Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Sanchita P Ghosh"'
Autor:
Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, Kosaku Shinoda, Gary Eichenbaum, Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette, Chandan Guha
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating regeneration of the bone marrow (BM), namely the hematopoietic stem and progeni
Externí odkaz:
https://doaj.org/article/2bf07de7fabd40f4808a08994b77ce37
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122258 (2015)
We reported that microRNA-30c (miR-30c) plays a key role in radiation-induced human cell damage through an apoptotic pathway. Herein we further evaluated radiation-induced miR-30 expression and mechanisms of delta-tocotrienol (DT3), a radiation count
Externí odkaz:
https://doaj.org/article/7993b844ba9043078716cd0015b4878d
Autor:
Rupak Pathak, Lijian Shao, Sanchita P Ghosh, Daohong Zhou, Marjan Boerma, Hartmut Weiler, Martin Hauer-Jensen
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122511 (2015)
Systemic administration of recombinant thrombomodulin (TM) confers radiation protection partly by accelerating hematopoietic recovery. The uniquely potent radioprotector gamma tocotrienol (GT3), in addition to being a strong antioxidant, inhibits the
Externí odkaz:
https://doaj.org/article/85a219baf58e46818b8638259a3697a4
Autor:
Nabarun Chakraborty, Allison Hoke, Ross Campbell, Gregory Holmes-Hampton, Vidya P. Kumar, Candace Moyler, Aarti Gautam, Rasha Hammamieh, Sanchita P. Ghosh
Publikováno v:
Microorganisms, Vol 12, Iss 10, p 1995 (2024)
Microorganisms that colonize in or on a host play significant roles in regulating the host’s immunological fitness and bioenergy production, thus controlling the host’s stress responses. Radiation elicits a pro-inflammatory and bioenergy-expensiv
Externí odkaz:
https://doaj.org/article/4fe48d5e969f44fd8bf9652b7c8c21bb
Autor:
Nabarun Chakraborty, Gregory P. Holmes-Hampton, Aarti Gautam, Raina Kumar, Bernadette Hritzo, Betre Legesse, George Dimitrov, Sanchita P. Ghosh, Rasha Hammamieh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Early diagnosis of lethal radiation is imperative since its intervention time windows are considerably short. Hence, ideal diagnostic candidates of radiation should be easily accessible, enable to inform about the stress history and objectiv
Externí odkaz:
https://doaj.org/article/c1e8a554e4ad4255b7c111678054369e
Autor:
Gregory P. Holmes-Hampton, Vidya P. Kumar, Shukla Biswas, Sasha Stone, Neel K. Sharma, Betre Legesse, Justin Vercellino, Chandan Guha, Gary Eichenbaum, Sanchita P. Ghosh
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Thrombopoietin (TPO) is the primary regulator of platelet generation and a stimulator of multilineage hematopoietic recovery following exposure to total body irradiation (TBI). JNJ‑26366821, a novel PEGylated TPO mimetic peptide, stimulate
Externí odkaz:
https://doaj.org/article/29ff676478dc4f61943029825ec72491
Publikováno v:
eXPRESS Polymer Letters, Vol 17, Iss 6, Pp 610-624 (2023)
A biomimetic strategy was adopted by incorporating nano-fluorcanasite (nFC) within biocompatible and biodegradable poly-(ε-caprolactone) (PCL) matrix to obtain functionally tuned bio-nanocomposite bone scaffolds. A hybrid approach was adopted using
Externí odkaz:
https://doaj.org/article/c4cbc2795fa940918d46f38b364d5326
Time- and sex-dependent delayed effects of acute radiation exposure manifest via miRNA dysregulation
Autor:
Gregory P. Holmes-Hampton, Dharmendra Kumar Soni, Vidya P. Kumar, Shukla Biswas, Kefale Wuddie, Roopa Biswas, Sanchita P. Ghosh
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108867- (2024)
Summary: The detrimental effects of high-dose ionizing radiation on human health are well-known, but the influence of sex differences on the delayed effects of acute radiation exposure (DEARE) remains unclear. Here, we conducted six-month animal expe
Externí odkaz:
https://doaj.org/article/98aa12822cf64f47b756f591c754047f
Autor:
Dharmendra Kumar Soni, Vidya P. Kumar, Shukla Biswas, Gregory P. Holmes-Hampton, Sharmistha Bhattacharyya, Lawrence J. Thomas, Roopa Biswas, Sanchita P. Ghosh
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 569-584 (2022)
Risks of radiation exposure necessitate the development of radioprophylactic drugs. We have reported the efficacy of CDX-301, a recombinantly developed human protein form of Fms-related tyrosine kinase 3 ligand (Flt3L), as a radioprophylactic and rad
Externí odkaz:
https://doaj.org/article/a9d69ae6fab54273a63cbf87c390239d
Autor:
Vidya P. Kumar, Gregory P. Holmes-Hampton, Shukla Biswas, Sasha Stone, Neel Kamal Sharma, Bernadette Hritzo, Mary Guilfoyle, Gary Eichenbaum, Chandan Guha, Sanchita P. Ghosh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The threat of a nuclear attack has increased in recent years highlighting the benefit of developing additional therapies for the treatment of victims suffering from Acute Radiation Syndrome (ARS). In this work, we evaluated the impact of a P
Externí odkaz:
https://doaj.org/article/8db84f097dc24630a7483f88f2f010e1