Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Sanat K Mandal"'
Autor:
Soumya Panigrahi, Jörg Stetefeld, Jaganmohan R Jangamreddy, Soma Mandal, Sanat K Mandal, Marek Los
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28395 (2012)
In this study we have calculated a 3D structure of apoptin and through modeling and docking approaches, we show its interaction with Bcr-Abl oncoprotein and its downstream signaling components, following which we confirm some of the newly-found inter
Externí odkaz:
https://doaj.org/article/656e78c4119b43bda0cc0181d4f7153a
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:4133-4139
We report the binding of testo and testo–Pt(II) complexes (testosterone derivatives) with tRNA in aqueous solution at physiological pH. Thermodynamic parameter ΔH0 −8 to −3 (kJ mol−1), ΔS0 ...
Publikováno v:
Chemico-Biological Interactions. 296:179-184
The development of new targeted anticancer agents able to efficiently and specifically destroy cancer cells with minimal toxic side effects is nowadays a subject of intensive research endeavors. We report the conjugation of testo and testo-Pt(II) (tw
Publikováno v:
Postgraduate medicine. 58(2)
Echocardiography occupies a unique place as an investigative tool in cardiology. This introduction to the technique reviews the basic principles and outlines the diagnosis of common cardiac lesions. Being entirely noninvasive, echocardiography can be
Autor:
Klaus Schulze-Osthoff, Joerg Stetefeld, Frank Essmann, Marek Los, Iran Rashedi, Sanat K. Mandal, Soumya Panigrahi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1793(8):1335-1342
Apoptin, a small protein from chicken anemia virus, has attracted great attention, because it specifically kills tumor cells while leaving normal cells unharmed. The subcellular localization of apoptin appears to be crucial for this tumor-selective a
Autor:
Arthur L. Williams, Iqbal Mohammad, Soma Mandal, Eric Asselin, Vernon J. Richardson, Atul Gupta, Gervais Bérubé, Sanat K. Mandal, Saroj K. Pramanik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4955-4960
Breast cancer, a leading cause of mortality in women, warrants the development and biological evaluation of new anticancer agents. A novel series of thiopyridine triazine derivatives was synthesized and investigated in the human breast cancer cell li
Autor:
Jon G. Church, Soma Mandal, Vernon J. Richardson, Sanat K. Mandal, Saroj K. Pramanik, John N. Bridson, Gervais Bérubé, Tram N. Q. Pham, Eric Asselin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2139-2145
A novel class of platinum(II) complexes of pyridine sulfide derivatives of triazine was synthesized, characterized, and investigated using the human breast cancer cell line, MDA-MB-468. S-30 was one of the most potent derivatives of its class (IC(50)
Autor:
Ethan Emberley, J.N. Myers, Spencer B. Gibson, Linda Curtis, Leigh C. Murphy, Sanat K. Mandal, Yulian Niu, Sandra Troup, Peter H. Watson
Publikováno v:
Cancer Research. 65:5696-5702
S100A7 is among the most highly expressed genes in preinvasive breast cancer, is a marker of poor survival when expressed in invasive disease, and promotes breast tumor progression in experimental models. To explore the mechanism of action, we examin
Synthesis of 17β-estradiol platinum(II) complexes: biological evaluation on breast cancer cell lines
Autor:
Sanat K. Mandal, Caroline Descôteaux, Isabelle Mathieu, Josée Provencher-Mandeville, Valérie Perron, Gervais Bérubé, Eric Asselin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3927-3931
The synthesis of a novel series of 17β-estradiol-linked platinum(II) complexes is described. The new molecules are linked with an alkyl chain at position 16α of the steroid nucleus and bear a 16β-hydroxymethyl side chain. They are made from estron
Publikováno v:
Journal of Electroanalytical Chemistry. 389:115-121
A dinuclear Co(II) complex with pyrrole substituents has been found to undergo reductive polymerization but does not polymerize under oxidizing conditions. The polymerization occurs on a variety of substrate electrode materials. It involves cleavage