GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.

Autor: Quarta C; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; University of Bordeaux, INSERM, Neurocentre Magendie, Bordeaux, France., Stemmer K; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Molecular Cell Biology, Institute for Theoretical Medicine, University of Augsburg, Augsburg, Germany., Novikoff A; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Division of Metabolic Diseases, Department of Medicine, Technical University of München, Munich, Germany., Yang B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Klingelhuber F; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Harger A; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bakhti M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany., Bastidas-Ponce A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany., Baugé E; Inserm, CHU Lille, Institute of Pasteur de Lille, European Genomic Institute for Genomics, University of Lille, Lille, France., Campbell JE; Department of Medicine, Division of Endocrinology, Duke University, Durham, NC, USA., Capozzi M; Department of Medicine, Division of Endocrinology, Duke University, Durham, NC, USA., Clemmensen C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Collden G; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Cota P; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany., Douros J; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Drucker DJ; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada., DuBois B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Feuchtinger A; Research Unit Analytical Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Garcia-Caceres C; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grandl G; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hennuyer N; Inserm, CHU Lille, Institute of Pasteur de Lille, European Genomic Institute for Genomics, University of Lille, Lille, France., Herzig S; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Center Munich, Neuherberg, Germany., Hofmann SM; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.; Medical Clinic and Polyclinic IV, Ludwig-Maximilians University of München, Munich, Germany., Knerr PJ; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA., Kulaj K; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Lalloyer F; Inserm, CHU Lille, Institute of Pasteur de Lille, European Genomic Institute for Genomics, University of Lille, Lille, France., Lickert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany., Liskiewicz A; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Liskiewicz D; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Maity G; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Perez-Tilve D; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Prakash S; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Sanchez-Garrido MA; Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Córdoba, Córdoba, Spain., Zhang Q; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Staels B; Inserm, CHU Lille, Institute of Pasteur de Lille, European Genomic Institute for Genomics, University of Lille, Lille, France., Krahmer N; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., DiMarchi RD; Department of Chemistry, Indiana University, Bloomington, IN, USA., Tschöp MH; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Division of Metabolic Diseases, Department of Medicine, Technical University of München, Munich, Germany.; Helmholtz Zentrum München, Neuherberg, Germany., Finan B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA. BFIN@novonordisk.com., Müller TD; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany. timo.mueller@helmholtz-muenchen.de.; German Center for Diabetes Research (DZD), Neuherberg, Germany. timo.mueller@helmholtz-muenchen.de.

Publikováno v: Nature metabolism [Nat Metab] 2022 Aug; Vol. 4 (8), pp. 1071-1083. Date of Electronic Publication: 2022 Aug 22.

Neonatal exposure to androgens dynamically alters gut microbiota architecture.

Autor: Barroso A; Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain.; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain., Santos-Marcos JA; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain., Perdices-Lopez C; Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain.; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain., Vega-Rojas A; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain., Sanchez-Garrido MA; Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain.; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain., Krylova Y; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain., Molina-Abril H; Department of Applied Mathematics I, University of Seville, Seville, Spain., Ohlsson C; Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Perez-Martinez P; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain., Poutanen M; Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland., Lopez-Miranda J; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain., Tena-Sempere M; Department of Cell Biology, Physiology, and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain.; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland., Camargo A; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.; Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.

Publikováno v: The Journal of endocrinology [J Endocrinol] 2020 Oct; Vol. 247 (1), pp. 69-85.

Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.

Autor: Sanchez-Garrido MA; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Spain; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Spain; Hospital Universitario Reina Sofia, Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III Cordoba, Spain. Electronic address: b12sanom@uco.es., Tena-Sempere M; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Spain; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Spain; Hospital Universitario Reina Sofia, Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III Cordoba, Spain; FiDiPro Program, Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland.

Publikováno v: Molecular metabolism [Mol Metab] 2020 May; Vol. 35, pp. 100937. Date of Electronic Publication: 2020 Feb 05.

Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice.

Autor: Leon S; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Velasco I; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Vázquez MJ; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Barroso A; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Beiroa D; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain; Department of Physiology, Faculty of Medicine and CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain., Heras V; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Ruiz-Pino F; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Manfredi-Lozano M; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Romero-Ruiz A; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Sanchez-Garrido MA; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Dieguez C; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain; Department of Physiology, Faculty of Medicine and CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain., Pinilla L; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Roa J; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain., Nogueiras R; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain; Department of Physiology, Faculty of Medicine and CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain., Tena-Sempere M; Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), University of Cordoba, 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, Instituto de Salud Carlos III, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain; FiDiPro Program, Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address: fi1tesem@uco.es.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2018 Oct; Vol. 87, pp. 87-97. Date of Electronic Publication: 2018 Jul 31.

Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty.

Autor: Manfredi-Lozano M; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofia (HURS), 14004 Córdoba, Spain., Roa J; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofia (HURS), 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Córdoba, Spain. Electronic address: roarivas@gmail.com., Ruiz-Pino F; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofia (HURS), 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Córdoba, Spain., Piet R; Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, 9054 Dunedin, New Zealand., Garcia-Galiano D; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain., Pineda R; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain., Zamora A; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain., Leon S; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain., Sanchez-Garrido MA; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Córdoba, Spain., Romero-Ruiz A; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain., Dieguez C; Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela 15782, Spain., Vazquez MJ; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofia (HURS), 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Córdoba, Spain., Herbison AE; Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, 9054 Dunedin, New Zealand., Pinilla L; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofia (HURS), 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Córdoba, Spain., Tena-Sempere M; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofia (HURS), 14004 Córdoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Córdoba, Spain. Electronic address: fi1tesem@uco.es.

Publikováno v: Molecular metabolism [Mol Metab] 2016 Aug 11; Vol. 5 (10), pp. 844-857. Date of Electronic Publication: 2016 Aug 11 (Print Publication: 2016).