Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sanchaika Gaur"'
Autor:
Matthew J Schiewer, Amy C Mandigo, Nicolas Gordon, Fangjin Huang, Sanchaika Gaur, Renée deLeeuw, Shuang G Zhao, Joseph Evans, Sumin Han, Theodore Parsons, Ruth Birbe, Peter McCue, Christopher McNair, Saswati N Chand, Ylenia Cendon‐Florez, Peter Gallagher, Jennifer J McCann, Neermala Poudel Neupane, Ayesha A Shafi, Emanuela Dylgjeri, Lucas J Brand, Tapio Visakorpi, Ganesh V Raj, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Adam P Dicker, Wm. Kevin Kelly, Benjamin E Leiby, Beatrice Knudsen, Felix Y Feng, Karen E Knudsen
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp n/a-n/a (2018)
Abstract PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of P
Externí odkaz:
https://doaj.org/article/044d966fd25b4793a1abaa4247be3583
Autor:
Gary E. Gallick, Christopher J. Logothetis, Sue-Hwa Lin, Mian Alauddin, Yiping Shao, Bogdan A. Czerniak, Menashe Bar Eli, Sankar N. Maity, Lynnelle Thorpe, Sanchaika Gaur, Anh G. Hoang, Ana Aparicio, Yu-Chen Lee, Jian H. Song, Eleni Efstathiou, Nila U. Parikh, Paul G. Corn, Andreas Varkaris
Supplemental Figure 1 (fig. S1). Representative whole body NaF-18 PET scan images after 44 days of (A) vehicle-treated and (B) cabozantinib-treated animals. Supplemental Figure 2 (fig. S2). Effect of cabozantinib on PDX tumor growth, animal weight, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1771a12684127acc4701f3e4133b4f8d
https://doi.org/10.1158/1078-0432.22461362
https://doi.org/10.1158/1078-0432.22461362
Autor:
Gary E. Gallick, Christopher J. Logothetis, Sue-Hwa Lin, Mian Alauddin, Yiping Shao, Bogdan A. Czerniak, Menashe Bar Eli, Sankar N. Maity, Lynnelle Thorpe, Sanchaika Gaur, Anh G. Hoang, Ana Aparicio, Yu-Chen Lee, Jian H. Song, Eleni Efstathiou, Nila U. Parikh, Paul G. Corn, Andreas Varkaris
Purpose: We performed parallel investigations in cabozantinib-treated patients in a phase II trial and simultaneously in patient-derived xenograft (PDX) models to better understand the roles of MET and VEGFR2 as targets for prostate cancer therapy.Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f627afa09d75e41a7e6ac87ed12b9c4
https://doi.org/10.1158/1078-0432.c.6524774
https://doi.org/10.1158/1078-0432.c.6524774
Autor:
Gary E. Gallick, Christopher J. Logothetis, Sue-Hwa Lin, Mian Alauddin, Yiping Shao, Bogdan A. Czerniak, Menashe Bar Eli, Sankar N. Maity, Lynnelle Thorpe, Sanchaika Gaur, Anh G. Hoang, Ana Aparicio, Yu-Chen Lee, Jian H. Song, Eleni Efstathiou, Nila U. Parikh, Paul G. Corn, Andreas Varkaris
supplementary materials and methods, supplementary tables and supplementary figure legends Supplemental Table 1: Patient Characteristics. Supplemental Table 2: Targeting sequences for c-met. Supplemental Table 3: Antibodies and Sources. Supplemental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22eaeb0f86f14ce9b6ab154dcb5972a4
https://doi.org/10.1158/1078-0432.22461359
https://doi.org/10.1158/1078-0432.22461359
Autor:
Ylenia Cendon-Florez, Edouard J. Trabulsi, Neermala Poudel Neupane, Benjamin E. Leiby, Felix Y. Feng, Saswati N. Chand, Sumin Han, Matthew J. Schiewer, Sanchaika Gaur, Christopher McNair, Lucas J. Brand, Shuang G. Zhao, Amy C. Mandigo, Emanuela Dylgjeri, Peter A. McCue, Ayesha A. Shafi, Ganesh V. Raj, Renée de Leeuw, Beatrice S. Knudsen, Karen E. Knudsen, Costas D. Lallas, Tapio Visakorpi, Nicolas Gordon, Theodore Parsons, Leonard G. Gomella, Peter Gallagher, Ruth Birbe, Wm. Kevin Kelly, Jennifer J. McCann, Fangjin Huang, Joseph R. Evans, Adam P. Dicker
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp n/a-n/a (2018)
EMBO Molecular Medicine
EMBO Molecular Medicine
PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP‐1 e
Autor:
Sanchaika Gaur, Christopher J. Logothetis, Gary E. Gallick, Andreas Varkaris, Jung-Kang Jin, Nila U. Parikh, Farshid Dayyani, Jian H. Song
Publikováno v:
International Journal of Cancer. 133:1536-1546
The receptor tyrosine kinase, MET, has been implicated in tumorigenesis and metastasis of many solid tumors, by multiple mechanisms, including cross talk with epidermal growth factor receptor. In this study, we examined the role of insulin-like growt
Autor:
Gary E. Gallick, Paul G. Corn, Sanchaika Gaur, Farshid Dayyani, Christopher J. Logothetis, Andreas Varkaris
Publikováno v:
Expert Opinion on Investigational Drugs. 20:1677-1684
An increasing number of basic, translational and clinical studies demonstrate the importance of the protein tyrosine kinase receptor, c-Met, in the progression of prostate cancer. c-Met is overexpressed in primary prostate cancers, further increased
Autor:
Mark A. Rubin, Edouard J. Trabulsi, Tapio Visakorpi, Wm. Kevin Kelly, Theodore Parsons, Johann S. de Bono, Nicolas Gordon, Ruth Birbe, Matthew J. Schiewer, Peter McCue, Ganesh V. Raj, George Zhao, Leonard G. Gomella, Fangjin Huang, Karen E. Knudsen, Costas D. Lallas, Felix Y. Feng, Sumin Han, Adam P. Dicker, Amy C. Mandigo, Joseph L. Evans, Sanchaika Gaur, Beatrice S. Knudsen
Publikováno v:
Cancer Research. 78:B017-B017
PARP-1 holds at least four major functions on chromatin: DNA damage repair, telomeric maintenance, chromatin dynamics, and transcriptional regulation—all of which are relevant in the context of cancer. Notably, PARP-1 has been found to be a key mod
Autor:
Anil K. Sood, Yan Shi, Daniel E. Frigo, Cristina Ivan, Nila U. Parikh, Sanchaika Gaur, Yunfei Wen, Alicia M. Blessing, Lingegowda S. Mangala, Gabriel Lopez-Berestein, Andreas Varkaris, Jian H. Song, Gary E. Gallick, Sherry Y. Wu
Publikováno v:
Oncotarget
While several new therapies are FDA-approved for bone-metastatic prostate cancer (PCa), patient survival has only improved marginally. Here, we report that chitosan nanoparticle-mediated delivery of miR-34a, a tumor suppressive microRNA that downregu
Abstract LB-086: PARP-1 controls the DNA damage response by regulating E2F1 transcriptional activity
Autor:
Ruth Birbe, Matthew J. Schiewer, Edouard J. Trabulsi, Peter McCue, Ganesh V. Raj, Sumin Han, Adam P. Dicker, Felix Y. Feng, Theodore Parsons, Fangjin Huang, Amy C. Mandigo, Nicolas Gordon, Joseph L. Evans, Sanchaika Gaur, Leonard G. Gomella, Karen E. Knudsen, Mark A. Rubin, Costas D. Lallas, Johann S. de Bono, Kevin R. Kelly, Beatrice S. Knudsen, Tapio Visakorpi, Shuang G. Zhao
Publikováno v:
Cancer Research. 77:LB-086
PARP-1 holds two major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Notably, PARP-1 has been found to be a key modulator of androgen receptor (AR) function and AR-depen