Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Sancha, Martin"'
Autor:
Arie B. Brinkman, Serena Nik-Zainal, Femke Simmer, F. Germán Rodríguez-González, Marcel Smid, Ludmil B. Alexandrov, Adam Butler, Sancha Martin, Helen Davies, Dominik Glodzik, Xueqing Zou, Manasa Ramakrishna, Johan Staaf, Markus Ringnér, Anieta Sieuwerts, Anthony Ferrari, Sandro Morganella, Thomas Fleischer, Vessela Kristensen, Marta Gut, Marc J. van de Vijver, Anne-Lise Børresen-Dale, Andrea L. Richardson, Gilles Thomas, Ivo G. Gut, John W. M. Martens, John A. Foekens, Michael R. Stratton, Hendrik G. Stunnenberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
In cancer, global DNA methylation loss and CpG island hypermethylation are commonly observed. Here, in breast cancer the authors find that hyper-variability of partially methylated domains is the prime source of DNA methylation variation and that the
Externí odkaz:
https://doaj.org/article/2a2b3c50b9604a109e1e00c8b53b792f
Autor:
Marie Horton, Parvati R. Perman-Howe, Colin Angus, Julie Bishop, Ilze Bogdanovica, Alan Brennan, John Britton, Leonie S. Brose, Jamie Brown, Jeff Collin, Martin Dockrell, Niamh Fitzgerald, Sharon Friel, Duncan Gillespie, Anna B. Gilmore, Sarah E. Hill, Cecile Knai, Tessa Langley, Sancha Martin, Ann McNeill, Graham Moore, Marcus R. Munafò, Rachael L. Murray, Magdelena Opazo Breton, Jamie Pearce, Mark Petticrew, Garth Reid, Deborah Robson, Harry Rutter, Lion Shahab, Niamh Shortt, Katherine Smith, Keith Syrett, Linda Bauld
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
The main causes of non-communicable diseases (NCDs), health inequalities and health inequity include consumption of unhealthy commodities such as tobacco, alcohol and/or foods high in fat, salt and/or sugar. These exposures are preventable, but the c
Externí odkaz:
https://doaj.org/article/e15b8b189a1e43d587144f7e9f909a28
Autor:
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profi
Externí odkaz:
https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f
Autor:
Iain A. McNeish, Andrew V. Biankin, David Millan, Sancha Martin, Philip Beer, Nafisa Wilkinson, Agata Kochman, Elizabeth Day, Sarah Bell, Naveena Singh, Rosalind M. Glasspool, Lynn Hirschowitz, James Paul, Mei Yen Chan, Suzanne Dowson, Lisa Evers, Darren Ennis, Susanna L. Cooke
A full list of mutations identified in SCC and MCT samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abfbf7e7b43fde3af8f1d5c581d9383
https://doi.org/10.1158/1078-0432.22463138.v1
https://doi.org/10.1158/1078-0432.22463138.v1
Autor:
Iain A. McNeish, Andrew V. Biankin, David Millan, Sancha Martin, Philip Beer, Nafisa Wilkinson, Agata Kochman, Elizabeth Day, Sarah Bell, Naveena Singh, Rosalind M. Glasspool, Lynn Hirschowitz, James Paul, Mei Yen Chan, Suzanne Dowson, Lisa Evers, Darren Ennis, Susanna L. Cooke
Kaplan Meier overall survival curves by PIK3CA, CDKN2A and TP53 allelic mutation state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d240b1ff3a1cd1e58a3da7b778e053e
https://doi.org/10.1158/1078-0432.22463159
https://doi.org/10.1158/1078-0432.22463159
Autor:
Iain A. McNeish, Andrew V. Biankin, David Millan, Sancha Martin, Philip Beer, Nafisa Wilkinson, Agata Kochman, Elizabeth Day, Sarah Bell, Naveena Singh, Rosalind M. Glasspool, Lynn Hirschowitz, James Paul, Mei Yen Chan, Suzanne Dowson, Lisa Evers, Darren Ennis, Susanna L. Cooke
Purpose: We sought to identify the genomic abnormalities in squamous cell carcinomas (SCC) arising in ovarian mature cystic teratoma (MCT), a rare gynecological malignancy of poor prognosis.Experimental design: We performed copy number, mutational st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c74226b420d122b79c4498d2f41a07
https://doi.org/10.1158/1078-0432.c.6525317
https://doi.org/10.1158/1078-0432.c.6525317
Autor:
Iain A. McNeish, Andrew V. Biankin, David Millan, Sancha Martin, Philip Beer, Nafisa Wilkinson, Agata Kochman, Elizabeth Day, Sarah Bell, Naveena Singh, Rosalind M. Glasspool, Lynn Hirschowitz, James Paul, Mei Yen Chan, Suzanne Dowson, Lisa Evers, Darren Ennis, Susanna L. Cooke
Supplementary Methods and legends for Supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab7e29c1681706b37ad024b15bb1dd9
https://doi.org/10.1158/1078-0432.22463150.v1
https://doi.org/10.1158/1078-0432.22463150.v1
Autor:
Marcel Smid, F. Germán Rodríguez-González, Anieta M. Sieuwerts, Roberto Salgado, Wendy J. C. Prager-Van der Smissen, Michelle van der Vlugt-Daane, Anne van Galen, Serena Nik-Zainal, Johan Staaf, Arie B. Brinkman, Marc J. van de Vijver, Andrea L. Richardson, Aquila Fatima, Kim Berentsen, Adam Butler, Sancha Martin, Helen R. Davies, Reno Debets, Marion E. Meijer-Van Gelder, Carolien H. M. van Deurzen, Gaëtan MacGrogan, Gert G. G. M. Van den Eynden, Colin Purdie, Alastair M. Thompson, Carlos Caldas, Paul N. Span, Peter T. Simpson, Sunil R. Lakhani, Steven Van Laere, Christine Desmedt, Markus Ringnér, Stefania Tommasi, Jorunn Eyford, Annegien Broeks, Anne Vincent-Salomon, P. Andrew Futreal, Stian Knappskog, Tari King, Gilles Thomas, Alain Viari, Anita Langerød, Anne-Lise Børresen-Dale, Ewan Birney, Hendrik G. Stunnenberg, Mike Stratton, John A. Foekens, John W. M. Martens
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures
Externí odkaz:
https://doaj.org/article/0b80834b0f74411a8fac98a9ae2db59b
Autor:
Adam Shlien, Keiran Raine, Fabio Fuligni, Roland Arnold, Serena Nik-Zainal, Serge Dronov, Lira Mamanova, Andrej Rosic, Young Seok Ju, Susanna L. Cooke, Manasa Ramakrishna, Elli Papaemmanuil, Helen R. Davies, Patrick S. Tarpey, Peter Van Loo, David C. Wedge, David R. Jones, Sancha Martin, John Marshall, Elizabeth Anderson, Claire Hardy, Violetta Barbashina, Samuel A.J.R. Aparicio, Torill Sauer, Øystein Garred, Anne Vincent-Salomon, Odette Mariani, Sandrine Boyault, Aquila Fatima, Anita Langerød, Åke Borg, Gilles Thomas, Andrea L. Richardson, Anne-Lise Børresen-Dale, Kornelia Polyak, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 2032-2046 (2016)
Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct trans
Externí odkaz:
https://doaj.org/article/4492535398b04897a7bfaecb4a9c01d9
Autor:
Anthony Ferrari, Anne Vincent-Salomon, Xavier Pivot, Anne-Sophie Sertier, Emilie Thomas, Laurie Tonon, Sandrine Boyault, Eskeatnaf Mulugeta, Isabelle Treilleux, Gaëtan MacGrogan, Laurent Arnould, Janice Kielbassa, Vincent Le Texier, Hélène Blanché, Jean-François Deleuze, Jocelyne Jacquemier, Marie-Christine Mathieu, Frédérique Penault-Llorca, Frédéric Bibeau, Odette Mariani, Cécile Mannina, Jean-Yves Pierga, Olivier Trédan, Thomas Bachelot, Hervé Bonnefoi, Gilles Romieu, Pierre Fumoleau, Suzette Delaloge, Maria Rios, Jean-Marc Ferrero, Carole Tarpin, Catherine Bouteille, Fabien Calvo, Ivo Glynne Gut, Marta Gut, Sancha Martin, Serena Nik-Zainal, Michael R. Stratton, Iris Pauporté, Pierre Saintigny, Daniel Birnbaum, Alain Viari, Gilles Thomas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Breast cancer is separated into multiple subtypes based on the expression of HER2 and hormone receptors. Here, the authors report the whole genome sequence of 64 HER2 positive tumours and show that these can be further separated into four groups with
Externí odkaz:
https://doaj.org/article/ab0d2ca4b11b4f8888dd3d70ad443efe