus Antonello, Damien Gerald, Sriram Ayyaswamy, Qi Xue, Wa Du, Thuy L. Phung
Supplementary Figure S1. Phosphorylated-Akt staining in human vascular tumors. Immunohistochemical stains for phospho-Akt (S473) in normal human skin and human vascular tumors. Representative areas of "low" and "high" levels of staining within a tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97aa2608be9148984985447caadfb1de
https://doi.org/10.1158/0008-5472.22401908
https://doi.org/10.1158/0008-5472.22401908
Autor:
Harold B. Brooks, Shuang Luo, Timothy I. Meier, Kwame Frimpong, Timothy B. Durham, Matthew Lee, Kevin Robert Fales, Kenneth Jeff Thrasher, Philip W. Iversen, Robert T. Foreman, Yu-Hua Hui, Charles D. Spencer, Sandaruwan Geeganage, Kenneth D. Roth, Alicia Torrado, Yong Wang, Chong Si, Jefferson R. Mc Cowan, Stefan Jon Thibodeaux, Zhipei Wu, Timothy Alan Shepherd, James Lee Toth, Tao Wang, Yue-Wei Qian, Robert Dean Dally, Njoroge F George, Susan A. Konicek
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
AICARFT is a folate dependent catalytic site within the ATIC gene, part of the purine biosynthetic pathway, a pathway frequently upregulated in cancers. LSN3213128 is a potent (16 nM) anti-folate inhibitor of AICARFT and selective relative to TS, SHM
Autor:
Anna M. Szpurka, Sandaruwan Geeganage, Johanna C. Bendell, Johan Wallin, Shadia I. Jalal, Sylvie Rottey, Karim A. Benhadji, Hans Prenen, Leena Gandhi, Thompson N. Doman, Violeta Regnier Galvao, Nuria Kotecki, Subha Suriyapperuma, Meng Xia, Abhijoy Saha, P. Vuagnat, Xiaojian Xu, Bert H. O'Neil
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997)
LY3381916 is an orally available, highly selective, potent inhibitor of indoleamine 2,3-dioxygenase 1. This study explored the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of LY3381916 monotherapy and in combinatio