Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations

Autor: Cismaru, Anca Liliana, Rudin, Deborah, Ibañez, Luisa, Liakoni, Evangelia, Bonadies, Nicolas, Kreutz, Reinhold, Carvajal, Alfonso, Lucena, Maria Isabel, Martin, Javier, Sancho Ponce, Esther, Molokhia, Mariam, Eriksson, Niclas, Krähenbühl, Stephan, Largiadèr, Carlo R., Haschke, Manuel, Hallberg, Pär, Wadelius, Mia, Universitat Autònoma de Barcelona

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic widely used in countries such as Switzerland and Germany. Notably, an underlying mechanism has not yet been fully elucidated and no predictive factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f9b616ce5a976e8e0d734b1561648f51
https://ddd.uab.cat/record/253047

Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus

Autor: Wadelius, Mia, Eriksson, Niclas, Kreutz, Reinhold, Bondon-Guitton, Emmanuelle, Ibáñez, Luisa, Carvajal, Alfonso, Lucena, M. Isabel, Sancho Ponce, Esther, Molokhia, Mariam, Martin Martinez, Javier, Axelsson, Tomas, Kohnke, Hugo, Yue, Qun-Ying, Magnusson, Patrik K. E., Bengtsson, Mats, Hallberg, Pär, Universitat Autònoma de Barcelona

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. We performed a genome-wide association study comprising 9,380,034 polymorphisms and 180 HLA alleles in 36 cas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::844383489d8fb8a52b8363ce2ed99349
Wiley Online Library

Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations.

Autor: Cismaru AL; Department of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland., Rudin D; Department of Clinical Pharmacology & Toxicology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.; Department of Biomedicine, University of Basel, 4051 Basel, Switzerland., Ibañez L; Clinical Pharmacology Service, Hospital Universitari Vall d'Hebron, Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Fundació Institut Català de Farmacología, 08035 Barcelona, Spain., Liakoni E; Department of Clinical Pharmacology & Toxicology, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.; Institute of Pharmacology, University of Bern, 3012 Bern, Switzerland., Bonadies N; Department of Hematology and Central Hematology Laboratory, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland., Kreutz R; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Klinische Pharmakologie und Toxikologie, 10117 Berlin, Germany., Carvajal A; Centro de Estudios sobre la Seguridad de los Medicamentos, Universidad de Valladolid, 47005 Valladolid, Spain., Lucena MI; Servicio Farmacologia Clinica, Instituto de Investigación Biomedica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, 29010 Málaga, Spain., Martin J; Instituto de Parasitología y Biomedicina Lopez-Neyra, Consejo Superior de Investigaciones Cientiíficas, 18016 Granada, Spain., Sancho Ponce E; Servei d'Hematologia i Banc de Sang, Hospital General de Catalunya, 08190 Sant Cugat del Vallès, Spain., Molokhia M; Department of Population Health Sciences, King's College London, London WC2R 2LS, UK., Eriksson N; Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden., EuDAC Collaborators, Krähenbühl S; Department of Clinical Pharmacology & Toxicology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland., Largiadèr CR; Department of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland., Haschke M; Department of Clinical Pharmacology & Toxicology, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.; Institute of Pharmacology, University of Bern, 3012 Bern, Switzerland., Hallberg P; Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden., Wadelius M; Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden., Amstutz U; Department of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Publikováno v: Genes [Genes (Basel)] 2020 Oct 29; Vol. 11 (11). Date of Electronic Publication: 2020 Oct 29.