Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sanath K. Meegalla"'
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7c495ed76df00defda047352171a57
https://doi.org/10.1158/1535-7163.c.6531858.v1
https://doi.org/10.1158/1535-7163.c.6531858.v1
Autor:
Christopher J. Molloy, Bruce E. Tomczuk, Danielle Lawrence, Christian Baumann, Heidi Ott, Shelley K. Ballentine, Jinsheng Chen, Mark J. Wall, Kenneth J. Wilson, Sanath K. Meegalla, Lisa Boczon, Edward J. Yurkow, Yanmin Chen, Carl Crysler, Lee Zeng, Carol F. Franks, Robert R. Donatelli, Margery A. Chaikin, Judith F. Baker, Zhao Zhou, Robert W. Tuman, Carl R. Illig, Dana L. Johnson, Carl L. Manthey
Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb53737462ca7c21b088c7e98afca976
https://doi.org/10.1158/1535-7163.22485255.v1
https://doi.org/10.1158/1535-7163.22485255.v1
Autor:
Eric Arnoult, Meghan Hall, Monicah A. Otieno, Hui Huang, Tonya Martin, Jose Silva, Joe Gunnet, Jianying Liu, Yuanping Wang, Shuyuan Zhao, Sanath K. Meegalla, June Xu, Alessandro Pocai, Mark R. Player, Brian Rady, S. Paul Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:720-726
Compound 12 is a GPR40 agonist that realizes the full magnitude of efficacy possible via GPR40 receptor agonism. In vitro and in vivo studies demonstrated superior glucose lowering by 12 compared to fasiglifam (TAK-875), in a glucose dependent manner
Autor:
Sanath K. Meegalla, Jose Silva, Thomas Wilde, Michael P. Winters, Jianying Liu, Fran Xu, Shuyuan Zhao, Brian Rady, Jenson Qi, Alessandro Pocai, Paul S. Lee, Tonya Martin, Mark R. Player, James Littrell, Monicah A. Otieno, Wing W. Lam, James C. Lanter, Heng-Keang Lim, Hui Huang
[Image: see text] GPR40 is a G-protein-coupled receptor which mediates fatty acid-induced glucose-stimulated insulin secretion from pancreatic beta cells and incretion release from enteroendocrine cells of the small intestine. GPR40 full agonists exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd9c88f3c2b104a8517817db45fd252
https://europepmc.org/articles/PMC6331191/
https://europepmc.org/articles/PMC6331191/
Autor:
Raymond J. Patch, Tianbao Lu, Hui Huang, Brian Rady, Alan Gibbs, Thomas Kirchner, Yu-Kai Lee, Carl R. Illig, Parks Daniel J, Margery A. Connelly, Sanath K. Meegalla, Mark R. Player, Wing S. Cheung, Chen Jinsheng, John G. Geisler, Hossein B. Askari, Kenneth J. Wilson, Sharmila Patel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4216-4222
Design and optimization of a novel series of imidazo[1,2-b]pyridazine PDE10a inhibitors are described. Compound 31 displays excellent pharmacokinetic properties and was also evaluated as an insulin secretagogue in vitro and in vivo.
Autor:
Tonya Martin, Fuyong Du, Jenson Qi, Alessandro Pocai, Norquay Lisa, Michael P. Winters, Sanath K. Meegalla, Andrea R. Nawrocki, Mark R. Player, Jianying Liu, Seunghun Paul Lee, Hui Huang, Brian Rady
Publikováno v:
Diabetes. 67
The free fatty acid receptor 1 (FFAR1) mediates fatty acid-induced insulin secretion from pancreatic β-cells. Numerous ligands have been investigated for their antidiabetic actions. The most advanced, fasiglifam (TAK-875), is a site 1 binding agonis
Autor:
Monicah A. Otieno, Jose Silva, Eric Arnoult, Michael P. Winters, Hui Huang, Tonya Martin, Mark R. Player, Sanath K. Meegalla, Meghan Towers, Heng-Keang Lim, Jianying Liu, S. Paul Lee, Shuyuan Zhao, Alessandro Pocai, Fran Xu, Brian Rady
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
GPR40 partial agonism is a promising new mechanism for the treatment of type 2 diabetes mellitus with clinical proof of concept. Most of the GPR40 agonists in the literature have a carboxylic acid functional group, which may pose a risk for idiosyncr
Autor:
Shelley K. Ballentine, Mark R. Player, Mary Lou Lubin, Raul R. Calvo, Craig R. Schneider, William H. Parsons, Raymond W. Colburn, Parks Daniel J, Sanath K. Meegalla, Christopher M. Flores
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1903-1907
Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy
Autor:
Christopher J. Molloy, Shelley K. Ballentine, Edward J. Yurkow, Carsten Schubert, Carl Crysler, Renee L. DesJarlais, Yanmin Chen, Sanath K. Meegalla, Carl L. Manthey, Mark J. Wall, Bruce E. Tomczuk, Carl R. Illig, Zhao Zhou, Jinsheng Chen, Kenneth J. Wilson, Mark R. Player, Robert R. Donatelli, Margery A. Chaikin
Publikováno v:
Journal of Medicinal Chemistry. 54:7860-7883
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. Early stage absorption,
Autor:
Danielle Lawrence, Yanmin Chen, Mark J. Wall, Carl L. Manthey, Christopher J. Molloy, Edward J. Yurkow, Kenneth J. Wilson, Sanath K. Meegalla, Dana L. Johnson, Carol F. Franks, Bruce E. Tomczuk, Lee Zeng, Shelley K. Ballentine, Baumann Christian Andrew, Zhao Zhou, Judith Baker, Robert R. Donatelli, Lisa Boczon, Carl Crysler, Carl R. Illig, Heidi Ott, Jinsheng Chen, Tuman Robert W, Margery A. Chaikin
Publikováno v:
Molecular Cancer Therapeutics. 8:3151-3161
There is increasing evidence that tumor-associated macrophages promote the malignancy of some cancers. Colony-stimulating factor-1 (CSF-1) is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. Her