Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC registry

Autor: Zapata-Wainberg, G, Quintas, S, Rico, AX, Fernandez, LB, Vallejo, JM, Cullere, JG, Guerrero, MDF, Egido, J, Sanchez, JCG, Domeno, AM, Purroy, F, Pastor, BV, Yanez, MR, Vivancos, J

Publikováno v: NEUROLOGIA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Introduction: Intracranial haemorrhages (ICH) represent a severe and frequently lethal complication in patients treated with vitamin K antagonists (VKA). The purpose of our study is to describe the factors and clinical features associated with mortal

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Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.

Autor: Lopez C; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, 89081, Germany; Institute of Human Genetics, Christian-Albrechts-University, Kiel, 24105., Schleussner N; Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, 13125, Germany; Hematology, Oncology and Tumor Immunology, Charite - Universitatsmedizin Berlin, Berlin, 12200, Germany, and Experimental and Clinical Research Center, a joint cooperation between the MDC and the Charite, Berlin, 13125., Bernhart SH; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, 04107, Germany; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, 04107, Germany; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107., Kleinheinz K; Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, 69120., Sungalee S; EMBL Heidelberg, Genome Biology Unit, Heidelberg, 69117., Sczakiel HL; Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, 13125, Germany; Hematology, Oncology and Tumor Immunology, Charite - Universitatsmedizin Berlin, Berlin, 12200, Germany, and Experimental and Clinical Research Center, a joint cooperation between the MDC and the Charite, Berlin, 13125., Kretzmer H; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, 04107, Germany; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, 04107, Germany; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin., Toprak UH; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, 69120, Germany; Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Division of Neuroblastoma Genomics (B087, German Cancer Research Center (DKFZ), Heidelberg, 69120., Glaser S; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, 89081., Wagener R; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, 89081, Germany; Institute of Human Genetics, Christian-Albrechts-University, Kiel, 24105., Ammerpohl O; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, 89081, Germany; Institute of Human Genetics, Christian-Albrechts-University, Kiel, 24105., Bens S; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, 89081, Germany; Institute of Human Genetics, Christian-Albrechts-University, Kiel, 24105., Giefing M; Institute of Human Genetics, Christian-Albrechts-University, Kiel, 24105, Germany; Institute of Human Genetics, Polish Academy of Sciences, Poznan, 60-479, Poland., Sanchez JCG; BioQuant and Biochemie Zentrum Heidelberg (BZH), Heidelberg University, Heidelberg, 69120., Apic G; BioQuant and Biochemie Zentrum Heidelberg (BZH), Heidelberg University, Heidelberg, 69120., Hubschmann D; German Cancer Consortium (DKTK), Heidelberg, 69120, Germany; Heidelberg Institute of Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, 69120, Germany; Computational Oncology, Molecular Precision Oncology Program, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, 69120., Janz M; Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, 13125, Germany; Hematology, Oncology and Tumor Immunology, Charite - Universitatsmedizin Berlin, Berlin, 12200, Germany, and Experimental and Clinical Research Center, a joint cooperation between the MDC and the Charite, Berlin, 13125., Kreuz M; Institute for Medical Informatics Statistics and Epidemiology, Leipzig, 04107., Mottok A; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, 89081., Muller JM; Klinik für Urologie und Zentrale Klinische Forschung, Klinikum der Albert-Ludwigs-Universitat Freiburg, Freiburg, 79104., Seufert J; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, 69120., Hoffmann S; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, 04107, Germany; Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, 04107, Germany; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany; Leibniz Institute on Ageing-Fritz Lipmann Institute (FLI), Computational Biology, Jena, 07745., Korbel JO; EMBL Heidelberg, Genome Biology Unit, Heidelberg, 69117., Russell RB; BioQuant and Biochemie Zentrum Heidelberg (BZH), Heidelberg University, Heidelberg, 69120., Schule R; Klinik für Urologie und Zentrale Klinische Forschung, Klinikum der Albert-Ludwigs-Universitat Freiburg, Freiburg, 79104, Germany; BIOSS Centre of Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Freiburg, 79104., Trumper L; Department of Hematology and Oncology, Georg-August-University of Gottingen, Gottingen, 37075., Klapper W; Hematopathology Section, Christian-Albrechts-University, Kiel, 24105., Radlwimmer B; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg., Lichter P; Division of Molecular Genetics, German Cancer Research Center (DKFZ), 69120, Heidelberg., Kuppers R; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, 45147, Germany, and German Cancer Consortium (DKTK)., Schlesner M; Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; Biomedical Informatics, Data Mining and Data Analytics, Augsburg University, Augsburg, 86159., Mathas S; Max-Delbruck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, 13125, Germany; Hematology, Oncology and Tumor Immunology, Charite - Universitatsmedizin Berlin, Berlin, 12200, Germany, and Experimental and Clinical Research Center, a joint cooperation between the MDC and the Charite, Berlin, 13125., Siebert R; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, 89081, Germany; Institute of Human Genetics, Christian-Albrechts-University, Kiel, 24105.

Publikováno v: Haematologica [Haematologica] 2023 Feb 01; Vol. 108 (2), pp. 543-554. Date of Electronic Publication: 2023 Feb 01.